Bupropion induces social anxiety in adolescent mice: Influence of housing conditions

Gómez, Camila Ortiz; Redolat, Rosa; Carrasco, Claudia

doi:10.1016/j.pharep.2017.03.010

Cited by 7 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An exhaustive analysis of the behavioral repertoire exhibited by the animals during the agonistic encounters allows us to detect not only the antiaggressive effects of the drug, but also anxiolytic/anxiogenic effects and motor affectation by the administered substance (Brain et al, 1991;Gómez et al, 2017;Krsiak et al, 1984;. Thus, the antiaggressive effect observed after the lowest dose of PMA (2 mg/kg) administered is not specific.…”

Section: Discussionmentioning

confidence: 99%

“…Non-social exploration behaviors were increased after 2 mg/kg of PMA treatment, while a reduction in digging behavior was observed. Increases in digging behaviors have been reported after the administration of anxiolytic substances (Cutler et al, 1997), and reductions in digging have been related to anxiogenic actions of several compounds (Gómez et al, 2017;. Additionally, an increase in time spent in non-social exploration, taking into account the behavioral profile observed, could be indicative of an attempt to escape the test (Maldonado and Navarro, 2001).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice

Martı́n-López

Muela

Cavas

et al. 2018

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice

Martı́n-López

Muela

Cavas

et al. 2018

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

“…e conclusion shows that CBGT can effectively improve the symptoms of adolescents' social anxiety and improve the self-efficacy of emotion regulation. However, due to the complex process, the treatment cycle is long [14].…”

Section: Related Workmentioning

confidence: 99%

“…ese two factors are two extremes of the same variables. Whether the variable is a certain factor depends on the score of the corresponding variable of the adolescent individual, not the attribute of the variable itself [14]. erefore, the risk factors and protective factors in the growth process of teenagers are screened out from all factors in formula (1).…”

Section: Vector Acquisition Of the Weight Of Adolescent Socialmentioning

confidence: 99%

Prediction of Cognitive-Behavioral Therapy using Deep Learning for the Treatment of Adolescent Social Anxiety and Mental Health Conditions

Zheng

Yang²

2022

Scientific Programming

View full text Add to dashboard Cite

Cognitive-behavioral therapy is a type of psychosocial intervention which aims to reduce the mental health conditions like depression, anxiety disorder, and others. Similarly, deep learning is a type of machine learning and artificial intelligence that imitates how humans gain certain types of knowledge. In this paper, deep learning has been used to effectively alleviate teenagers’ social anxiety and improve their social ability and the quality of social relations. It aims to conduct an in-depth study on the diagnosis and treatment of cognitive behavior therapy in teenagers based on deep learning. First, it constructs the cognitive behavior diagnosis and treatment evaluation system of adolescent social anxiety and divides the system function into functional, structural, and database design. Then, the correlation prediction model between cognitive behavior therapy and adolescent social anxiety is constructed based on a multiobjective evolutionary algorithm. The risk and protective factors in adolescent growth are screened from the perspectives of people, family, school, and society. The fuzzy itemset support of different factors is defined. The vector of adolescent social anxiety expression index’s weight is calculated. The subjective and objective factors of social anxiety in adolescents are extracted based on the grey correlation degree. The correlation prediction model between accurate cognitive behavior therapy and adolescents’ social anxiety is established to complete the prediction research, diagnosis, and treatment effect. Simulation experiments show that the proposed method has good feasibility and high prediction accuracy. It can effectively alleviate the social anxiety of teenagers.

show abstract

“…In laboratory SI housing conditions, animals are housed in standard cages singly for continuous periods of time with no opportunities for social contact. Social component of the housing environment strongly impacts mice (Gómez et al, 2017), and SI can result in hyperactivity and increased anxiety‐like behaviour in animals with the disrupted function of monoamine systems (Walker et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Long‐lasting housing environment manipulation and acute loss of environmental enrichment impact BALB/c mice behaviour in multiple functional domains

Sukegawa

Yoshihara

Hou

et al. 2022

Eur J of Neuroscience

View full text Add to dashboard Cite

Understanding environmental influences on individuals' behaviour is challenging. Here we have investigated the housing impact of 9 weeks of enriched environment (EE) and social isolation (SI) and the impact of abrupt deprivation of EE (enrichment removal: ER) on BALB/c mice. Compared with the widely used C57BL/6 strain in research, BALB/c synthesises serotonin less efficiently due to a genetic variation and thus may potentially represent human populations at higher risk of stress‐related disorders. We assessed the effects of EE and SI by conducting a behavioural test battery and the effects of acute ER by monitoring homecage activities and social behaviour. We found that EE and SI impact BALB/c's physiological states and behavioural performances from lower to higher cognitive processes: increased body weight, increased rectal temperature, altered performance in motor and sensory tasks, the activity level in a novel environment and altered performance in tests of anxiety‐like behaviour, stress‐coping strategies and learning and memory. Furthermore, acute ER triggered stress/frustration‐like behaviour in BALB/c, with increased aggression, increased social distancing and disrupted daily/nightly activities. Our results demonstrate that long‐lasting housing manipulation such as EE and SI, impact behaviour via multilayered processes over a wide range of functional domains, and unforeseen change to a negative environment, ER, is a major stressor that causes behavioural and psychological consequences through environment–gene interactions, a model of direct relevance to human health.

show abstract

Bupropion induces social anxiety in adolescent mice: Influence of housing conditions

Cited by 7 publications

References 40 publications

Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice

Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice

Prediction of Cognitive-Behavioral Therapy using Deep Learning for the Treatment of Adolescent Social Anxiety and Mental Health Conditions

Long‐lasting housing environment manipulation and acute loss of environmental enrichment impact BALB/c mice behaviour in multiple functional domains

Contact Info

Product

Resources

About