Burden of digestive diseases in Portugal

Pinho, Inês; Santos, João Vasco; Dinis-Ribeiro, Mário

doi:10.1097/meg.0000000000000266

Cited by 20 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was expected, as alcohol consumption in Portugal is higher in males than females [24] and is most common between the ages of 25 and 54 years (80% of consumers) [25]. It is important to emphasise that ALD in males between 50 and 65 years of age has a mortality rate of 25-30/100,000, and so has the potential of having a severe impact on national productivity and economy [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Mortality Associated with Hepatobiliary Disease in Portugal between 2006 and 2012

Rocha

Marinho

Rodrigues

2017

GE Port J Gastroenterol

View full text Add to dashboard Cite

Introduction: Hepatobiliary disease is becoming a major public health problem, and recent data suggest that the burden of liver disease is higher than previously thought. Our aim was to quantify the mortality from hepatobiliary disease in Portugal and to compare this with the mortality related to other causes over a 7-year period (2006-2012). Materials and Methods: A statistical analysis of mortality data according to cause, sex, age, and region from the National Statistics Institute in Portugal was carried out. The data related to 14 causes of death, the most frequent of which were alcoholic liver disease (ALD) (International Classification of Diseases code K70), unspecified cirrhosis of liver (UCL) (K74.6), hepatocellular carcinoma (HCC) (C22.0), unspecified malignant neoplasm of liver (C22.9), and cholangiocarcinoma (C22.1). Results: Between 2006 and 2012, 18,279 deaths (24.5/100,000) from hepatobiliary disease were registered in Portugal, constituting the 8th leading cause of death. The main causes of death from hepatobiliary disease were ALD (7.1/100,000), UCL (5.5/100,000), and HCC (4.3/100,000), with a male predominance (72%). ALD was the main aetiology in younger age groups (40-65 years), while primary neoplasms of the liver and the intrahepatic bile ducts were predominant in the elderly (>80 years). The mortality related to HCC increased by 66% between 2006 and 2012. Conclusion: These data outline the burden of hepatobiliary disease in Portugal (8th cause of death) and highlight a potential impact on economic productivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Mortality Associated with Hepatobiliary Disease in Portugal between 2006 and 2012

Rocha

Marinho

Rodrigues

2017

GE Port J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Gastric cancer is a major health problem, being the 5th most common cancer and the 3rd cause of cancer-related death [ 1 ]. Portugal is a country with a high/moderate incidence of gastric cancer [ 2 ], and the burden of digestive diseases increased in the past decade [ 3 ].…”

Section: Introduction and Aimsmentioning

confidence: 99%

Long-Term Outcomes of Gastric Endoscopic Submucosal Dissection: Focus on Metachronous and Non-Curative Resection Management

Libânio

Pimentel‐Nunes

Afonso

et al. 2016

GE Port J Gastroenterol

View full text Add to dashboard Cite

Introduction: Endoscopic submucosal dissection (ESD) is an effective treatment for gastric superficial neoplasms and curative in 80-85% of the patients. The aims of this study were to identify risk factors for non-curative resection and metachronous development, and to evaluate patient management and outcome after non-curative resection. Methods: In this single-centre study, the outcome of consecutive patients submitted to gastric ESD was assessed during a minimum follow-up of 18 months. Univariate analysis and multivariate logistic regression were performed to identify risk factors. Results: ESD was performed in 194 lesions (164 patients) between 2005 and 2014. The median follow-up was 40 months. En bloc and complete resection rates were 95.3 and 93.8%, respectively. Male sex, larger tumor size, longer procedural time, and more advanced histology were associated with a non-curative resection (p < 0.05), but only carcinoma detected in biopsies before resection was identified as a significant risk factor on multivariate analysis. Metachronous lesions occurred in 18.4%, and the incidence rate was 4.7 lesions/100 person-years. Older age at diagnosis was identified as the only predictor of metachronous development in logistic regression. In the non-curative resection group, survival did not differ between patients allocated to surveillance and those submitted to gastrectomy; 75% of gastrectomy specimens showed no residual lesion. Conclusions: The risk factors identified for non-curative resection help to improve patient selection and patient information. Older patients had an increased risk for the development of metachronous lesions. In patients with non-curative resections, individualized patient management and surveillance seems to be an adequate option in selected cases.

show abstract

“…Despite its importance for the improvement of the quality of health care, there is only one report on the impact of IBD in Portugal ( 13 ) and a lack of data on the reoperation trends in Portuguese patients with IBD.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Bowel Disease Reoperation Rate Has Decreased Over Time If Corrected by Prevalence

Santiago

Magro²,

Correia

et al. 2020

Clinical and Translational Gastroenterology

View full text Add to dashboard Cite

INTRODUCTION: Despite the recent emergence of expensive biologic therapies, hospitalization and surgery remain important contributors for the overall costs of inflammatory bowel disease (IBD). In this study, we aimed to describe the burden of reoperations in patients with IBD by evaluating reoperation rates, charges, and risk factors over 16 years. METHODS: We performed a retrospective analysis of all hospital discharges, with focus on reoperations and with a primary diagnosis of IBD, in public hospitals between 2000 and 2015 in mainland Portugal from the Central Administration of the Health System's national registry. We collected data on patient, clinical, and healthcare charges. We used multivariate regressions to estimate the risk factors of IBD-related reoperations. RESULTS: We found that 5% of IBD-related hospitalizations were related to reoperations. The number of reoperations per year increased by approximately 200%. However, when corrected by the prevalence of the disease, IBD reoperation rates decreased. Mean IBD-related charges per hospitalization were 7,780 € in 2000 and 10,592 € in 2015, with total charges reaching 6.7 million euros by the end of the study. Risk factors for reoperation include urgent hospitalization, in patients with ulcerative colitis (odds ratio 1.94, 95% confidence interval 1.19–3.17, P = 0.008), and colic disease, in patients with Crohn's disease (odds ratio 1.57, 95% confidence interval 1.06–2.34, P = 0.025). DISCUSSION: To obtain an accurate scenario of reoperations among patients with IBD, it is mandatory to adjust the number of reoperations to the prevalence of the disease. Reoperation and its risk factors should be closely monitored to decrease the burden of IBD to the healthcare system.

show abstract

Burden of digestive diseases in Portugal

Cited by 20 publications

References 35 publications

Mortality Associated with Hepatobiliary Disease in Portugal between 2006 and 2012

Mortality Associated with Hepatobiliary Disease in Portugal between 2006 and 2012

Long-Term Outcomes of Gastric Endoscopic Submucosal Dissection: Focus on Metachronous and Non-Curative Resection Management

Inflammatory Bowel Disease Reoperation Rate Has Decreased Over Time If Corrected by Prevalence

Contact Info

Product

Resources

About