Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample

Vernal, Sebastián; Oliveira, Éderson V.L.; Filho, Roberto Bueno; Julio, Tamiris Amanda; Donadi, Eduardo Antônio; Turatti, Aline; Ishii, Norito; Hashimoto, Takashi; Roselino, Ana Maria

doi:10.1016/j.abd.2021.10.003

Anais Brasileiros de Dermatologia

2022

DOI: 10.1016/j.abd.2021.10.003

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Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample

Sebastián Vernal¹,

Éderson V.L. Oliveira²,

Roberto Bueno Filho³

et al.

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Cited by 2 publications

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“…Finally, our patient showed milium formation in skin previously affected by PV. Therefore, we also performed various IIF, ELISA, and immunoblotting analyses, which excluded the diagnoses of epidermolysis bullosa acquisita and bullous pemphigoid, the diseases commonly developing milia 4 .…”

mentioning

confidence: 99%

Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia formation

Vernal¹,

Bueno²,

Hashimoto³

et al. 2023

Anais Brasileiros de Dermatologia

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mentioning

confidence: 99%

Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia formation

Vernal¹,

Bueno²,

Hashimoto³

et al. 2023

Anais Brasileiros de Dermatologia

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Milia En Plaque After Bullous Pemphigoid: An Unusual Sequela

Chen,

Elhawi,

Selby

et al. 2024

Cureus

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We present the case of a 36-year-old paraplegic woman with a history of spinal cord injury who developed a generalized blistering rash, later diagnosed as bullous pemphigoid (BP). During her hospitalization, she was treated with prednisone and rituximab infusions, transitioning to maintenance therapy with topical steroids, doxycycline, and nicotinamide. A year later, she presented with concerns about a BP flare on her feet. Examination revealed 1-2 mm white, dome-shaped papules coalescing into erythematous plaques on the plantar surfaces, leading to a diagnosis of milia en plaque (MEP). Treatment with tretinoin 0.05% cream resulted in near-complete resolution within six months. MEP is a rare but benign condition characterized by keratinous cysts on erythematous plaques, often linked to immunobullous disorders such as epidermolysis bullosa acquisita or mucous membrane pemphigoid, and only rarely associated with BP. Distinguishing MEP from active BP is critical, as the latter requires immunosuppressive therapy, while MEP can be managed conservatively. This case underscores MEP as a sequela of BP, highlighting the importance of accurate diagnosis and appropriate management.

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Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample

Cited by 2 publications

References 20 publications

Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia formation

Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia formation

Milia En Plaque After Bullous Pemphigoid: An Unusual Sequela

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