Burden of epilepsy in Latin America and The Caribbean: a trend analysis of the Global Burden of Disease Study 1990 – 2019

Pacheco‐Barrios, Kevin; Navarro‐Flores, Alba; Cardenas-Rojas, Alejandra; Melo, Paulo S. de; Uygur-Kucukseymen, Elif; Alva-Díaz, Carlos; Fregni, Felipe; Burneo, Jorge G.

doi:10.1016/j.lana.2021.100140

Cited by 11 publications

(16 citation statements)

References 57 publications

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“… 19 Nevertheless, comprehensive burden assessments at the regional level in LAC remain scarce. 20 To the best of our knowledge, this is the first assessment of the stroke burden in LAC. We organized a hierarchy of stroke risk factors according to country and stroke subtype.…”

Section: Discussionmentioning

confidence: 94%

“…Standardized evaluations of the burden of neuropsychiatric diseases at regional levels are scarce. 20 , 57 , 58 In addition to the global stroke estimation, 2 estimations for Europe, Mexico, Brazil, and China have been updated. 59 , 60 , 61 , 62 In Europe, the age‐standardized DALY rate was 1340 per 100 000 habitants, 62 which was slightly higher than our estimate (1184.7) but lower than the global estimate (1768.1).…”

Section: Discussionmentioning

confidence: 99%

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Burden of Stroke and Population‐Attributable Fractions of Risk Factors in Latin America and the Caribbean

Pacheco‐Barrios

Giannoni‐Luza

Navarro‐Flores³

et al. 2022

JAHA

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Background Stroke burden characterization studies in low‐ and middle‐income countries are scarce. We estimated the burden of stroke and its risk factors in Latin America and the Caribbean (LAC). Methods and Results We extracted GBD (Global Burden of Disease) study 2019 data on overall stroke and 3 subtypes (ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage) for 20 LAC countries. We estimated absolute and age‐standardized rates of disability‐adjusted life years, years of life lost, years lived with disability, and deaths. The population‐attributable fractions of 17 risk factors were estimated. All analyses were performed at regional and national levels by stroke subtype, sex, and age subgroups. In 2019, the LAC region had the fourth largest stroke burden worldwide (6.8 million disability‐adjusted life years), predominantly attributable to premature deaths (89.5% of disability‐adjusted life years). Intracerebral hemorrhage was the primary cause of the overall stroke burden (42% of disability‐adjusted life years), but ischemic stroke was the leading cause of disability (69% of total years lived with disability). Haiti and Honduras had the highest age‐standardized rates. Older adults and men had the largest burdens, although women had the highest rate of disability. Socioeconomic development level did not influence the burden. The major risk factor clusters were metabolic (high systolic blood pressure [population‐attributable fraction=53%] and high body mass index [population‐attributable fraction=37%]), which were more influential in hemorrhagic events, women, and older adults. Household air pollution was an important risk factor in low‐income countries in LAC. Conclusions The stroke burden and stroke‐related mortality in LAC are higher than the worldwide averages. However, stroke is a highly preventable disease in this region. Up to 90% of the burden could be reduced by targeting 2 modifiable factors: blood pressure and body mass index. Further research and implementation of primary and secondary prevention interventions are needed, as well as integrated national stroke care programs for acute, subacute, and rehabilitation management in LAC.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Burden of Stroke and Population‐Attributable Fractions of Risk Factors in Latin America and the Caribbean

Pacheco‐Barrios

Giannoni‐Luza

Navarro‐Flores³

et al. 2022

JAHA

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“…In rural areas of Latin America there are difficulties in children's learning. In this way they obtain a low level in their subjects, as they do not have any learning method [4].By the end of 2021, students in Latin America will be affected by the COVID-19 pandemic, making a rapid shift from face-to-face to digital learning [5]. Brazil has 55 million people living in extreme poverty and has pre-school boys with illiteracy problems [6].…”

Section: Introductionmentioning

confidence: 99%

Designing a Mobile Application using Augmented Reality: The Case of Children with Learning Disabilities

Lazo-Amado¹,

Cueva-Ruiz²

2022

IJACSA

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The learning disorder has several difficulties to learn correctly; in many cases they have more stress because they do not understand the subjects proposed by the teacher. The aim of the research is to propose an innovative plan to design a mobile application for the treatment of learning disabilities using augmented reality in primary education. In this way, we used a methodology called Design Thinking that has five phases, empathize, define, devise, prototype and testing, which facilitates us in identifying the problems for itself to have solutions to these problems. For the prototype we used tools such as Marvel App, which is responsible for the layout of the mobile application. TinkerCad allows us to design the 3D model of the educational games and finally App Augmented Class to create the augmented reality model. The results obtained were through a survey about the prototype; identifying the acceptance about the prototype by parents for the usefulness of this idea for their children with learning disabilities, with 76% that the prototype is ideal for children. In addition, the prototype was validated by five experts, resulting in 85.4% acceptance. As a conclusion of the research is the achievement of a good design for a solution to the problems of children with learning disabilities to have a better understanding and to be free from stress.

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confidence: 99%

“…Epilepsy affects people of all ages, with a similar prevalence among men and women living in LAC (410 vs. 413 per 100,000 population, respectively).In 2019, a total of 1,375,066.9 disability-adjusted life years (DALYs) in LAC countries were attributed to epilepsy, with men being more affected. Three potential reasons may explain higher DALYs in men with epilepsy (MWE): 1) steroid hormones-adrenal corticosteroids and androgenic steroids-may increase seizure sensibility; however their molecular mechanisms are unclear 2) more epilepsy cases associated with exposure to potential injury triggers such as alcohol consumption, occupational or traffic accidents, and 3) higher incidence of Sudden Unexpected Death in Epilepsy (SUDEP) in males, particularly in the context of alcohol use [1].Depression and anxiety are important comorbidities associated with epilepsy [2]. These mental health issues can significantly impact the overall wellbeing of people with epilepsy and affect both genders.…”

mentioning

confidence: 99%

Re-Thinking Subjective Wellbeing of Latin-American and Caribbean Men With Epilepsy: Beyond Sexual Dysfunctions Issues

Nascimento¹,

Andrade-Valença²

2023

Int J Public Health

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The IJPH series "Young Researcher Editorial" is a training project of the Swiss School of Public Health.Epilepsy is a common neurological disease that affects the quality of life of approximately 6.3 million people in Latin America and the Caribbean (LAC) [1]. It is characterized by an enduring tendency to experience epileptic seizures and the neurobiological, cognitive, and psychosocial consequences of these seizures. Epilepsy affects people of all ages, with a similar prevalence among men and women living in LAC (410 vs. 413 per 100,000 population, respectively).In 2019, a total of 1,375,066.9 disability-adjusted life years (DALYs) in LAC countries were attributed to epilepsy, with men being more affected. Three potential reasons may explain higher DALYs in men with epilepsy (MWE): 1) steroid hormones-adrenal corticosteroids and androgenic steroids-may increase seizure sensibility; however their molecular mechanisms are unclear 2) more epilepsy cases associated with exposure to potential injury triggers such as alcohol consumption, occupational or traffic accidents, and 3) higher incidence of Sudden Unexpected Death in Epilepsy (SUDEP) in males, particularly in the context of alcohol use [1].Depression and anxiety are important comorbidities associated with epilepsy [2]. These mental health issues can significantly impact the overall wellbeing of people with epilepsy and affect both genders. Mental disease occurrence is exacerbated by social factors such as stigma and discrimination, especially for MWE. In addition, their diagnosis and treatment are often neglected.In general, health promotion interventions and policies that aim to promote gender equity tend to focus on improving the health of children and women, while men's health issues are stigmatized and tend to be ignored [3]. This tendency is also observed in epileptology, the study and treatment of epilepsy. Despite MWE experiencing gender-specific issues cited above, data on MWE tends to ignore the influence of psychosocial factors, focusing instead on the occurrence of sexual dysfunction (SD) [4]. In fact, MWE report sexual problems more often than healthy men. The higher occurrence of SD among MWE may be due to epilepsy, the use of anti-seizure drugs, and mental health issues. However, MWE quality of life scores are influenced more by depression and anxiety occurrence than clinical issues such as seizure control or SD [4].A better understanding of the inter-relation between mental health, wellbeing, and social factors for MWE health is necessary, but data about this question are scarce. The influence of sociocultural aspects on the behavior of chronically ill men has been evaluated in other clinical contexts, such as prostate cancer or psychiatric disorders. Evidence suggests that hegemonic social constructions of masculinity-including heterosexuality, assertiveness, self-control, physical strength, and emotional restraint-define an ideal man [5]. Chronically ill men who cannot attain the ideal of masculinity may experience subordination and marginali...

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Burden of epilepsy in Latin America and The Caribbean: a trend analysis of the Global Burden of Disease Study 1990 – 2019

Cited by 11 publications

References 57 publications

Burden of Stroke and Population‐Attributable Fractions of Risk Factors in Latin America and the Caribbean

Burden of Stroke and Population‐Attributable Fractions of Risk Factors in Latin America and the Caribbean

Designing a Mobile Application using Augmented Reality: The Case of Children with Learning Disabilities

Re-Thinking Subjective Wellbeing of Latin-American and Caribbean Men With Epilepsy: Beyond Sexual Dysfunctions Issues

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