Burden and trends of brain and central nervous system cancer from 1990 to 2019 at the global, regional, and country levels

Abstract

Background Regularly updated epidemiological data on the burden of brain and central nervous system (CNS) cancers are important in the prioritization of research and the allocation of resources. This study aimed to investigate incidence, mortality, disability, and trends in brain and CNS cancers between 1990 and 2019. Methods Epidemiological data, including the cancer incidence, mortality, disability-adjusted life years(DALYs), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALY rate (per 100,000 population) stratified by region, country, sex, and age group were retrieved and extracted using the Global Health Data Exchange (GHDx) query tool. Results In 2019, there were 347,992(262,084–388,896) global cases of brain and CNS cancers, which showed a significant increase (94.35%) from the period between 1990 to 2019. The global ASIR in 2019 was 4.34 (3.27–4.86) per 100, 000 population, which showed an increasing trend for the years 1990–2019 (13.82% [-27.27–32.83]). In 2019, there were 246,253 (185,642–270,930) global deaths caused by brain and CNS cancers, which showed a significant increase (76.36%) during the study period. The global ASMR in 2019 was 3.05(2.29–3.36) per 100, 000 population, which did not change significantly over the study period (-1.19% [-36.79–13.86]). In 2019, there were 8,659,871 DALYs, which was a 109.04% increase compared with 1990. Similarly, during 1990–2019, the age-standardized DALY rate decreased by 10.39%. Additionally, 76.60% of the incident cases, 72.98% of the deaths, and 65.16% of the DALYs due to brain and CNS cancers occurred in the high-income and upper-middle-income regions. Conclusions In conclusion, brain and CNS cancers remain a major public health burden, particularly in high-income regions. The global incidence, deaths, and DALYs of brain and CNS cancers were shown to have increased significantly from 1990 to 2019. The global ASIR kept rising steadily, while the ASMR and age-standardized DALY rate declined over the past three decades. Supplementary Information The online version contains supplementary material available at 10.1186/s13690-022-00965-5.

Exploring Monocytes-Macrophages in Immune Microenvironment of Glioblastoma for the Design of Novel Therapeutic Strategies

“…Brain and other nervous system cancers are among the most fatal cancers in several countries around the world [ 1 , 2 , 3 ]. In 2019, there were 347,992 global cases of brain and Central Nervous System (CNS) cancers, which showed a significant increase in its incidence (94.35%) from the period between 1990 to 2019 [ 4 ]. An estimated 251,329 people passed away from primary cancerous brain and central nervous system (CNS) tumors in 2020 [ 5 ].…”

Raman Spectroscopy: A Tool for Molecular Fingerprinting of Brain Cancer

“…There were 308,102 new cases and 251,329 fatalities due to brain and CNS cancers worldwide in 2020, according to the GLOBOCAN 2020 report . Also, brain cancer has one of the lowest 5% year survival rates among all other cancer types .…”

“…2 There were 308,102 new cases and 251,329 fatalities due to brain and CNS cancers worldwide in 2020, according to the GLOBOCAN 2020 report. 3 Also, brain cancer has one of the lowest 5% year survival rates among all other cancer types. 4 These statistics and the complexity of brain tumors clearly signify the requirement for better diagnostics, monitoring, and treatment techniques.…”

Preliminary Exploration of Structure‒Function Crosstalk in Glioma: Protein Structuromics

“…Currently, approximately 33% of all brain tumours are gliomas, which originate in the glial cells, including astrocytes, oligodendrocytes, and ependymal cells 3 . According to the Fan group investigation, from 1990 to 2019, 347,992 global cases of brain and CNS cancers occurred, 46.12% in female patients and 53.88% in male patients (deaths: 43.71% vs. 56.29%; disability-adjusted life years (DALYs): 42.11% vs. 57.89%) 4 . The average cost of a craniotomy was $10,042 across studies.…”