Burden of cleft surgery—a 21-year follow-up of patients with cleft lip and palate

Martin, Serena; McBride, Michael; McGarry, Kevin; Hill, Chris

doi:10.1007/s00238-020-01633-z

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…It affects the face uni- or bilaterally, as well as the hard and soft palate ( Dixon et al, 2011 ). Extensive reconstructive surgery and dental treatment are often required until adulthood for the various forms of CLP ( Acum et al, 2020 ; Martin et al, 2020 ). After surgery, CLP patients may still experience difficulties with speaking and hearing, leading to psychosocial problems ( Martin et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Extensive reconstructive surgery and dental treatment are often required until adulthood for the various forms of CLP ( Acum et al, 2020 ; Martin et al, 2020 ). After surgery, CLP patients may still experience difficulties with speaking and hearing, leading to psychosocial problems ( Martin et al, 2020 ). About 30% of CLP cases arise as part of a syndrome caused by a single genetic mutation.…”

Section: Introductionmentioning

confidence: 99%

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Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors

Raterman

Metz

Wagener

et al. 2020

Front. Cell Dev. Biol.

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The zebrafish is an appealing model organism for investigating the genetic (G) and environmental (E) factors, as well as their interactions (GxE), which contribute to craniofacial malformations. Here, we review zebrafish studies on environmental factors involved in the etiology of craniofacial malformations in humans including maternal smoking, alcohol consumption, nutrition and drug use. As an example, we focus on the (cleft) palate, for which the zebrafish ethmoid plate is a good model. This review highlights the importance of investigating ExE interactions and discusses the variable effects of exposure to environmental factors on craniofacial development depending on dosage, exposure time and developmental stage. Zebrafish also promise to be a good tool to study novel craniofacial teratogens and toxin mixtures. Lastly, we discuss the handful of studies on gene–alcohol interactions using mutant sensitivity screens and reverse genetic techniques. We expect that studies addressing complex interactions (ExE and GxE) in craniofacial malformations will increase in the coming years. These are likely to uncover currently unknown mechanisms with implications for the prevention of craniofacial malformations. The zebrafish appears to be an excellent complementary model with high translational value to study these complex interactions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors

Raterman

Metz

Wagener

et al. 2020

Front. Cell Dev. Biol.

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“…Patients with cleft lip and palate need to undergo multiple types of treatment starting from early age until adulthood, which impacts their quality of life. 1,2 Cheiloplasty with primary rhinoplasty (primary correction) is necessary to improve function and aesthetics.…”

Section: Introductionmentioning

confidence: 99%

Nasolabial morphological changes in patients with unilateral cleft lip and palate using a Korat‐modified nasoalveolar moulding appliance with primary correction

Nirunrungrueng,

Virarat,

Techalertpaisarn

et al. 2024

Orthod Craniofacial Res

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ObjectiveThe objective of this study is to measure the morphological changes of the nose and lip in patients with unilateral cleft lip and palate before and after cheiloplasty with primary rhinoplasty (primary correction) in conjunction with Korat‐NAM usage.DesignLongitudinal cohort study.SettingCleft Center Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand.SubjectsTwenty‐six patients with unilateral cleft lip and palate.InterventionsControl group: only active obturator before primary correction. Experimental group: an active obturator and Korat‐NAM I before primary correction. A customized endotracheal tube was retained in the nostril for 3 weeks before switching to Korat‐NAM II for 1 year.Main Outcome MeasuresSix measurements comprising nostril rim length, nostril height, nostril sill width, columella angle, vertical lip height, and horizontal lip length were measured from the patients' photographs. All measurements, except the columella angle, were reported as the cleft side/non‐cleft side value ratio. Measurements were taken at the initial appointment, immediately before, 3 weeks after, and 1 year after primary correction.ResultsNostril rim length ratio, nostril height ratio, nostril sill width ratio, columella angle on the cleft side, and vertical lip height ratio were improved using Korat‐NAM before and 3 weeks after primary correction. Nostril rim length and height ratios were significantly better than the control group.ConclusionsKorat‐NAM improved nose and lip morphology before primary correction. An overcorrection improved the nose and lip morphology on the cleft side. The nostril rim length and vertical lip height on the cleft side also improved with Korat‐NAM II 1 year after primary correction.

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“…These conditions cause the affected individuals to face some difficulties in feeding, speech, hearing, and dental problems (Leslie & Marazita, 2013). Additionally, the patients also encountered some psychological problems and financial burdens of the treatment process (Al-Namankany & Alhubaishi, 2018; Martin et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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2023

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Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are the most common orofacial deformities observed in humans where almost 1 in 700 to 1 in 2,000 babies born each year are affected worldwide. This condition occurs when the specific and independently derived facial primordial fails to fuse together, hence forming the cleft of the lip and palate or the palate alone. These orofacial abnormalities can be divided into syndromic and non-syndromic where the deformities are either associated with other disorders or present on their own, respectively. It is important to understand every step in the lip and palate development during the embryonic stage to pinpoint the exact problem affecting the normal development of the human face. With current technologies, more genes are identified to be associated with and cause CLP and CP in humans. Therefore, this review aims to elaborate on the latest updates on the genetics of CLP and CP. Polymorphism in some of the genes has been associated with the incidence of these anomalies. Identification of these genes provides new knowledge on how these craniofacial abnormalities occur and hopefully will enable earlier treatment of these deformities to be implemented.

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Burden of cleft surgery—a 21-year follow-up of patients with cleft lip and palate

Cited by 8 publications

References 7 publications

Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors

Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors

Nasolabial morphological changes in patients with unilateral cleft lip and palate using a Korat‐modified nasoalveolar moulding appliance with primary correction

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