Burden of Aortic Aneurysm and Its Attributable Risk Factors from 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019

Abstract

BackgroundGlobal and national estimates on the epidemiology of aortic aneurysms are prerequisites for disease management and policymaking. Based on the Global Burden of Disease (GBD) 2019, this study aimed to discern the global aortic aneurysm burden by systematically analyzing demographic data on mortality and exploring the attributable risks and relevant factors.MethodsThe data analyzed in this study were available in the Global Health Data Exchange (GHDx) online query tool. The population in our study comprised individuals from 204 countries and territories from 1990 to 2019. The estimated annual percentage changes (EAPCs) were performed to assess the temporal trends of aortic aneurysms and their attributable risks. Spearman correlation analysis was performed to explore the relationship between the burden of aortic aneurysm and covariates.ResultsAlthough aortic aneurysm-related deaths (82.1%) and disability-adjusted life years (DALYs) (67%) increased from 1990 to 2019, the global trend of age-standardized rate of death (ASRD) (EAPC: −1.34, 95% CI = −1.46 to −1.22, P < 0.001) and age-standardized rate of DALY (ASDALYR) (EAPC: −1.06, 95% CI = −1.17 to −0.95, P < 0.001) decreased, both of which presented age dependence and gender differences. Smoking and high systolic blood pressure (SBP) were the main attributable risks of disease burden and tend to decease globally (EAPC: −1.89, 95% CI = −2.03 to −1.89, P < 0.001; −1.31 95% CI = −1.43 to −1.19, P < 0.001, respectively). Alcohol abstinence (male: R = −0.71, P < 0.001; female: R = −0.73, P < 0.001), smoking age of initiation (male: R = −0.32, P < 0.001; female: R = −0.50, P < 0.001), physical activity (male: R = −0.50, P < 0.001; female: R = −0.55, P < 0.001), and mean temperature (R = −0.62, P < 0.001) had negative correlation with ASRD. However, cholesterol level (male: R = 0.62, P < 0.001; female: R = 0.39, P < 0.001), body mass index (BMI) (male: R = 0.30, P < 0.001; female R = −0.01, P > 0.05), and alcohol consumption (male: R = 0.46, P < 0.001; female: R = 0.42, P < 0.001) had a positive correlation with ASRM. Besides, standard of living and medical resources positively related to burden of aortic aneurysm.ConclusionIn this study, a decreasing trend of aortic aneurysm burden was found globally, especially in advanced regions. Aged men who smoke and women who have hypertension should pay close attention to, particularly in deprived economic groups, and many approaches can be performed to reduce the burden of aortic aneurysms.

Ascending aortic aneurysm and histopathology in Alport syndrome: a case report

“…Definitive proof for the contributions of such skewed X-inactivation to AS phenotype in females has not yet been achieved and is an active area of study [ 20 ]. Aortic aneurysm in the absence of AS or other underlying genetic risk factor is much more prevalent in elderly subjects reflecting the progressive and accumulative influence of other known risk factors (hypertension, atherosclerosis, inflammation) on aortic wall function [ 25 – 27 ].…”

El nutricionista-dietista ante el aneurisma de aorta abdominal

“…The Nutritionist-Dietitian in the Abdominal Aortic Aneurysm O dietista-nutricionista face ao aneurisma da aorta abdominal Rafael Almendra-Pegueros 1,2* , José Martínez-González [2][3][4] , Cristina Rodríguez [1][2][3] , María Galán [1][2][3]5 https://doi.org/10.35454/rncm.v5n3.435…”

“…De acuerdo con el informe Global Burden of Disease Study 2019, el aneurisma aórtico (AA) provocó 172 427 muertes durante 2019, observándose un incremento del 82,1 % desde 1990. Este incremento fue inferior en países con mayor índice sociodemográfico (33,47 %), mientras que, en las regiones de menores ingresos y mayores desigualdades sociales, el problema persiste (1,2) . Los AA son dilataciones focalizadas de la aorta que se pueden localizar a nivel del tórax (AA torácico) y a nivel abdominal (AAA), siendo este último el más común (3) .…”

Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture

“…We hypothesise that meaningful cardiovascular measurements can be extracted from UKBB abdominal MRI, and that these measurements may provide new insights into the etiology of a range of cardiovascular disease outcomes including the detection of abdominal aortic aneurysm (AAA) during routine clinical investigations, a condition that continues to be a significant cause of clinical complications and death. 5,6…”

“…We hypothesise that meaningful cardiovascular measurements can be extracted from UKBB abdominal MRI, and that these measurements may provide new insights into the etiology of a range of cardiovascular disease outcomes including the detection of abdominal aortic aneurysm (AAA) during routine clinical investigations, a condition that continues to be a significant cause of clinical complications and death. 5,6 Previous studies have demonstrated that CMR IDPs in the UKBB, including diameter of the ascending and descending aorta 7 and ventricular volumes, 8 have a substantial heritable component. The cross-sectional areas (CSAs) of vessels represent different partitions in the body receiving blood supply and their sizes are associated with variation in blood supply, blood pressure, age and body size.…”