Bullous Transient Acantholytic Dermatosis

Neutrophil-rich Variant of Persistent Bullous Grover’s Disease

“…The persistent nature of the disease in the present case corresponds to the variant "persistent acantholytic dermatosis", named by Simon et al 1The present case was unique in having prominent bullous lesions surrounded by minimal erythema and neutrophil-rich infiltration. Bullous lesions have been reported as a rare clinical variant of Grover's disease, although their clinical significance remains unknown (2,3). Recently, Fernandez-Figueras et al conducted a histopathological analysis of cases of Grover's disease and demonstrated an abundant neutrophilic infiltration in 5% of examined cases (4).…”

Grover's disease in a patient with pemphigus vulgaris

“…Moreover, histologic diagnosis of GD may be challenging because characteristic histologic changes are not infrequently focal and subtle, and, in many cases, several biopsies have been required for making proper diagnosis . Three cases of bullous variant of GD have been described, which were not only histologically but also clinically similar to pemphigus foliaceus . It is difficult to make a correct diagnosis in a case of GD showing clinical and/or histologic appearances similar to pemphigus.…”

Effective Treatment of Persistent Grover's Disease with Trichloroacetic Acid Peeling

“…Many nonsurgical treatments for TAD have been attempted (Table 3), but because TAD is often self‐limiting, it is difficult to accurately gauge the efficacy of any one treatment. Topical therapies, including vitamin D analogs, 20,21 retinoids, 16,22,23 lactic acid, 16 urea, 24 and corticosteroids, have been tried 25 . Photochemotherapy as well as narrowband ultraviolet B have demonstrated success; however, ironically, Grover's disease may also be exacerbated by PUVA 26,27 .…”

“…Photochemotherapy as well as narrowband ultraviolet B have demonstrated success; however, ironically, Grover's disease may also be exacerbated by PUVA 26,27 . Debilitating cases may require oral therapy, such as with systemic steroids 25,28 . The treatment of other dyskeratotic conditions with vitamin A has led to its use in Grover's disease, 8 and in four patients, treatment with isotretinoin resulted in remission in three of the four patients 29 .…”