Bullous Disorders of Childhood

Paller, Amy S.; Mancini, Anthony J.

doi:10.1016/b978-1-4377-0412-9.00013-7

Cited by 11 publications

(7 citation statements)

References 179 publications

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“…These rashes often occur in stages and can vary in severity, beginning with the appearance of erythema, followed by edema, then the formation of superficial erosions, ulcerated nodules that can manifest as faint pinks or very intense reds in color, slight dryness or severe desquamation, or a single papule or confluent papules (see Figures 5 and 6). 5…”

Section: Considering Other Conditions That Present Rashmentioning

confidence: 99%

Setting the Record Straight on Diaper Rash and Disposable Diapers

Clark-Greuel

Helmes²,

Lawrence

et al. 2014

Clin Pediatr (Phila)

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Skin in the diapered area is continuously threatened by exposure to changes in pH levels, overhydration, mechanical friction, and fecal enzymes, making diaper rash a common occurrence among babies. Up to one third of infants may exhibit clinical symptoms of diaper rash at any time, and more than half of babies between the ages of 4 and 15 months develop diaper rash at least once in a 2-month period. Despite misperceptions that disposable diapers are related to an increase in diaper rash, the incidence of diaper dermatitis is on the decline, largely due to significant improvements in disposable diaper construction and materials. Modern-day disposable diapers are specifically designed to limit exposure to irritants in the diaper area, reduce overhydration, inhibit skin barrier compromise, and help maintain normal skin pH levels and have been thoroughly evaluated for safety and skin compatibility.

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Section: Considering Other Conditions That Present Rashmentioning

confidence: 99%

Setting the Record Straight on Diaper Rash and Disposable Diapers

Clark-Greuel

Helmes²,

Lawrence

et al. 2014

Clin Pediatr (Phila)

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“…Though PCLs are far more prevalent than SCLs in the pediatric population, SCL will be the focus of this section as it represents a cutaneous manifestation of systemic malignancy. Ruling out systemic involvement is required for PCL diagnosis, and PCL can transform into systemic lymphoma, thus regular follow-up and screening is indicated [1]. The most common SCLs in children are Non-Hodgkin lymphomas (NHL) including extranodal marginal zone lymphoma (EMZL), diffuse large B-cell lymphoma (DLBCL), and anaplastic large cell lymphoma (ALCL) [12,13 && ,14].…”

Section: Cutaneous Lymphomamentioning

confidence: 99%

“…The most common SCLs in children are Non-Hodgkin lymphomas (NHL) including extranodal marginal zone lymphoma (EMZL), diffuse large B-cell lymphoma (DLBCL), and anaplastic large cell lymphoma (ALCL) [12,13 && ,14]. Presentation of SCL is most commonly a 5-10 cm firm, erythematous, solitary nodule on the head or neck > the abdomen [1]. Other presentations include pink to red-brown violaceous papules and nodules in similar distribution.…”

Section: Cutaneous Lymphomamentioning

confidence: 99%

“…Treatment is based on type and stage of lymphoma. An absence of consensus on pediatric treatment protocol for many of these rare lymphomas persists, but chemotherapy and SCT are mainstays [1,12].…”

Section: Cutaneous Lymphomamentioning

confidence: 99%

“…A notable childhood paraneoplastic syndrome is paraneoplastic pemphigus (PNP). Others include juvenile dermatomyositis, Sweet syndrome, and pyoderma gangrenosum [1,45]. In children, PNP is most frequently seen in the setting of Castleman's disease, a rare, benign lymphoproliferative disorder, though it is almost always associated with myeloproliferative and lymphoproliferative disorders in adults [45,46,47 & ,48].…”

Section: Paraneoplastic Syndromesmentioning

confidence: 99%

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Pearls and updates: cutaneous signs of systemic malignancy

Paquette

Cotter

Huang

2022

Current Opinion in Pediatrics

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Purpose of reviewChildren with systemic malignancies can present with concomitant dermatological manifestations. Cutaneous findings can occur before, during or after diagnosis. Recognizing these features can aid in diagnosis, inform prognosis, and help determine appropriate treatment. Following a review of the literature published over the past two years, we provide an update on cutaneous signs of pediatric systemic malignancies, concentrating on; leukemia cutis, lymphoma cutis, neuroblastoma, sarcomas, Langerhans cell histiocytosis and paraneoplastic syndromes. Recent findingsAuthors highlight the persistently heterogeneous features of cutaneous manifestations of systemic malignancy. Findings are often nonspecific, and a definitive diagnosis requires skin biopsy with immunophenotyping. Several studies describe dermoscopy features, demonstrating this as a useful tool in clinical evaluation. Genetic mutations underlying the pathogenesis of disease continue to be elucidated. Further, advances in medical treatment led to improved prognosis in many systemic malignancies, with early and aggressive treatment heralding better outcomes. SummaryComprehensive cutaneous evaluation alongside thorough clinical history and review of systems remains of paramount importance as dermatological manifestations of systemic malignancy are notoriously variable with a shared feature of often appearing benign but persisting despite usual treatment. Urgent referral to dermatology is recommended when suspicion for any cutaneous presentation of malignancy arises.

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