Bupropion abuse resulting in hypomania in a geriatric amphetamine user: A case report

Rostas, Aviva; Wolf, Uri

doi:10.1111/ajad.12308

Cited by 7 publications

(6 citation statements)

References 6 publications

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Section: Comorbiditiesmentioning

confidence: 89%

“…The most common psychiatric condition seen in our case report synthesis was substance use disorder, which included cocaine (six cases) [24,26,27,30,37], opioids (three cases) [20,26,34], amphetamines/methamphetamine (three cases) [27,36,37], and alcohol (three cases) [26,31,37]. Other psychiatric comorbidities and clinical signs comprised bipolar disorder (three cases) [20,25,37] and depression (seven cases) [20,[26][27][28]30,36,39]. Conduct disorder [38], ADHD [32], schizoaffective disorder [24,28], social anxiety disorder [35], panic disorder [30], antisocial personality disorder [28], pathological gambling [37], post-traumatic stress disorder [25], and unassessed auditory hallucinations [35] were reported in one or two cases.…”

Section: Comorbiditiesmentioning

confidence: 92%

“…The most common route for bupropion use was nasal insufflation (seen in 11 cases ) [24][25][26][27][28][29][30][31][32][33][34], followed by the oral route (seen in seven cases) [35][36][37][38]. IV administration was observed in two cases [20,39], while two other cases did not report the route of administration [28,40].…”

Section: Pattern Of Usementioning

confidence: 99%

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A Systematic Review of Abuse or Overprescription of Bupropion in American Prisons and a Synthesis of Case Reports on Bupropion Abuse in American Prison and Non-prison Systems

Aikoye¹,

Basiru²,

Nwoye³

et al. 2023

Cureus

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Illicit drug use is a huge problem in the US prison system. The objectives of this study are (1) to systematically investigate the prevalence of bupropion abuse in American prisons along with associated problems, and (2) to synthesize available case reports on this topic in both prison and non-prison settings. Using the Preferred Reporting Items for Systematic Reviews and Meta-analyses, we searched five databases (PubMed, Embase, Scopus, CINAHL, and PsycINFO) and used Covidence software for screening and reviewing identified articles. The final search date was February 21, 2023. Newcastle-Ottawa Scale and ROBINS-I tool were used for risk of bias assessment. We included original studies of populations aged 18 years and above in American prisons. We found 77 unique articles, none of which met our eligibility criteria. A synthesis of 22 case reports that we found showed bupropion abuse to be more common in young males, and intranasal administration was the most common method of abuse. More frequent desired and adverse effects were "cocaine-like highs" and seizures, respectively. Although several cases of bupropion abuse have been reported in US prisons, no study has been done to understand its prevalence and associated effects. The absence of original studies on bupropion abuse in US prisons and the observed patterns in this case report synthesis further highlight the need for a study to investigate the prevalence of bupropion abuse in US prisons. The limitations of this study include that it is an empty systematic review and the absence of all pertinent data in many of the included case reports. The authors did not receive any funding for this work. This systematic review was registered in PROSPERO with registration number CRD42021227561.

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Section: Comorbiditiesmentioning

confidence: 89%

Section: Comorbiditiesmentioning

confidence: 92%

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A Systematic Review of Abuse or Overprescription of Bupropion in American Prisons and a Synthesis of Case Reports on Bupropion Abuse in American Prison and Non-prison Systems

Aikoye¹,

Basiru²,

Nwoye³

et al. 2023

Cureus

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“…For instance, in the last 20 years, published case reports/series have described the misuse of gabapentin, 27 quetiapine, [28][29][30] venlafaxine, 31 and bupropion. 32,33 These types of case reports/series can alert providers of the potential for misuse of some of the commonly prescribed medications in psychiatry.…”

Section: The Role Of Case Reports/series In Questions Of Diagnosis Et...mentioning

confidence: 99%

The Role of Case Series and Case Reports in Evidence-Based Medicine

Smith,

Patel

2024

J Clin Psychopharmacol

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“…Although originally considered unlikely [10,11], some recent reports of bupropion abuse, especially among young adults and adolescents, have been published. At present, ten peer-reviewed articles in which ''bupropion abuse'' is mentioned in the title of the article can be found in PubMed (accessed 11 December 2015) [10,[12][13][14][15][16][17][18][19][20]. Half of these articles were published in the last 3 years.…”

Section: Introductionmentioning

confidence: 99%

The relationship between bupropion and suicide in post-mortem investigations

Kriikku

Ojanperä

2016

Forensic Science International

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We reviewed the 33727 postmortem toxicology investigations performed in Finland over a period of 5years (2009-2013) and identified those in which the antidepressant bupropion was detected. Cases positive for other antidepressant drugs were reviewed for comparison. The postmortem toxicological examination included, in all cases, the routine screening and quantification of hundreds of drugs and poisons using quality-controlled methods. Bupropion was detected in 65 cases. A large proportion of the bupropion-positive deaths resulted from suicide (55%). In fatal poisoning cases found positive for bupropion, the proportion of suicide was even higher (77%). The measured median bupropion postmortem blood concentration (0.69mg/L) was markedly higher than the normal therapeutic range in plasma in the treatment of depression (up to 0.1mg/L) and even higher in fatal bupropion poisonings (13mg/L). Only 14% of the deceased positive for bupropion were estimated to be drug abusers. However, nearly all of the drug abuse cases were from the last year of the study (2013), indicating a recent increase of the use of bupropion among drug abusers and possibly even abuse of bupropion itself. Suicide victims positive for bupropion were younger than those who died with other antidepressant drugs in their blood. In addition, the percentage of fatal poisonings among bupropion-positive postmortem cases was higher than among the users of other antidepressant drugs. Suicide was significantly more common among the deceased positive for bupropion than among users of other antidepressant drugs. An unknown degree of bupropion degradation before the assay and post-mortem redistribution of bupropion may have impacted the measured levels. Nonetheless, all post-mortem concentrations of bupropion were elevated and especially high concentrations were detected in suicides.

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Bupropion abuse resulting in hypomania in a geriatric amphetamine user: A case report

Abstract: This case emphasizes the need to consider bupropion's abuse potential when prescribing it to older adults with risk factors for substance abuse.

Cited by 7 publications

References 6 publications

A Systematic Review of Abuse or Overprescription of Bupropion in American Prisons and a Synthesis of Case Reports on Bupropion Abuse in American Prison and Non-prison Systems

A Systematic Review of Abuse or Overprescription of Bupropion in American Prisons and a Synthesis of Case Reports on Bupropion Abuse in American Prison and Non-prison Systems

The Role of Case Series and Case Reports in Evidence-Based Medicine

The relationship between bupropion and suicide in post-mortem investigations

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