Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

Ferrari, Alize J.; Charlson, Fiona J; Norman, Rosana; Patten, Scott B.; Freedman, Greg; Murray, Christopher J L; Vos, Theo; Whiteford, Harvey

doi:10.1371/journal.pmed.1001547

Cited by 2,668 publications

(1,851 citation statements)

References 34 publications

Supporting

Mentioning

1,743

Contrasting

Unclassified

Order By: Relevance

“…Depressive disorders were an important cause of years lived with disability in the 2010 Global Burden of Disease Study 35. Antidepressants are used to treat depression, anxiety, and various pain‐related conditions, and the utilization of these drugs has been increasing in the United Kingdom, United States, and elsewhere 27, 36, 37.…”

Section: Discussionmentioning

confidence: 99%

Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women

Parkin

Balkwill

Sweetland

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundSome investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and with use of antidepressant drugs. We explored these associations in a large prospective study of UK women.Methods and ResultsThe Million Women Study recruited 1.3 million women through the National Health Service Breast Screening Programme in England and Scotland. Three years after recruitment, women were sent a second questionnaire that enquired about depression and regular use of medications in the previous 4 weeks. The present analysis included those who responded and did not have prior VTE, cancer, or recent surgery. Follow‐up for VTE was through linkage to routinely collected National Health Service statistics. Cox regression analyses yielded adjusted hazard ratios and 95% CIs. A total of 734 092 women (mean age 59.9 years) were included in the analysis; 6.9% reported use of antidepressants, 2.7% reported use of other psychotropic drugs, and 1.8% reported being treated for depression or anxiety but not use of psychotropic drugs. During follow‐up for an average of 7.3 years, 3922 women were hospitalized for and/or died from VTE. Women who reported antidepressant use had a significantly higher risk of VTE than women who reported neither depression nor use of psychotropic drugs (hazard ratio, 1.39; 95% CI, 1.23–1.56). VTE risk was not significantly increased in women who reported being treated for depression or anxiety but no use of antidepressants or other psychotropic drugs (hazard ratio, 1.19; 95% CI, 0.95–1.49).ConclusionsUse of antidepressants is common in UK women and is associated with an increased risk of VTE.

show abstract

Section: Discussionmentioning

confidence: 99%

Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women

Parkin

Balkwill

Sweetland

et al. 2017

JAHA

View full text Add to dashboard Cite

show abstract

“…Here, weight norms are shown to be one that is influential. The most recent Global Burden of Disease study highlights the role of depressive disorders as the largest nonfatal contributor to the global burden of disease (Ferrari, Charlson, Norman, Patten, Freedman, Murray, … Whiteford, 2013); understanding why depressive risk is distributed in relation to social norms and arrangements is important to addressing it as a massive global public health concern. These findings also suggest that as overweight and obesity rates continue to rise in Korea (as they are predicted to), so should overall depressive risk for both genders (even if women are overall at greater risk).…”

Section: Discussionmentioning

confidence: 99%

Weight, gender, and depressive symptoms in South Korea

Brewis

Han

SturtzSreetharan

2017

American J Hum Biol

View full text Add to dashboard Cite

ObjectivesObesity consistently predicts depression risk, but the underlying mechanisms are poorly understood. Body concerns are proposed as key. South Korean society is characterized by extremely high levels of explicit weight stigma, possibly the highest globally. Using cross‐sectional Korean 2014 National Health Examination Survey (KNHANES) data, we test this proposition in a nationally representative sample of South Korean adults (N = 5,632).MethodsDepressive symptoms (outcome variable), was based on the PHQ‐9. Weight status (predictor variable), was based on direct measures of height and weight converted to BMI. Weight concern was self‐reported. Mediation analyses tested how weight concern mediated the influence of weight status on depressive symptoms for women and men.ResultsCurrent weight status influenced depressive symptoms in Korean adults, but not always directly. Concerns of being “fat” mediated that relationship. The effect increased significantly as BMI increased within “normal” and overweight/obese categories for women, and in overweight/obese categories for men. Even though women classified as underweight were significantly more depressed than those in other weight categories, there was no similar mediation effect related to weight concerns.ConclusionFor South Koreans, the stress of adhering to social norms and avoiding stigma related to body weight seems to explain the relationship between higher body weight and more depressive symptoms. Women are more vulnerable overall, but men are not immune. This study demonstrates that body concerns help explain why weight predicts depression, and more broadly supports the proposition that widespread weight‐related stigma is a potentially major, if unrecognized, driver of population‐level health disparities.

show abstract

“…It affects 4.7% of the global population and is the second leading cause of disability worldwide (Ferrari, Charlson, et al, 2013; Ferrari, Somerville, et al, 2013). MDD is currently treated by means of antidepressant medication, psychotherapy (often behavioral therapy) or a combination of these two.…”

Section: Introductionmentioning

confidence: 99%

A novel concurrent TMS‐fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

Vink

Mandija

Petrov

et al. 2018

Human Brain Mapping

103

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a severe mental disorder associated with high morbidity and mortality rates, which remains difficult to treat, as both resistance and recurrence rates are high. Repetitive transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC) provides a safe and effective treatment for selected patients with treatment‐resistant MDD. Little is known about the mechanisms of action of TMS provided to the left DLPFC in MDD and we can currently not predict who will respond to this type of treatment, precluding effective patient selection. In order to shed some light on the mechanism of action, we applied single pulse TMS to the left DLPFC in 10 healthy participants using a unique TMS‐fMRI set‐up, in which we could record the direct effects of TMS. Stimulation of the DLPFC triggered activity in a number of connected brain regions, including the subgenual anterior cingulate cortex (sgACC) in four out of nine participants. The sgACC is of particular interest, because normalization of activity in this region has been associated with relief of depressive symptoms in MDD patients. This is the first direct evidence that TMS pulses delivered to the DLPFC can propagate to the sgACC. The propagation of TMS‐induced activity from the DLPFC to sgACC may be an accurate biomarker for rTMS efficacy. Further research is required to determine whether this method can contribute to the selection of patients with treatment resistant MDD who will respond to rTMS treatment.

show abstract

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

Cited by 2,668 publications

References 34 publications

Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women

Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women

Weight, gender, and depressive symptoms in South Korea

A novel concurrent TMS‐fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

Contact Info

Product

Resources

About