Burden of disease associated with asthma among the adult general population of five Middle Eastern countries: Results of the SNAPSHOT program

Mungan, Dilşad; Aydın, Ömür; Mahboub, Bassam; Albader, Mohammad; Tarraf, Hesham; Doble, Adam; Lahlou, Aaicha; Tariq, Luqman; Aziz, Fayaz; Hasnaoui, Abdelkader El

doi:10.1016/j.rmed.2018.03.030

Cited by 20 publications

(12 citation statements)

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“…28 Similarly, in the severe asthma group, mean scores were significantly lower in patients with uncontrolled asthma than in those with well-or partly controlled severe disease, the difference again being larger than the minimally important difference, consistent with other studies. 29 The relationships observed between headache frequency and impact or asthma control, on the one hand, and QoL on the other are consistent with those reported in other studies in these diseases [29][30][31][32][33][34] and provide further support for the internal validity of these PROMs for evaluating patients with severe migraine or severe asthma. In the case of severe migraine, the mobility, self-care and usual activity items of the EQ-5D were less impacted than in severe asthma, whereas the converse was true for the pain/ discomfort item.…”

Section: Discussionsupporting

confidence: 85%

<p>Patient-Reported Outcome in Two Chronic Diseases: A Comparison of Quality of Life and Response Profiles in Severe Migraine and Severe Asthma</p>

Lucas¹,

Aly²,

Touboul³

et al. 2020

PROM

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Introduction: Migraine and asthma are two frequent, disabling, chronic disorders with a major impact on patient well-being. The objectives of this study were to compare subjective well-being between patients with severe forms of migraine or asthma using a panel of PROs. Methods: Adult patients were recruited during routine consultations with chest physicians or neurologists. Patients with severe migraine (reporting headaches on ≥8 days/month and having failed ≥2 prophylactic treatments) and patients with severe asthma (according to the 2017 GINA definition: requiring Step 4 or 5 treatment or presenting uncontrolled symptoms) were eligible. Each patient completed the EuroQol Questionnaire (EQ-5D-5L), the Work Productivity and Activity Impairment Questionnaire (WPAI) and the Hospital Anxiety and Depression scale (HAD). Patients with severe migraine the 6-item Headache Impact Test (HIT-6) and those with severe asthma completed the Asthma Control Test (ACT). Results: 249 patients with severe migraine and 96 with severe asthma were enrolled. Mean EQ-5D-5L utility scores were significantly higher in the severe migraine group than in the severe asthma group (0.75±0.25 vs 0.68±0.26; p<0.01). Low EQ-5D-5L utility scores were associated with frequent (≥15 headache days/month) or disabling (HIT-6 score ≥60) headaches and with poor asthma control. Patients with severe migraine more frequently presented a HAD depression score ≥11 (23.0% in severe migraine; 7.5% in severe asthma; p<0.01), whereas those with severe asthma more frequently reported problems with mobility, self-care and usual activities. Absenteeism (percent worktime missed) was similar in both groups (severe migraine: 9.0%±19.1%; severe asthma: 13.8%±22.9%) but work impairment was higher in the severe migraine group (44.3% vs 28.4%; p<0.01). Conclusion: Quality of life, work activity and psychological distress are all deteriorated in both severe migraine and severe asthma. Different aspects are affected in the two diseases: a greater impact on psychological aspects in severe migraine and a greater impact on physical aspects in severe asthma.

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Section: Discussionsupporting

confidence: 85%

<p>Patient-Reported Outcome in Two Chronic Diseases: A Comparison of Quality of Life and Response Profiles in Severe Migraine and Severe Asthma</p>

Lucas¹,

Aly²,

Touboul³

et al. 2020

PROM

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“…Previous reports showed that the level of asthma control is still poor in the Middle East, with 44.2% of asthma patients reported uncontrolled asthma and these patients reported significantly lower utility values than controlled subjects. 12 , 13 Another survey of 200 asthmatic patients in the UAE revealed that a considerable proportion of the patients had poorly controlled asthma in the form of sudden severe attacks, troublesome symptoms, school and work absenteeism, and emergency room visits. 14 In the UAE, the economic burden of asthma was previously assessed in two studies, which demonstrated a high economic burden and lack of optimal disease management.…”

Section: Introductionmentioning

confidence: 99%

Direct and Indirect Costs of Asthma Burden in Abu Dhabi: A Retrospective Analysis of Insurance Claims Data from 2015 to 2018

Mazrouei¹,

Almannaei²,

Nur³

et al. 2021

CEOR

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Purpose Asthma causes a high economic burden on the health-care system. Previous research on the cost of asthma in Abu Dhabi was in 2011 and revealed high medical costs. This work aimed to estimate both direct and indirect costs of asthma with trend analysis over a period of four years. Patients and Methods All data on medical costs, work absenteeism, and mortality were collected from the e-claims system of the national health insurance database. Medical costs included medication use, emergency room (ER) visits, non-ER visits, outpatient care, and hospitalization from 2015 to 2018. Indirect costs in terms of work absenteeism were calculated by multiplying the average daily income per employer by the number of workdays missed due to sick leaves documented in the database in 2019. Results Over the years, the total medical costs increased from AED 161,843,698 in 2015 to AED 206,548,620 in 2018. The largest contribution was attributed to outpatient care, while hospitalization accounted for the smallest proportion of the total costs in 2018. Likewise, the mean annual per-patient cost in 2015 was AED 1119 and increased to AED 1162 in 2018. Indirect costs were estimated to be AED 27,482,319 resulting from 30,948 sick leaves in the year 2019 only. Conclusion Asthma is a cause for huge expenditure from the health-care system perspective in Abu Dhabi. It also has a large impact on society through work absenteeism. Costs of asthma management are increasing every year, which suggests a call-to-action to improve the disease management status using cost-effective strategies.

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“… 7 Findings from a large-scale study conducted in five countries in the region, including Saudi Arabia, revealed a rate of 44.2% for uncontrolled asthma (ACT≤19 points). 21 Because all citizens and residents in Saudi Arabia have access to health care facilities, a high rate of doctor-diagnosed asthma was expected for most self-reported asthma cases, which was indeed the case (83.3% of those who experienced asthma-ever reported that a doctor diagnosed their asthma). A similarly high percentage of doctor-diagnosed asthma (97%) was reported by a study from Canada that used the ISAAC questionnaire.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of asthma symptoms and associated risk factors among adults in Saudi Arabia: A national survey from Global Asthma Network Phase Ⅰ

Alomary

Madani

Althagafi

et al. 2022

World Allergy Organization Journal

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Purpose: Estimating the prevalence and severity of asthma symptoms with standardized methods of population-based surveys is a critical step in reducing asthma burden. However, no sufficient surveys have been conducted in most countries of the Middle East especially at the national level. In this survey, we applied sound measures to estimate the prevalence and severity of asthma symptoms and related risk factors in adults in Saudi Arabia.Patients and methods: In this national cross-sectional study, the prevalence and severity of asthma symptoms were estimated throughout the country. Overall, 7955 adult individuals were selected from 20 regions across Saudi Arabia through their children at schools using a multistage, stratified cluster-sampling technique. A validated questionnaire, including the core and environmental questions of the Global Asthma Network questionnaires, was applied from March 4 to April 25, 2019. In addition, multivariate logistic regression analysis was performed to investigate the independent relationships between current wheeze and related risk factors. Results:The overall prevalence of current wheeze (wheeze during the past 12 months) was 14.2%. Among persons with current wheeze, 38.1% were affected by severe asthma symptoms. Although a high percentage of those who had experienced asthma-ever reported that their asthma was diagnosed by doctors (83.3%), only 38.4% had a written plan for controlling their asthma. Women were more likely to develop current wheeze (adjusted odds ratio (aOR) 1.4; 95% CI: 1.1-1.7), while other statistically significant factors associated with current wheeze were jobs (aOR 11.8; 95% CI: 7.3-18.9), current exposure to moisture or damp spots (aOR 2.2; 95% CI: 1.5-3.4), heating the house when it is cold (aOR 1.7; 95% CI: 1.3-2.1), and ever using tobacco daily (aOR 2.7; 95% CI: 2.0-3.5).

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Burden of disease associated with asthma among the adult general population of five Middle Eastern countries: Results of the SNAPSHOT program

Abstract: Uncontrolled asthma imposes a significant burden in these Middle Eastern countries resulting in increased frequency of healthcare use, lower quality of life, and a higher impact on daily life compared to controlled asthma.

Cited by 20 publications

References 40 publications

<p>Patient-Reported Outcome in Two Chronic Diseases: A Comparison of Quality of Life and Response Profiles in Severe Migraine and Severe Asthma</p>

<p>Patient-Reported Outcome in Two Chronic Diseases: A Comparison of Quality of Life and Response Profiles in Severe Migraine and Severe Asthma</p>

Direct and Indirect Costs of Asthma Burden in Abu Dhabi: A Retrospective Analysis of Insurance Claims Data from 2015 to 2018

Prevalence of asthma symptoms and associated risk factors among adults in Saudi Arabia: A national survey from Global Asthma Network Phase Ⅰ

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