Burden of influenza in the elderly: a narrative review

Conrad, Anne; Valour, Florent; Vanhems, Philippe

doi:10.1097/qco.0000000000000931

Cited by 10 publications

(3 citation statements)

References 81 publications

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“… 22 , 23 Such campaigns might lead to social and economic gains for the national health service, as the elderly are most susceptible to life-threatening consequences related to influenza. 24 , 25 …”

Section: Discussionmentioning

confidence: 99%

Influenza vaccination landscape in Italy: A comprehensive study through the OBVIOUS project lens

Capodici,

Montalti,

Soldà

et al. 2023

Human Vaccines & Immunotherapeutics

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Influenza annually claims an estimated 8,000 lives in Italy. Despite no-cost vaccinations for high-risk groups, hesitancy persists. This study aims to pinpoint social and behavioral vaccination determinants, forming strategies to bolster vaccine uptake. From April 11 to May 29, 2022, we surveyed a demographic-stratified sample of 10,000 Italian adults, employing the WHO’s Behavioral and Social Drivers of Vaccination (BesD) framework. Of those, 4,613 (46.1%) were eligible for the influenza vaccine and included in the analysis. Roughly a third remained unvaccinated and unwilling. Central Italy showed the highest resistance, with significant percentages of seniors and professionals like teachers, law enforcement, and healthcare workers expressing noncompliance. A lack of awareness of being in a target group correlated significantly with vaccine refusal or delayed acceptance. Other refusal factors included female gender, being aged 45–54, rural residency, absence of higher education, perceived vaccine unsafety, and having vaccine-opposed acquaintances. Thus, addressing these perceptions and enhancing awareness can potentially increase vaccination rates and lessen disease impact.

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Section: Discussionmentioning

confidence: 99%

Influenza vaccination landscape in Italy: A comprehensive study through the OBVIOUS project lens

Capodici,

Montalti,

Soldà

et al. 2023

Human Vaccines & Immunotherapeutics

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“…Streptococcus pneumoniae , influenza, and, more recently, COVID-19 infections, are leading causes of death and disability among the elderly. Vaccination against these diseases is a common practice for the elderly and is an integral part of the public health strategy for older adults [ 20 , 21 ]. Our group had a 39.2% uptake of pneumococcal vaccinations, a 45.6% uptake of influenza vaccinations, and a 95.7% uptake of at least one dose of a COVID-19 vaccination, according to the immunization data.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Meningococcal Carriage among Older Adults in Türkiye (MeninGOLD Study)

et al. 2023

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Introduction: While there is a significant amount of information about invasive meningococcal disease (IMD), meningococcal carriage, and meningococcal vaccines in children and adolescents, data in older adults are limited. Studies of meningococcal carriage and transmission modeling can be utilized to predict the spread of IMD and guide prevention and treatment strategies. Our study’s main objective was to assess the prevalece of Neisseria meningitidis (Nm) carriage, serogroup distribution, and associated risk factors among older adults in Türkiye. Methods: Nasopharyngeal samples were collected between December 2022 and January 2023 from a total of 329 older adults (65 years of age and above). The samples were tested via PCR for Nm, and a serogroup (A, B, C, Y, W, X, E, Z, H) analysis of the positive samples was performed. Results: In total, 329 adults over 65 years of age (150 females and 179 males; 69% were 65–75 years old and 31% were 75 years of age and older) were included in the study. Nm carriage was detected in 46 participants (13.9%), and the serogroup distribution was as follows: 2.4% MenY (n = 8), 1.8% MenB (n = 6), 0.2% MenW (n = 2), and 9.4% non-groupable (n = 31). Other serogroups were not detected. Between the meningococcal carriers and the non-carriers, there were no differences between previous vaccination histories (meningococcal, pneumococcal, influenza, and COVID-19), travel history for Hajj and/or Umrah, and the presence of chronic disease. Of the 16 cases positive for the serogroups Y, B, and W, 13 patients were between the ages of 65 and 74 and three patients were over 75 years old, and these three cases represented MenY. Conclusion: In our study, the percentage of meningococcal carriage was found to be 13.9%, the carriage rate for encapsulated strains was 4.8%, and the most common serogroup was MenY. Men Y was also the only serogroup detected in patients over 75 years of age. The MenY serogroup, which is one of the most important causes of IMD (especially in pneumonia cases) in people older than 65 years, was the most frequently carried serogroup in people over 65 years of age in our study. Adequate surveillance and/or a proper carriage study would help to define potential vaccination strategies for older adults.

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“…For comparison, each year influenza causes between 3 and 5 million severe cases, with 290,000–650,000 deaths globally, most of them occurring in older patients [ 13 ]. The influenza mortality rate in people aged > 70 years old is 16.4 per 100,000 people, compared to 1.9 in the general population [ 14 ]. Similarly to RSV, the population at higher risk of severe disease or complications due to influenza infection are children under 5 years of age, older people, individuals with chronic medical conditions (i.e.…”

Section: Epidemiology Virology and Immunopathologymentioning

confidence: 99%

Respiratory Syncytial Virus Infection in Older Adults: An Update

Alfano,

Bigoni,

Caggiano

et al. 2024

Drugs Aging

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Respiratory syncytial virus (RSV) infection represents one of the most common infections during childhood, with significant morbidity and mortality in newborns and in the early years of life. RSV is a common infection throughout all age groups, largely undetected and underestimated in adults, with a disproportionately high impact in older individuals. RSV infection has a wide range of clinical presentations, from asymptomatic conditions to acute pneumonia and severe life-threatening respiratory distress, including exacerbations of underlying chronic conditions. Overall, the incidence of RSV infections requiring medical attention increases with age, and it is highest among persons ≥ 70 years of age. As a consequence of a combination of an aging population, immunosenescence, and the related increased burden of comorbidities, high-income countries are at risk of developing RSV epidemics. The standard of care for RSV-infected patients remains supportive, including fluids, antipyretics, and oxygen support when needed. There is an urgent need for antivirals and preventive strategies in this population, particularly in individuals at higher risk of severe outcomes following RSV infection. In this review, we describe prevention and treatment strategies for RSV illnesses, with a deep focus on the novel data on vaccination that has become available (Arexvy, GSK, and Abrysvo, Pfizer) for older adults.

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Burden of influenza in the elderly: a narrative review

Cited by 10 publications

References 81 publications

Influenza vaccination landscape in Italy: A comprehensive study through the OBVIOUS project lens

Influenza vaccination landscape in Italy: A comprehensive study through the OBVIOUS project lens

Nasopharyngeal Meningococcal Carriage among Older Adults in Türkiye (MeninGOLD Study)

Respiratory Syncytial Virus Infection in Older Adults: An Update

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