Bullous fixed drug eruption due to paracetamol with an unusual immunofluorescence pattern

Hern,; Harman, Mark; Clément,; Black,

doi:10.1046/j.1365-2133.1998.2576o.x

Cited by 16 publications

(9 citation statements)

References 8 publications

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“…Atypical histopathological reaction patterns such as leukocytoclastic vasculitis [9], neutrophilic reaction [14, 15] and a predominantly dermal reaction without pigment incontinence in what is termed non‐pigmented FDE have been reported [5]. In addition, cases with positive immunofluorescence have been described [16].…”

Section: General Informationmentioning

confidence: 99%

Fixed drug eruption:state of the art

Özkaya

2007

J Deutsche Derma Gesell

101

110

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Fixed drug eruption (FDE) is a common type of cutaneous adverse drug reaction. There may be a genetic background as significant associations have been identified between HLA types and specific FDE.Systemic provocation is still the gold standard for establishing the offending agent in FDE,but topical provocation testing offers a promising alternative approach. A standardized method does not exist, and the approach must likely be varied for different agents. The mystery of site preference in FDE is still unresolved. Possible explanations include properties of the drug, trauma and viscerocutaneous reflex patterns.

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Section: General Informationmentioning

confidence: 99%

Fixed drug eruption:state of the art

Özkaya

2007

J Deutsche Derma Gesell

101

110

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“…Generalized bullous FDE following influenza vaccination has also been reported 51 . Infrequently, bullous leukocytoclastic vasculitis and extensive FDE mimicking toxic epidermal necrolysis 23 or Stevens–Johnson syndrome 22 have been recorded; however, a milder form of bullous FDE is more frequent in which the lesion number may vary from one to 10 54–58 . Commonly incriminated drugs for bullous FDE are rifampicin, 53 metronidazole, 58 paracetamol, 57 paclitaxel, 56 vinburnine, 55 erythromycin, 54 and ibuprofen 52 .…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Infrequently, bullous leukocytoclastic vasculitis and extensive FDE mimicking toxic epidermal necrolysis 23 or Stevens–Johnson syndrome 22 have been recorded; however, a milder form of bullous FDE is more frequent in which the lesion number may vary from one to 10 54–58 . Commonly incriminated drugs for bullous FDE are rifampicin, 53 metronidazole, 58 paracetamol, 57 paclitaxel, 56 vinburnine, 55 erythromycin, 54 and ibuprofen 52 . The involvement of the oral mucous membrane 59,60 /lips, glans penis/genitals, 45,61–63 perineal area, 64,65 and tongue 66 is fairly common.…”

Section: Clinical Featuresmentioning

confidence: 99%

Fixed drug eruption (FDE): changing scenario of incriminating drugs

Sehgal¹,

Srivastava²

2006

Int J Dermatology

106

115

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“…[23] Only few cases of acetaminophen-induced generalized-bullous fixed drug eruption have been reported in literature. [45] We report a case of generalized-bullous-fixed drug eruption induced by acetaminophen and presenting initially like cellulitis.…”

Section: Introductionmentioning

confidence: 99%

Acetaminophen-induced cellulitis-like fixed drug eruption

et al. 2011

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Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash; there was a spectacular extension of the lesion with occurrence of flaccid vesicles and blisters in the affected sites. The diagnosis of generalized-bullous-fixed drug eruption induced by acetaminophen was considered especially with a reported history of a previous milder reaction occurring in the same site. Acetaminophen was withdrawn and the rash improved significantly. According to the Naranjo probability scale, the eruption experienced by the patient was probably due to acetaminophen. Clinicians should be aware of the ability of acetaminophen to induce fixed drug eruption that may clinically take several aspects and may be misdiagnosed.

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Bullous fixed drug eruption due to paracetamol with an unusual immunofluorescence pattern

Cited by 16 publications

References 8 publications

Fixed drug eruption:state of the art

Fixed drug eruption:state of the art

Fixed drug eruption (FDE): changing scenario of incriminating drugs

Acetaminophen-induced cellulitis-like fixed drug eruption

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