Bundling HIV and TB Care at a District-Level Center in Sierra Leone: A high-yield method for diagnosing co-infection with TB and antiretroviral treatment failure among people living with HIV

Oxner, Asa; Kongpakpaisarn, Kullatham; Hudey, S.; Myers, A. R.; Sesay, John; Thomas, John Bawel; Daboh, Fodei; Kabba, Alpha; Fillie, Admire; Kainessie, Aminata Tina; Abdulai, Tamba S.; Elliott, Eric L.

doi:10.1016/j.ijid.2019.03.018

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Nevertheless, current data on HIV-positive MDR-TB reveals increased mortality, as well as poor prognosis when compared to HIV-negative counterparts, which may be attributable to a lack of adequate and available ART (62). Where ART is available, the standardized protocol consists of two possible regimens: zidovudine 300 mg/lamivudine 150 mg/nevirapine 200 mg given twice daily or tenofovir disoproxil 300 mg/lamivudine 300 mg/efavirenz 600 mg given once daily (63). Tenofovir has been found to interact with aminoglycosides, as such avoidance in simultaneous prescription is recommended.…”

Section: Multidrug-resistant Tbm In Hiv-infected Casesmentioning

confidence: 99%

Tuberculosis meningitis coexisting with HIV Infection: a comprehensive review

Navasardyan,

Abdou,

Kades

et al. 2023

Front. Tuberc

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Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) in humans, Although Mtb is primarily considered a respiratory pathogen, its ability to spread to and affect the central nervous system (CNS) is of particular interest due to its clinical importance. Tuberculosis meningitis (TBM) is described as the manifestation of Mtb infection in the meninges, leading to inflammation and disease. Individuals with a weakened immune system, particularly those infected with human immunodeficiency virus (HIV), are more susceptible to both pulmonary and extrapulmonary Mtb infection. HIV infection leads to a gradual depletion of CD4 T-cells, severely impairing the host's immune response against pathogens and, thus, predisposes one to several opportunistic infections, including Mtb. Herein, we discuss the current knowledge, potential therapeutic agents, and mechanisms of action and describe various in vivo and in vitro models that may be used to study TBM coexisting with HIV infection.

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Section: Multidrug-resistant Tbm In Hiv-infected Casesmentioning

confidence: 99%

Tuberculosis meningitis coexisting with HIV Infection: a comprehensive review

Navasardyan,

Abdou,

Kades

et al. 2023

Front. Tuberc

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Antivirals

2019

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Diagnosis and treatment outcomes of adult tuberculosis in an urban setting with high HIV prevalence in Sierra Leone: A retrospective study

Lakoh

Jiba

Adekanmbi

et al. 2020

International Journal of Infectious Diseases

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To assess the diagnosis, treatment outcomes, and predictors of mortality in adult tuberculosis (TB) patients in an urban setting with a high HIV prevalence. Methods: A retrospective study was conducted of adult TB patients aged 15 years who were treated at Connaught Hospital in Freetown, Sierra Leone from January through December 2017. Multivariate logistic regression was used to identify predictors of mortality. Results: Of 1127 TB cases notified in 2017, 1105 (98%) were tested for HIV, yielding a TB/HIV co-infection rate of 32.0%. Only HIV-tested cases (n = 1105) were included in the final analysis. The majority were male (69.3%), aged 25-34 years (29.2%), and had pulmonary TB (96.3%). Treatment outcomes were as follows: 29.0% cured, 29.0% completed, 0.5% treatment failure, 24.2% lost to follow-up, 12.8% transferred/not evaluated, and 4.5% died. The majority of deaths (80.0%, 40/50) occurred within 2 months of TB treatment initiation. Age 65 years or older (adjusted odds ratio 3.48, 95% confidence interval 1.15-10.56; p = 0.027) and HIV-positive status (adjusted odds ratio 3.50, 95% confidence interval 1.72-7.12; p = 0.001) were independent predictors of mortality. Conclusions: Suboptimal TB treatment outcomes were observed in Sierra Leone in 2017. More local and international action is warranted to help achieve the 2035 global TB elimination targets.

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Bundling HIV and TB Care at a District-Level Center in Sierra Leone: A high-yield method for diagnosing co-infection with TB and antiretroviral treatment failure among people living with HIV

Cited by 3 publications

References 9 publications

Tuberculosis meningitis coexisting with HIV Infection: a comprehensive review

Tuberculosis meningitis coexisting with HIV Infection: a comprehensive review

Antivirals

Diagnosis and treatment outcomes of adult tuberculosis in an urban setting with high HIV prevalence in Sierra Leone: A retrospective study

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