“…In Smokeless group it was 28.1% at week 6, 8 and 12 in pharmacotherapy group and 50%, 53.8% and 53.8% respectively in combined therapy group while in smokers abstinence rate at 6, 8 and 12 week was 16.7%, 33.3% and 33.3% respectively in pharmacotherapy group and 45.5%, 54.5% and 54.5% in combined therapy group. We found varied result in other studies like study by Tonstad et al (2003) of 629 subjects, it has been found that the continuous abstinence rates from week 4 to 26 and 4 to 52 continued to be more than double for bupropion SR compared with placebo (27 vs 11%; 22 vs 9%). Another randomized, placebo-controlled trial of 509 smokers, Aubin et al (2004) revealed that the continuous abstinence rates in bupropion group and placebo group were 41% and 21% for week 4 to 7, and 25% and 13% for weeks 4 to 26, respectively.…”