Burden of atopic dermatitis in Japanese adults: Analysis of data from the 2013 National Health and Wellness Survey

Arima, Kazuhiko; Gupta, Shaloo; Gadkari, Abhijit; Hiragun, Takaaki; Kono, Toru; Katayama, Ichiro; Demiya, Sven; Eckert, Laurent

doi:10.1111/1346-8138.14218

Cited by 72 publications

(99 citation statements)

References 41 publications

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“…Ten studies used the SF‐36 to measure QoL; six of these looked at the relationship between SF‐36 scores and disease severity . Five studies found significant correlations between disease severity and the SF‐36, with increased severity associated with poorer QoL.…”

Section: Resultsmentioning

confidence: 99%

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

2020

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Atopic dermatitis (AD) can affect quality of life (QoL) of adult patients in whom the condition can be severe and persistent. There are currently no systematic reviews of the impact of AD on adults. This paper provides the first systematic literature review and meta‐analysis of the impact of AD on QoL in adults. A systematic search was conducted using MEDLINE, Scopus, and Web of Science for articles published until October 2018. Inclusion criteria were a clinical diagnosis of AD, adult patients, and QoL as an outcome measure. Interventions were excluded. A total of 32 studies were included. While QoL was assessed using Dermatology Life Quality Index (DLQI) in 25 studies, there was heterogeneity in the tools used to measure disease severity across studies. Meta‐analysis of the seven studies that used the SCORAD to measure disease severity showed severity to be significantly related to poorer QoL. The remaining 18 studies also showed increased disease severity significantly related to poorer QoL. When compared to healthy controls, AD patients demonstrated significantly lower QoL, but findings were mixed in studies that compared QoL in AD to other skin conditions. The findings highlight the significant impact that AD has on QoL in adults and the need for validated and relevant QoL measures to be implemented in clinical assessments for AD. Areas that require further research include an exploration of gender differences in QoL and the use of longitudinal study designs to explore factors that may cause differences in QoL ratings.

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Section: Resultsmentioning

confidence: 99%

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

2020

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“…In addition, longitudinal analysis showed that patient QoL was associated with patient perception of their skin condition: scores improved in patients who believed their AD had improved, and scores worsened in patients who reported that their AD had worsened . A patient survey of Japanese patients found that health‐related QoL was significantly reduced in patients with AD compared with non‐AD‐matched controls in mental, physical and overall health domains, though no significant difference was observed between patients with moderate/severe AD and patients with mild AD . Patients with AD also reported higher rates of depression, anxiety and sleep disorders than controls as well as higher rates of work impairment and impaired activity .…”

Section: Quality Of Lifementioning

confidence: 99%

“…A patient survey of Japanese patients found that health‐related QoL was significantly reduced in patients with AD compared with non‐AD‐matched controls in mental, physical and overall health domains, though no significant difference was observed between patients with moderate/severe AD and patients with mild AD . Patients with AD also reported higher rates of depression, anxiety and sleep disorders than controls as well as higher rates of work impairment and impaired activity . In addition, the longitudinal, prospective, observational disease registry study (ADDRESS‐J) which focuses on Japanese adult patients with moderate to severe AD found that worse Patient‐Oriented Eczema Measure (POEM) and worse pruritus numerical rating scale (NRS) scores correlated with worse QoL (per the Dermatology Life Quality Index [DLQI]) …”

Section: Quality Of Lifementioning

confidence: 99%

Burden of atopic dermatitis in Asia

Tsai

Rajagopalan

Chu

et al. 2019

The Journal of Dermatology

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Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and eczematous lesions. It is considered one of the most common chronic conditions, with an estimated global prevalence of nearly 230 million. As in the rest of the world, prevalence of atopic dermatitis has been increasing in Asian countries over the last few decades. This increased prevalence in Asian countries has been attributed to factors such as rapid urbanization, increasingly Westernized lifestyles, and improved standards of living and education. As a result, it is important to understand the increasing burden of disease in Asian countries and the differences between the countries in terms of epidemiology, diagnostic criteria, management, quality of life and economic burden.

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“…The severity of disease symptoms, particularly pruritus, correlates with poor quality of life and depression, and results in a substantially negative impact on work productivity and day‐to‐day activities . Recent studies have highlighted the significant disease burden of AD in Japanese patients …”

Section: Introductionmentioning

confidence: 99%

Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS‐J): Baseline characteristics, treatment history and disease burden

Katoh

Saeki

Kataoka

et al. 2019

The Journal of Dermatology

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Moderate to severe atopic dermatitis ( AD ) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long‐term disease control in the Japanese population. ADDRESS ‐J is a non‐interventional, observational registry of adult Japanese patients with moderate to severe AD . Herein, we report baseline data from the ADDRESS ‐J study describing disease characteristics and current treatment practices. At baseline, 300 adult AD patients with Investigator's Global Assessment ( IGA ) scores (range, 0–4) of 3 (moderate) or 4 (severe) whose treatments for AD were intensified, were assessed for clinical and patient‐reported outcomes and current AD treatments. The registry patients’ median age was 34.0 years; 60.7% were male and 71.7% had had AD for more than 20 years. At baseline, 220 study patients had an IGA score of 3 and 80 had an IGA score of 4. The median Eczema Area and Severity Index score was 21.7 (range, 0–72), the median body surface area involvement was 46.25%, and the median pruritus numerical rating scale score was 7.0 (range, 0–10); for each of these measures, higher scores represent greater severity. Most registry patients (86.7%) had recently used topical corticosteroids or topical calcineurin inhibitors as treatment for AD . This registry cohort represents a population of Japanese patients with moderate to severe AD and provides an important resource for characterizing the disease burden and evaluating the safety and effectiveness of various AD treatments.

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Burden of atopic dermatitis in Japanese adults: Analysis of data from the 2013 National Health and Wellness Survey

Cited by 72 publications

References 41 publications

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

Burden of atopic dermatitis in Asia

Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS‐J): Baseline characteristics, treatment history and disease burden

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