Bullous pemphigoid positive for anti-BP180 and anti-laminin 5 antibodies in a patient with graft-vs-host disease

Mucous Membrane Pemphigoid with Antibodies to the β3Subunit of Laminin 332 in a Patient with Acute Myeloblastic Leukemia and Graft-versus-Host Disease

“…The present case did not have any clinical findings indicating chronic GVHD at the onset of MMP. However, it might be possible that undiscovered slight attacks of GVHD triggered these cases of MMP, since more than 10 cases of autoimmune blistering diseases, mostly BP, after allogeneic BMT have been reported to date [18,19] . Indeed, various autoimmune diseases, including vitiligo, have been shown to develop in patients with GVHD [20,21] , although the mechanism is unknown.…”

IgG anti-laminin-332 autoantibodies are present in a subset of patients with mucous membrane, but not bullous, pemphigoid

“…While bullous disease patients with autoantibodies against multiple autoantigens (including L-332) in epidermal BM have been described, such patients are relatively rare [25][26][27][28][29][30] . In contrast, a recent study found that 29 of 72 patients with BP (40%) had circulating IgG reactive with L-332 by ELISA 9 .…”

Basement membrane antibodies in sera of haematopoietic cell recipients are associated with graft‐versus‐host disease

“…Functional alterations of basal keratinocytes during GvHD are indeed reflected by reduced expression of the BP antigen in contrast to the pemphigus antigens 18 . In the past, several cases of bullous immune‐mediated dermatoses, mostly BP, in GvHD patients have been reported 7 . In addition, a case of BP and a case of linear IgA dermatosis in HCT patients without GvHD were published 19,20 …”