Burden of Coronary Artery Disease in Adults With Congenital Heart Disease and Its Relation to Congenital and Traditional Heart Risk Factors

Giannakoulas, George; Dimopoulos, Konstantinos; Engel, Reto; Göktekín, Ömer; Küçükdurmaz, Zekeriya; Vatankulu, Mehmet Akıf; Bédard, Élisabeth; Diller, Gerhard Paul; Papaphylactou, Maria; Francis, Dárrel P.; Mario, Carlo Di; Gatzoulis, Michael Α.

doi:10.1016/j.amjcard.2009.01.353

Cited by 151 publications

(96 citation statements)

References 30 publications

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“…57 In a study from the United Kingdom, dyslipidemia was present in 19% of all ACHD patients and in 15% and 10% with intermediate and complex lesions, respectively. 73 These data are from registries or single centers outside the United States and may not be accurately extrapolated to the US ACHD population, although available data suggest that at a minimum, the prevalence of dyslipidemia is likely similar to the general population.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

Congenital Heart Disease in the Older Adult

Bhatt¹,

Foster²,

Kuehl³

et al. 2015

Circulation

205

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Section: Diagnosis and Treatmentmentioning

confidence: 99%

Congenital Heart Disease in the Older Adult

Bhatt¹,

Foster²,

Kuehl³

et al. 2015

Circulation

205

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“…Previous studies showed that both hypertension and dyslipidemia are the most important risk factors for CAD (Sharrett et al 1994;Giannakoulas et al 2009). However, hypertension and dyslipidemia were not significantly associated with the presence of CAD in the multivariate analysis in our study.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Coronary Artery Disease Using Pulse Wave Velocity and Retinal Artery Lesions

Wang

Tang

Hua

2011

Tohoku J. Exp. Med.

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“…However, the prevalence of atherosclerotic coronary artery disease and its risk factors has not been quantified in large series of ACHD patients. Retrospective evaluations performed in small populations of ACHD patients undergoing cardiac catheterization have found no difference in the incidence of coronary artery disease compared with the general population 3. Estimation of the prevalence of atherosclerotic cardiovascular disease risk factors is a critical first step in determining the possible impact of coronary artery disease in the ACHD population and developing appropriate interventions.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome in Adults With Congenital Heart Disease

Deen

Krieger

Slee

et al. 2016

JAHA

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BackgroundMetabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndrome in ACHD patients is unknown.Methods and ResultsWe conducted a retrospective cohort study of ACHD patients at our center to quantify the prevalence of metabolic syndrome in an ACHD population. Using case‐control matching, we constructed a comparable control group from a population‐based sample of 150 104 adults. International Diabetes Federation criteria were used to define metabolic syndrome. We used logistic regression to compare the risk of metabolic syndrome across the resulting cohorts, which were composed of 448 ACHD patients and 448 controls matched by age and sex. Mean age of both groups was 32.4±11.3 years, and 51.3% were female. Obesity was present in 16.1% of the ACHD patients and 16.7% of the controls. Metabolic syndrome was more common in ACHD patients than in controls (15.0% versus 7.4%; odds ratio 1.82, 95% CI 1.25–2.65).ConclusionsOur data suggest that metabolic syndrome is more common among adults with congenital heart disease than in the general population. Thus, patients with congenital heart disease should be screened for metabolic syndrome and risk factors mitigated where possible to prevent atherosclerotic coronary artery disease. Preventive cardiology should be included during routine ACHD care.

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Burden of Coronary Artery Disease in Adults With Congenital Heart Disease and Its Relation to Congenital and Traditional Heart Risk Factors

Cited by 151 publications

References 30 publications

Congenital Heart Disease in the Older Adult

Congenital Heart Disease in the Older Adult

Prediction of Coronary Artery Disease Using Pulse Wave Velocity and Retinal Artery Lesions

Metabolic Syndrome in Adults With Congenital Heart Disease

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