Buprenorphine exposure in infants of opioid‐dependent mothers at birth

Bartu, Anne; Ilett, Kenneth F.; Hackett, L.P.; Doherty, Dorota; Hamilton, Dale

doi:10.1111/j.1479-828x.2012.01424.x

Cited by 15 publications

(22 citation statements)

References 23 publications

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“…This treatment had been found to effectively improve the neonatal outcomes of substance‐dependent mothers . Consistently, the evidence resulting from this review illustrated that early commencement and adherence to methadone or buprenorphine treatment may reduce the adverse effects of illicit substance use during pregnancy …”

Section: Discussionsupporting

confidence: 63%

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Short‐term health outcomes of newborn infants of substance‐using mothers in Australia and New Zealand: A systematic review

Oni

Khan

Abdellatif

et al. 2019

J of Obstet and Gynaecol

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Aim Substance use is not unusual among women of childbearing age. Pregnant women who use a substance and the consequent impacts on a newborn vary across studies and settings. We reviewed New Zealand and Australian literature to examine the short‐term health outcomes of newborn of substance‐using mothers and their demographic characteristics. Methods Five medical/nursing databases and google scholar were searched in April 2017. Studies were considered eligible if they described outcomes of newborn of substance‐using mothers. Mixed Methods Appraisal Tool was used for quality assessment of candidate studies. Relevant data were extracted and analyzed using narrative synthesis. Based on data availability, a subset of studies was included in meta‐analysis. Results Although findings of individual studies vary, there are some evidence that the infants born to substance‐using mothers were likely to have preterm birth, low birthweight, small‐for‐gestational age, low Apgar score, and admission to neo‐natal intensive care unit. The likelihood of adverse health outcomes was much higher for newborns of polysubstance‐using mothers, than newborns of mothers using a single substance. Pregnant women who use illicit substance are predominantly socially disadvantaged, in their twenties and or of Aboriginal descent. Conclusion Infants of substance‐using mothers suffer a range of adverse health outcomes. Multidisciplinary and integrated approach of services that ensure supportive social determinants of health may result in a better outcome for newborn and positive behavioral change among mothers.

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Section: Discussionsupporting

confidence: 63%

“…An audit conducted in a chemical dependency unit in a hospital in Melbourne found more neonatal problems requiring specialized medical and nursing expertise, compared with control infants . Polysubstance use was found to be a significant factor for neonatal abstinence syndrome …”

Section: Resultsmentioning

confidence: 99%

Short‐term health outcomes of newborn infants of substance‐using mothers in Australia and New Zealand: A systematic review

Oni

Khan

Abdellatif

et al. 2019

J of Obstet and Gynaecol

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“…Jones et al 2005) and lower buprenorphine doses (e.g. Simmat-Durand et al 2009, Bartu et al 2012), respectively. In regard to average daily SROM doses at time of delivery, no data from other treatment centers are available for comparison.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and quality of life of opioid-dependent pregnant women in Austria

Metz

Comer

Wuerzl

et al. 2014

Arch Womens Ment Health

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“…Both of these values were considered low and there was also low transfer of the drug into fetal circulation (cord blood values: 0.4 mg/L of buprenorphine and 1.2 mg/L of norbuprenorphine. 61 The concentration of buprenorphine in the breast milk has been examined. The breast milk of 1 women receiving 4 mg/d of buprenorphine contained 3.28 mg/d of buprenorphine.…”

Section: Buprenorphinementioning

confidence: 99%

Breastfeeding and Substance Abuse

DʼApolito

2013

Clinical Obstetrics &Amp; Gynecology

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Breastfeeding is the recommended feeding method for infants. The decision to allow women to breastfeed while consuming alcohol and other drugs postpartum presents a problem for the health care provider. This article discusses the biochemical properties of various drugs as they relate to breastfeeding. Women in a methadone treatment program should be allowed to breast feed; however, more research is needed to determine the efficacy of breastfeeding when women are receiving buprenorphine. Breastfeeding should not be recommended in women who abuse heroin recreationally until more information is known about the actual amount of morphine present in the breast milk.

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Buprenorphine exposure in infants of opioid‐dependent mothers at birth

Abstract: Usual therapeutic doses of buprenorphine administered to pregnant women resulted in low concentrations of buprenorphine and norbuprenorphine in maternal serum and a low transfer to the fetal circulation (cord plasma) at birth.

Cited by 15 publications

References 23 publications

Short‐term health outcomes of newborn infants of substance‐using mothers in Australia and New Zealand: A systematic review

Short‐term health outcomes of newborn infants of substance‐using mothers in Australia and New Zealand: A systematic review

Characteristics and quality of life of opioid-dependent pregnant women in Austria

Breastfeeding and Substance Abuse

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