Burchellin: study of bioactivity against Aedes aegypti

Narciso, Juliana Oliveira Abreu; Soares, Renata Oliveira; Mallet, Jacenir Reis dos Santos; Guimarães, Anthony Érico; Chaves, María Célia de Oliveira; Barbosa-Filho, José Maria; Maleck, Marise

doi:10.1186/1756-3305-7-172

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…However, the results reported here about O. quixos (LD99 = 181.89 ppm) are consistent with findings on Ocotea cymbarum, showing that its strongest toxic effect was 100% mortality in Ae. aegypti third age larvae at concentrations !30 ppm [23]. Previous studies on the monoterpene 1,8-cineole, which is the main constituent of O. quixos oil in this experiment, showed larvicidal activity toward the larvae of several mosquitos including Ae.…”

Section: Anti-larval Effects Of Essential Oilssupporting

confidence: 51%

Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti

et al. 2019

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Aedes aegypti, the main arbovirus vector of the Yellow fever, Dengue, Chikungunya and Zika viruses, is widely distributed in tropical and subtropical areas throughout the world. Preventive control efforts have been implemented worldwide aimed at reducing its impact on human health. The recent reduction of chemicals available for vector control due to their negative impact on the environment and human health and the increase in mosquito resistance to insecticides have driven the research community to identify and evaluate sustainable alternatives to synthetic insecticides. In this study, the potential larvicidal effect of essential oils extracted from Ocimum campechianum, Ocotea quixos and Piper aduncum were tested in vitro. GC and GC–MS analyses showed that the main compounds were eugenol (18%), 1,8-cineole (39%) and dillapiole (48%), respectively. Susceptibility to essential oils was measured according to the WHO protocol. After 24 h, the mean percentage mortality ranged from 2.7 to 100% for P. aduncum, from 2.2 to 100% for O. campechianum, and from 2.9 to 100% for O. quixos. The highest potential was displayed by P. aduncum, followed by O. campechianum and O. quixos, with LC50 values of 25.7, 69.3 and 75.5 ppm, respectively. The rapid and effective larvicidal activity of these three oils led us to consider these results to be promising, also considering the possibility of local cultivation of these plants in tropical and subtropical areas and the simple technology for their large-scale preparation and production. Further studies are needed to evaluate the individual components and their activity as larvicides.

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Section: Anti-larval Effects Of Essential Oilssupporting

confidence: 51%

Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti

et al. 2019

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“…Certain plant preparations are toxic to different mosquito species larvae 19–22 and have therefore been proposed to be alternatives to conventional larvicides. Active larvicidal constituents (LC 50 < 50 mg/L 39 ) derived from plants include alkaloids (e.g., retrofractamide A and three isobutylamides 40 , 0.004–0.86 mg/L), terpenoids (e.g., 9-oxoneoprocurcumenol and neoprocurcumenol 41 , 5.81 and 13.69 mg/L), coumarins (e.g., imperatorin and eight coumarins 26 , 2.88–44.39 mg/L), flavonoids (e.g., karanjin, karanjachromene, pongamol, and pongarotene 42 , 14.61–37.61 mg/L), phenylpropanoids (e.g., ethyl p -methoxycinnamate 43 , 12.3–20.7 mg/L), lignans (e.g., (−)-asarinin 25 , 10.49–16.49 mg/L), neolignans (e.g., burchellin 44 , 15.5 mg/L), cyanogenic glycosides (e.g., dhurrin 45 , 12 mg/L), lactones (e.g., butenolides 1 and 2 46 , 0.41 and 0.47 mg/L), acetylenic alcohols (e.g., falcarinol and falcarindiol 47 , 3.49 and 6.51 mg/L), and fatty acids (e.g., oleic acid and palmitic acid 42 , 18.07–18.45 and 34.50–42.96 mg/L). Kiran et al .…”

Section: Discussionmentioning

confidence: 99%

Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species

Wang

Perumalsamy

Xue

et al. 2019

Sci Rep

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This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC50, 6.13–7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure–activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H+-ATPase and aquaporin 4, indicating that it may disturb the Na+, Cl− and K+ co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.

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“…Histological tests were performed in accordance with the method of Narciso et al [19] with slight modifications. Larvae treated with different concentrations of bruceine A, 1 ppm of temefos, or distilled water were fixed in 2.5% glutaraldehyde in sodium cacodylate buffer (0.1 M, pH 7.4) for 4 h. Samples were then dehydrated in a gradient ethanol series (70%, 80%, 90% 96%, and 100%).…”

Section: Histological Testmentioning

confidence: 99%

“…Narciso et al [19] reported that histomorphological changes resulted from treatment with burchelin from Ocotea cymbarium caused the death of L3-L4 larvae of A. aegypti. The midgut epithelial cells of the larvae exhibited disorganization, damage, and vacuolization.…”

Section: Histological Changes Of a Aegypti (L) Larvaementioning

confidence: 99%

Morphological and Histological Effects of Bruceine a on the Larvae of Aedes Aegypti Linnaeus (Diptera: Culicidae)

Sutiningsih

Mustofa

Satoto

et al. 2018

Asian J Pharm Clin Res

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Objective: This study aimed to determine a target of action of bruceine A on the basis of its morphological and histological effects on the larvae of Aedes aegypti Linnaeus.Methods: Bruceine A was isolated from Brucea javanica (L.) Merr. seeds in accordance with the Mangungsong method. Larvae of A. Aegypti (L.) in instar III to the beginning of instar IV were treated with various concentrations of bruceine A. The negative control group did not receive any treatment, whereas the positive control group received 1 ppm temefos. Dead larvae were collected after 24 h of treatment for the examination of morphological and histological changes.Results: The negative control group did not exhibit any morphological and histological changes. Larvae treated with bruceine A, however, had visible damaged heads, cuticles, digestive and respiration tracts, respiratory siphons, and setae, and they were smaller than normal larvae. Larvae treated with temefos exhibited gastrointestinal damage, narrowed breathing tubes, cuticle damage, and detached/damaged seta feathers. The necrosis of gastrointestinal epithelial cells was the major histological change exhibited by larvae treated with various concentrations of bruceine A or 1 ppm temefos.Conclusion: The targets of action of bruceine A in A. aegypti (L.) larvae are the head/caput, cuticle, setae, siphon, and gastrointestinal and respiratory tracts.

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Burchellin: study of bioactivity against Aedes aegypti

Cited by 15 publications

References 28 publications

Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti

Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti

Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species

Morphological and Histological Effects of Bruceine a on the Larvae of Aedes Aegypti Linnaeus (Diptera: Culicidae)

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