Buprenorphine as an adjuvant in supraclavicular brachial plexus block.

Singam, Amol; Chaudhari, Ashok; Nagrale, Manda

doi:10.7439/ijbar.v3i7.511

Cited by 4 publications

(7 citation statements)

References 14 publications

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“…Singam et al . [ 17 ] reported the total duration of sensory block and motor block when 2 ml (0.3 mg) buprenorphine was added to the local anesthetic and then used for supraclavicular block as 647.83 ± 55.70 min and 306.33 ± 20.12 min, respectively, which is quite close to the findings of the present study.…”

Section: Discussionsupporting

confidence: 89%

Use of 0.5% bupivacaine with buprenorphine in minor oral surgical procedures

Nagpal¹,

Kaur²,

Kapila³

et al. 2017

Natl J Maxillofac Surg

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Background:Minor oral surgical procedures are the most commonly performed procedures by oral and maxillofacial surgeons. Performance of painless surgical procedure is highly appreciated by the patients and is possible through the use of local anesthesia, conscious sedation or general anesthesia. Postoperative pain can also be controlled by the use of opioids, as opioid receptors exist in the peripheral nervous system and offers the possibility of providing postoperative analgesia in the surgical patient. The present study compares the efficacy of 0.5% bupivacaine versus 0.5% bupivacaine with 0.3 mg buprenorphine in minor oral surgical procedures.Patients and Methods:The present study was conducted in 50 patients who required minor oral surgical procedures under local anesthesia. Two types of local anesthetic solutions were used- 0.5% bupivacaine with 1:200000 epinephrine in group I and a mixture of 39 ml of 0.5% bupivacaine with epinephrine 1:200000 and 1 ml of 300 μg buprenorphine (3 μg/kg)in group II. Intraoperative and postoperative evaluation was carried out for both the anesthetic solutions.Results:The mean duration of postoperative analgesia in bupivacaine group (508.92 ± 63.30 minutes) was quite less than the buprenorphine combination group (1840.84 ± 819.51 minutes). The mean dose of postoperative analgesic medication in bupivacaine group (1.64 ± 0.99 tablets) was higher than buprenorphine combination group (0.80 ± 1.08 tablets). There was no significant difference between the two groups regarding the onset of action of the anesthetic effect and duration of anesthesia.Conclusion:Buprenorphine can be used in combination with bupivacaine for patients undergoing minor oral surgical procedures to provide postoperative analgesia for a longer duration.

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Section: Discussionsupporting

confidence: 89%

Use of 0.5% bupivacaine with buprenorphine in minor oral surgical procedures

Nagpal¹,

Kaur²,

Kapila³

et al. 2017

Natl J Maxillofac Surg

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“…From 2001 onward, eight studies[ 5 6 7 8 9 10 13 14 ] have reported significantly long duration of analgesia using buprenorphine in brachial plexus block. However, only three[ 6 10 13 ] out of eight studies had systemic control group.…”

Section: Discussionmentioning

confidence: 99%

“…However, only three[ 6 10 13 ] out of eight studies had systemic control group. Rest five studies[ 5 7 8 9 14 ] had placebo control group where plain LAs were used for the block. In 2008, Jadon et al [ 13 ] studied the effect of the addition of 3 μg/kg buprenorphine to 0.3% bupivacaine in subclavian perivascular block.…”

Section: Discussionmentioning

confidence: 99%

“…In five out of eight above-mentioned studies, fixed dose of buprenorphine was used. In four studies,[ 5 6 7 14 ]300 μg and in one study[ 10 ]150 μg of buprenorphine was used. In three[ 8 9 13 ] out of eight above-mentioned studies, 3 μg/kg buprenorphine was used.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 5 ] In the majority of the studies with buprenorphine as a local anesthetic (LA) adjuvant, either a fixed dose of 300 μg or 3 μg/kg has been used. [ 6 7 8 9 ] Very few studies[ 10 ] till date have been done to evaluate the effect of the lower dose of buprenorphine (2 μg/kg) as an LA adjuvant. Hence, this placebo-controlled trial was undertaken to compare the effect of regional (axillary brachial plexus block [ABPB]) versus intramuscular (IM) administration of buprenorphine (2 μg/kg) in adults undergoing upper limb surgeries.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Buprenorphine for postoperative analgesia: Axillary brachial plexus block versus intramuscular administration in a placebo-controlled trial

Thakur

Malde

2015

J Anaesthesiol Clin Pharmacol

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Background and Aims:Peripheral administration of opioids has been suggested for prolongation of regional analgesia. This prospective, randomized, double-blind placebo-controlled study was undertaken to compare the effect of regional (axillary brachial plexus block [ABPB]) versus intramuscular (IM) buprenorphine (2 μg/kg) in adults.Material and Methods:Seventy-five adults undergoing upper limb surgery received ABPB with local anaesthetic (15 ml 0.5% bupivacaine, 15 ml 2% lignocaine with adrenaline 1:200,000, 9 ml normal saline [NS]). In addition, regional group RB (n = 25) received buprenorphine 2 μg/kg in ABPB and 1 ml NS IM. Systemic Group SB (n = 25) received 1 ml NS in ABPB and buprenorphine 2 μg/kg IM. Group C (n = 25) received 1 ml NS in ABPB and IM. Onset, duration of sensory and motor block, hemodynamic parameters, sedation score, pain scores using visual analog scale, duration of postoperative analgesia, rescue analgesic (RA) requirement, adverse events, and patient satisfaction were noted.Results:Demographics, onset and duration of sensory, motor block were similar. RB group had longest duration of analgesia (20.61 ± 1.33 h) compared to SB (10.91 ± 0.90 h) and control group (5.86 ± 0.57 h) (P < 0.05 RB vs. SB/C and SB vs. C). RA requirement was highest in the control group and least in RB group (P = 0.000 RB vs. SB/C and SB vs. C). SB group had a maximum number of side effects (P = 0.041, SB vs. RB/C). Patient satisfaction was highest with group RB (P < 0.05 RB vs. SB/C, and P = 0.06 SB vs. C).Conclusion:Buprenorphine 2 μg/kg in axillary plexus block provides significantly prolonged analgesia with less RA requirement and greater patient satisfaction compared to IM administration. This is highly suggestive of action on peripheral opioid receptors.

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Effect of Dexamethasone as an Adjuvant To 0.5% Bupivacaine in SupraclavicularBrachial Plexus Block- A Randomized Study.

Padmaja¹,

Jaganath²,

Srinivasan³

et al. 2019

AAN

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Background: Aims and Objectives: To study the effects of addition of Dexamethasone to Bupivacaine with respect to onset, duration of sensory and motor blockade, haemodynamic variables and rescue analgesics used in first 24 hours. Subjects and Methods: A prospective, randomized, study of 100 patients of ASA I &II, aged between 20-60years were included. Patients were randomized to two groups, 50 of bupivacaine group (B) and 50 of bupivacine and dexamethasone (BD). Brachial plexus block was performed via supracalvicular route using ultrasound machine. The onset of anesthesia, loss of sensory perception and temperature was recorded. The patients were also monitored for any side effects or complications. The data obtained was analyzed using (SPSS vs 18). Quantitative data were analyzed by using student 't' test, Qualitative by using Chi -Square test. p value of less than 0.05 was considered as statistically significant. Results: Demographics were comparable between the groups. The mean onset of sensory block [10.3 Vs 16.7] and motor block [5.6±0.7 Vs8.6±1.2] was earlier in BD group. Similarly the mean duration of sensory block in hours [5.9±0.67 Vs 4±6.3] and motor block was [4.3±0.9 Vs1.9±0.5]. The group BD received less rescue analgesics. There was a significant fluctuation in systolic blood pressure in group B. Conclusion: Use of dexamethasone as an adjuvant to bupivacaine in supraclavicular brachial plexus block results in faster onset of action of sensory and motor blockade. It also results statistically significant longer duration of sensory and motor blockade.

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Buprenorphine as an adjuvant in supraclavicular brachial plexus block.

Cited by 4 publications

References 14 publications

Use of 0.5% bupivacaine with buprenorphine in minor oral surgical procedures

Use of 0.5% bupivacaine with buprenorphine in minor oral surgical procedures

Buprenorphine for postoperative analgesia: Axillary brachial plexus block versus intramuscular administration in a placebo-controlled trial

Effect of Dexamethasone as an Adjuvant To 0.5% Bupivacaine in SupraclavicularBrachial Plexus Block- A Randomized Study.

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