Burden of disease due to microcephaly associated with the Zika virus in Colombia

Mora-Salamanca, Andrés Felipe; Porras-Ramírez, Alexandra; Restrepo, Fernando De la Hoz

doi:10.1590/0102-311x00215319

Cited by 5 publications

(7 citation statements)

References 24 publications

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“…No specific studies for the burden of disease by CZS were found in the literature, but there were two studies on microcephaly associated with ZIKV 12 , 19 . More-Salamanca et al 19 , estimated 9.48 DALYs lost for each case of microcephaly associated with Zika virus in Colombia from 2015 to 2016, a value that is higher than that estimated in this study, which was 8.36 DALYs lost for each case from 2015 to 2020. When considering the period from 2015 to 2016, our analysis reveals that the estimated DALYs lost in Brazil are lower than the number of DALYs lost in Colombia.…”

Section: Discussionmentioning

confidence: 99%

“…Up to the time at which this study was carried out, the value of weight/burden of disability for CZS and the duration of the disease had not been described in the literature. For this reason, we used the value adopted by Mora-Salamanca et al 19 for calculating this metric when estimating the DALYs for ZIKV-associated microcephaly in Colombia, which is 0.16. This value was described by Salomon et al 20 and Alfaro-Murillo et al 12 and refers to the disability weight for severe intellectual disability.…”

Section: Methodsmentioning

confidence: 99%

“…This value was described by Salomon et al 20 and Alfaro-Murillo et al 12 and refers to the disability weight for severe intellectual disability. For the duration of the disease, we used the value of 35 years, which was proposed by Honeycutt et al 21 and also refers to the duration of intellectual disability (mental retardation) and was used in the calculation of DALYs in Colombia 19 .…”

Section: Methodsmentioning

confidence: 99%

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Disease burden of congenital Zika virus syndrome in Brazil and its association with socioeconomic data

de Amorin Vilharba,

Yamamura,

de Azevedo

et al. 2023

Sci Rep

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Zika virus (ZIKV) infection became a global public health concern, causing an epidemic in Latin America from 2015 to 2016, when a sudden increase in cases of microcephaly and other congenital anomalies was observed. In 2016, the Centers for Disease Control and Prevention and the World Health Organization defined congenital Zika-associated syndrome (CZS) as a set of congenital anomalies seen in children born to mothers with a history of gestational Zika fever, who have microcephaly as the most prevalent clinical sign. In order to describe the magnitude of CZS in Brazil, this study estimated the burden of disease due to CZS in Brazil using the disability-adjusted life years (DALY) indicator and other frequency measures, such as incidence and mortality rate, during the years 2015–2020. The association of these indicators with socioeconomic variables was also evaluated using Spearman's correlation coefficient. Choropleth maps were used to evaluate the spatial distribution of the indicators evaluated and the spatial autocorrelation was verified by the Bivariate Moran Local Index. From 2015 to 2020, 3,591 cases of CZS were confirmed in Brazil, with an incidence of 44.03 cases per 1000 live births, and a specific mortality of 12.35 deaths per 1000 live births. A global loss of 30,027.44 DALYs was estimated from 2015 to 2020. The Northeast region had the highest values for all health indicators assessed. Spatial correlation and autocorrelation analyses showed significant associations between health and socioeconomic indicators, such as per capita income, Gini index, illiteracy rate and basic sanitation. The study allowed us to have access to all reported cases of CZS, showing us the possible situation of the disease in Brazil; therefore, we believe that our results can help in the understanding of future studies.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Disease burden of congenital Zika virus syndrome in Brazil and its association with socioeconomic data

de Amorin Vilharba,

Yamamura,

de Azevedo

et al. 2023

Sci Rep

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“…In Colombia, a record number of microcephaly cases per epidemiological week occurred during the Zika virus epidemic (29,30). Nationally, it was estimated that between 10 173.16 and 10 860.57 disability-adjusted life years (DALYs) were lost due to microcephaly caused by Zika-virus (31).…”

Section: Zika Virusmentioning

confidence: 99%

Effects of public health emergencies of international concern on disease control: a systematic review

Araújo

Castro

Ávila

et al. 2023

Revista Panamericana De Salud Pública

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Objectives. To assess the accumulated knowledge of the effects of public health emergencies of international concern on disease control and local health systems, and contribute to a better understanding of their effects on health programs and systems. Methods. This was a systematic review of published and gray literature (in English, Portuguese, or Spanish). Electronic databases (BVS/LILACS, PubMed, and SciELO) and Google Scholar were searched. Search terms were: COVID-19 OR H1N1 OR Ebola OR Zika OR poliomyelitis AND (outbreaks OR epidemics) AND (public health systems OR public health surveillance). Results. A total of 3 508 studies were retrieved, of which 31 met the inclusion criteria. The studies addressed the effects of the emergencies on: communicable diseases notification systems; malaria, HIV/AIDS, tuberculosis, poliomyelitis, and malaria surveillance, control, and treatment; microcephaly; dengue; and vaccinations. The populations affected by the emergencies experienced reduced health services, which included fewer health visits, failures in the diagnostic chain, decrease in vaccination, and increased incidence or underreporting of notifiable diseases. Conclusions. Socioeconomic inequity is a determinant of the effects of public health emergencies of international concern within affected populations. The diversion of resources and attention from health authorities disproportionately affects vulnerable populations and can lead, over time, to a weakening of health systems. The analysis of the effects of public health emergencies is important for the development of new protocols that can better respond to future crises.

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“…El SGB es una entidad importante para el obstetra ya que el embarazo puede estar asociado a su aparición, además de estar asociado al virus del zika, infección viral que afectó a nuestra región en una epidemia en 2015 y 2016 17 , con especial repercusión en la salud perinatal 18 . Por tanto, el obstetra debe pensar en esta entidad y sus diferentes variantes que incluyen el SMF, ya que su manejo en la gestante puede requerir un equipo interdisciplinario.…”

Section: Introductionunclassified

Síndrome de Miller Fisher tratado con plasmaféresis durante el embarazo: reporte de un caso y revisión de la literatura

Ángel-Páez

Hurtado-Bugna

Aragón-Mendoza

et al. 2021

Rev. Colomb. Obstet. Ginecol.

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Objetivo: reportar el caso de una paciente gestante con síndrome de Guillain-Barré (SGB) presentado en la variante denominada síndrome de Miller Fisher (SMF), y realizar una revisión en torno al diagnóstico, tratamiento y pronóstico de esta variedad de SGB durante la gestación. Materiales y métodos: se presenta el caso de una gestante de 27 semanas con síndrome de Miller Fisher, quien fue tratada con plasmaféresis en un hospital general de referencia, con evolución satisfactoria a los 15 días y continuación normal del embarazo, parto a las 38 semanas con recién nacido sano. Se realizó una búsqueda bibliográfica en bases de datos electrónicas: Medline vía PubMed, Lilacs, SciELO, ScienceDirect, Ovid, con los términos “Embarazo”, “Síndrome de Miller Fisher”, “Síndrome de Guillain-Barré”. Se incluyeron cohortes, series y reportes de casos de mujeres gestantes con síndrome de Miller Fisher; se extrajo información sobre los métodos diagnósticos, el tratamiento utilizado y el pronóstico materno y perinatal. La búsqueda se hizo en junio de 2020, sin restricción por fecha, pero sí por tipo de idioma (español e inglés). Resultados: se identificaron 423 títulos, tres estudios cumplieron los criterios de inclusión, los tres correspondieron a reportes de caso. Todos los casos mostraron seropositividad para antigangliósidos GQ1b positivos; en ningún caso hubo alteración imagenológica. Dos pacientes recibieron inmunoglobulina intravenosa y la tercera paciente se dejó en observación. Hasta el momento no se documentan complicaciones obstétricas. Conclusión: existen pocos casos reportados de SMF durante la gestación, el diagnóstico se basa en el examen clínico; el tratamiento con inmunoglobulina IV representa la alternativa utilizada con mayor frecuencia. En el caso presentado se utilizó la plasmaféresis. Se desconoce el impacto de la variedad del síndrome de Miller Fisher sobre el curso normal de la gestación y sobre los resultados perinatales a largo plazo. Se requieren más estudios que aborden el diagnóstico, el tratamiento y el pronóstico de esta entidad.

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Burden of disease due to microcephaly associated with the Zika virus in Colombia

Cited by 5 publications

References 24 publications

Disease burden of congenital Zika virus syndrome in Brazil and its association with socioeconomic data

Disease burden of congenital Zika virus syndrome in Brazil and its association with socioeconomic data

Effects of public health emergencies of international concern on disease control: a systematic review

Síndrome de Miller Fisher tratado con plasmaféresis durante el embarazo: reporte de un caso y revisión de la literatura

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