Bullous Pemphigoid and Metastatic Skin Cancer

Ikai, Kouichi; Imamura, Sadao; Ogino, A; Danno, Kiichiro; Hayakawa, Minoru

doi:10.1159/000250897

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…As far as therapy and the course of PAM are concerned, pharmacological control of the bullous disease, regardless of the tumor progression, was achieved in 13 cases. The most used treatment was systemic corticosteroid therapy, combined with immunosuppressive drugs in 11 patients . In two cases, the skin disease was controlled only by topical therapy …”

Section: Discussionmentioning

confidence: 99%

Malignancies in bullous pemphigoid: A controversial association

Balestri

Magnano

Plaça

et al. 2015

The Journal of Dermatology

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Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disorder that has been reported to be associated with malignancies. Some authors described several cases of pemphigoid associated with malignancies (PAM); however, the evidence of this correlation still remains controversial. Several theories have been postulated to explain the relationship between malignant neoplasms and BP; the main theory suggests that antibodies directed against tumor-specific antigens of malignant cells may cross-react with antigens (like BP antigens) in the basement membrane zone leading to the formation of blisters. We performed an extensive review of the English published work focusing on the epidemiology, the pathogenetic theories and the clinical and histological aspects of the disease. We identified 40 cases of PAM: of these, seven cases were associated with hematological malignancies and 33 with solid tumors. Physicians should be aware of the existence of PAM and we suggest an oncological screening in early-onset pemphigoid, in patients with a former oncological history, in those with signs and symptoms that could be related to a neoplasm and in BP refractory to common immunosuppressive therapy.

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Section: Discussionmentioning

confidence: 99%

Malignancies in bullous pemphigoid: A controversial association

Balestri

Magnano

Plaça

et al. 2015

The Journal of Dermatology

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Pemphigoid and Cancer

Lindelöf

Islam²,

Eklund³

et al. 1990

Arch Dermatol

100

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To evaluate the significance of the association of malignant disease with bullous pemphigoid, we reviewed 497 consecutive cases with positive immunofluorescence tests for circulating antibodies to basement membrane. We searched the Swedish Cancer Registry, Stockholm, Sweden, for records reporting malignancies in the study population (1958 to 1985), and the expected number of malignancies was calculated on the basis of age- and sex-standardized incidence data. In 61 patients, a total of 69 malignancies were diagnosed. The expected number of malignancies was 82.6. In 25 patients, a total of 27 malignancies appeared during the same year as the onset of pemphigoid, or later. The expected number was 35.8. The median titer of circulating antibodies in the 497 patients, in the 61 patients with malignancy, and in the 25 patients with malignancy preceded by the pemphigoid, were not significantly different. We conclude that pemphigoid is not statistically associated with malignancy, and that the former hypothesis of such an association was based on age only.

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