Büllöz pemfigoidli hastalarda 3 yıllık gözlem: 29 olgu

Ekiz, Özlem; Şen, Bilge Bülbül; Rifaioğlu, Emine Nur; Şen, Tuğba; Atık, Esin; Doğramacı, Asena Çiğdem

doi:10.4274/turkderm.80664

Cited by 4 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, Bushkell and Jordon reported a 5-43% rate of eosinophilia in the peripheral blood in BP patients. 16,17 In our study, peripheral blood eosinophilia was found in 38% of the patients.…”

Section: Discussionsupporting

confidence: 51%

“…In another study, 62% of BP patients were treated with topical corticosteroid and tetracyclines and nicotinamide combination. 16 Tetracyclines are usually preferred in patients with accompanying comorbidities, such as DM or HT, and in children due to their better safety profile. There is also evidence in favor of using immunosuppressants, such as azathioprine and MTX.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Features, Associated Systemic Diseases, Mortality Rates, and Treatment Protocols in a Group of Turkish Patients with Bullous Pemphigoid

Serdar¹,

Karabay²,

Yaşar³

et al. 2018

Turkiye Klinikleri J Dermatol

View full text Add to dashboard Cite

The aim of the study was to investigate the clinical features, associated systemic diseases, treatment protocols, recurrence rates, and mortality rates in bullous pemphigoid (BP) patients. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The demographic and clinical characteristics of 47 patients with BP were evaluated. 47 age and gender-matched subjects without autoimmune bullous disease were included as the control group. The comorbidities accompanying to BP patients and the diseases in the control group were compared. R Re es su ul lt ts s: : The mean age of the patients was 77.9±10.57 (36-96) years old, and the average disease duration was 39.30±29.54 months. The BP patients were compared with the control group in terms of systemic diseases using a chi-squared test with a 95% confidence interval. No significant differences were found between the BP patients and the control group with regard to the associated systemic diseases, including hypertension (HT), diabetes mellitus (DM), neurological disease, heart disease, malignancy, and other diseases. Systemic corticosteroids (methylprednisolone) were administered to 34 (72.3%) of the patients, while 12 (25%) patients were given methylprednisolone alone. Azathioprine and methotrexate were added to the treatments of 5 (10.6%) and 3 (6.4%) of the cases, respectively. Eight (17%) patients showed recurrences, and the mortality rate was 23.4%. C Co on nc cl lu us si io on n: : Although the results of our study showed that a significant proportion of the BP patients had an accompanying systemic disease, most frequently hypertension and diabetes mellitus, there was not a statistically significant difference in terms of comorbidities between BP patients and controls. Systemic corticosteroids were the most commonly used treatments. Overall, our data from this 7-year period will contribute to the understanding of the characteristics of the BP patients in Turkey. K Ke ey yw wo or rd ds s: : Bullous pemphigoid; comorbidity; mortality; recurrence; therapy Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmanın amacı büllöz pemfigoid (BP) hastalarında klinik özellikleri, ilişkili sistemik hastalıkları, tedavi protokollerini, nüks oranlarını ve mortalite oranlarını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 47 BP hastasının demografik ve klinik özellikleri değerlendirildi. Yaş ve cinsiyet açısından hasta grubuyla uyumlu olan otoimmün büllü hastalığı olmayan 47 kişi kontrol grubunu oluşturdu. BP hastalarına eşlik eden komorbiditeler ve kontrol grubunda bulunan hastalıklar karşılaştırıldı. B Bu ul lg gu ul la ar r: : Hastaların ortalama yaşı 77.9±10.57 (36-96) yıl ve ortalama hastalık süresi 39.30±29.54 ay idi. BP hastaları kontrol grubuyla sistemik hastalık bulunması açısından ki-kare test kullanılarak %95 güven aralığıyla karşılaştırıldı. BP hastaları ile kontrol grubu arasında hipertansiyon (HT), diabetes mellitus (DM), nörolojik hastalıklar, kalp hastalıkları, malignite gibi eşlik eden sistemik hastalıklar açısından belirgin fark bulunmadı. 34 hastaya (%72...

show abstract

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Clinical Features, Associated Systemic Diseases, Mortality Rates, and Treatment Protocols in a Group of Turkish Patients with Bullous Pemphigoid

Serdar¹,

Karabay²,

Yaşar³

et al. 2018

Turkiye Klinikleri J Dermatol

View full text Add to dashboard Cite

show abstract

“…İngiltere'de yapılan 869 olguluk retrospektif çalışmada hastalığın başlangıç yaşı median 80 olarak bildirilmiştir 13 . Ülkemizde yapılan diğer çalışmalarda (Tablo 2) [14][15][16][17] olduğu gibi olgularımızın yaş ortalaması 60 üzerindeydi. Olgularımızın tanı anındaki yaşı ortalama 69,54 olarak saptanırken en genç olgu 18 yaşında idi.…”

Section: Discussionunclassified

“…Olgularımızın tanı anındaki yaşı ortalama 69,54 olarak saptanırken en genç olgu 18 yaşında idi. Hastalık her iki cinsiyeti de etkilemekle birlikte kadınlarda 16 bildirilerine benzer olarak çalışmamızda BP erkeklerde (E/K oranı: 1,09) hafif fazla saptanmıştır. Etiyopatogenezi tam olarak bilinmeyen hastalıkta çeşitli çevresel faktörlerin anti-epidermal bazal membran antikor oluşumunu tetiklediği düşünülmektedir 19 .…”

Section: Discussionunclassified

Retrospective analysis of the forty-six patients with bullous pemphigoid followed-up in our clinic

Yazıcı¹,

Başkan²,

Tunali³

et al. 2016

TURKDERM

View full text Add to dashboard Cite

Background and Design: Bullous pemphigoid (BP) is an autoimmune disease characterised by widespread itchy plaques and subepithelial blisterings and usually affects the elderly population. Due to the chronic nature of the disease, to prevent the side effects of chronic steroid treatment, adjuvant immunosuppressive (mycophenolate mofetil, azathioprine, methotrexate) and anti-inflammatory (tetracycline, nicotinamide, dapsone) agents may be used. In this study, we retrospectively evaluated the clinical and demographic characteristics and applied treatments of 46 patients with the diagnosis of BP and compared with literature data. Materials and Methods: We retrospectively evaluated the records of 46 patients who received clinical and histopathological diagnosis of BP and followed up in our clinic between 2006 and 2013. Results: Of the 46 patients, 22 were female and 24 male. The mean age of onset was 69.54 years (range: 18-105). The duration of the lesion ranged from 1 week to 10 months with a median duration of 8 weeks. The most frequent comorbid chronic disease was hypertension detected in 28 (60.8%) patients. Only four patients had a history of malignancy before the onset of the disease. Nineteen patients (42%) used more than 5 agents for comorbid diseases. Thirty-two patients (69.5%) used systemic corticosteroids alone and ten (22%) patients needed additional adjuvant therapies. Conclusion: BP is a major cause of morbidity in the elderly population receiving multiple drug treatment. To avoid the side effects of steroid therapy, especially in patients with severe disease, short-term use of additional immunosuppressive agents appears to be safe and effective.

show abstract

“…Ekiz ve ark. 'nın, Hatay ve çevresinde 29 olgu ile yaptıkları çalışmada BP insidansı 9,6 olarak bulunmuştur 9 . BP tipik olarak yaşlılarda görülmektedir ancak gençlerde görülen olgularda yaşlı hastalara göre daha şiddetli seyir gözlenir 10 .…”

Section: Discussionunclassified

Bullous pemphigoid in Erzurum: A 10 year retrospective study

Kızılyel¹,

Elmas²,

Bilen³

et al. 2015

TURKDERM

View full text Add to dashboard Cite

Background and Design: Bullous pemphigoid is a rare autoimmune blistering disease. The aim of this study was to investigate the epidemiological characteristics and clinical, laboratory, and radiological features of patients with bullous pemphigoid in Erzurum and to evaluate the association of bullous pemphigoid with comorbid diseases. Methods and Methods: Medical records of 38 patients, who were diagnosed with bullous pemphigoid after biopsy and hospitalized in our clinic between 2003 and 2013, were retrospectively studied. Results: Fifteen (39.5%) of the 38 patients were male, and 23 (60.5%) were female. The mean age at the time of diagnosis was 62.4±21 years. Analyses of the results of direct immunofluorescence showed that the most common finding was the presence of IgG and C3 (42.1%). The average time since the first presentation until diagnosis was 72.7±104.3 days. The mean initial dose of corticosteroid was 54.7±26.01 mg/ day. The mean length of hospitalization for bullous pemphigoid was 22.6±23.5 days. We did not detect any malignancy or comorbid diseases associated with bullous pemphigoid. However, eosinophilia was detected. Conclusions: Routine laboratory and radiological investigations are not necessary to detect malignancy in patients with bullous pemphigoid. (Turkderm 2015; 49: 66-9)

show abstract

Büllöz pemfigoidli hastalarda 3 yıllık gözlem: 29 olgu

Cited by 4 publications

References 22 publications

Clinical Features, Associated Systemic Diseases, Mortality Rates, and Treatment Protocols in a Group of Turkish Patients with Bullous Pemphigoid

Clinical Features, Associated Systemic Diseases, Mortality Rates, and Treatment Protocols in a Group of Turkish Patients with Bullous Pemphigoid

Retrospective analysis of the forty-six patients with bullous pemphigoid followed-up in our clinic

Bullous pemphigoid in Erzurum: A 10 year retrospective study

Contact Info

Product

Resources

About