Burden of Medication Overuse in Migraine: A Cross-sectional, Population-Based Study in Five European Countries Using the 2020 National Health and Wellness Survey (NHWS)

Dissing, Agnete Skovlund; Lee, Xin Ying; Østerberg, Ole; Hammer-Helmich, Lene

doi:10.1007/s40120-023-00545-x

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Utility of EQ-5D in migraine patients has been tested in different migraine studies showing higher impact in QoL compared to controls and correlation of EQ-5D scores with pain severity during attacks [15,16]. EQ-5D has also been used in epidemiological studies [17,18] and clinical trials with anti CGRP therapies [19][20][21][22].…”

Section: Health-related Quality Of Lifementioning

confidence: 99%

The state of art on the use of patient reported outcomes in migraine

Alpuente,

Torres-Ferrus,

Caronna

et al. 2024

Current Opinion in Neurology

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Purpose of review This review aims to explore the use of patient-reported outcome measures (PROMs) in migraine. Traditionally assessed through specific features, recent adoption of PROMs allows for a more objective and quantifiable evaluation. PROMs, which are standardized questionnaires collecting health information directly from a patients’ perspective, cover various aspects, including migraine specific aspects. The review focuses on delineating the applications and interpretation of commonly used PROMs in migraine research, with an emphasis on their integration in clinical care. Recent findings Generic and migraine-specific PROMs play a crucial role in clinical research, particularly in assessing health-related quality of life, disability, impact, and associated comorbidities. Some of these measures are strongly recommended to be used by the International Guidelines and are, in fact, mandated by the FDA for product labeling. Recently, there has been an expansion in the use of PROMs to assess migraine in diverse populations, in particular pediatric patients. However, the application of these measures in clinical care shows considerable heterogeneity, and some have not been validated specifically for migraine. The existing multitude of PROMs, coupled with ongoing development of new ones to better capture patient concerns, creates complexity in their research and clinical application. To address these challenges, it becomes imperative to streamline their use, focusing on those that are more validated and better aligned with the patients’ perspective including different populations’ needs. Summary The utilization of PROMs in evaluating migraine enables a more holistic assessment, helps quantify the impact of the disease facilitating change measurement, improves communication between healthcare providers and patients and, guides treatment decisions for improved outcomes. However, the increasing number of PROMs questionnaires, underscores the importance of validating these tools for migraine and, the dynamic nature of the disease makes it relevant to decide with whom, why and when these should be used.

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Section: Health-related Quality Of Lifementioning

confidence: 99%

The state of art on the use of patient reported outcomes in migraine

Alpuente,

Torres-Ferrus,

Caronna

et al. 2024

Current Opinion in Neurology

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Medication-overuse headache: description of patients and medications used before admission to specialized center

Starikova

2024

Rus. J. Pain

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Exploring the genetic causal relationship between physical activity and migraine in European population based on Mendelian randomization analysis

Wang,

Yang

2024

Front. Neurol.

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BackgroundPrevious studies have shown a connection between physical activity and migraines, but they don’t prove a cause-and-effect relationship due to potential biases in observational methods.MethodsUtilizing accelerometer-measured physical activity data from a cohort of 377,234 participants in the UK Biobank and information from 599,356 European migraine patients (including 48,975 cases and 550,381 controls) obtained from 24 cohorts, we performed a bidirectional Mendelian randomization analysis to investigate the genetic bidirectional causal relationship between accelerometer-measured physical activity and migraines.ResultsResearch findings indicated a slight negative genetic correlation between “average acceleration” physical activity (rg = −0.091, p = 0.011), overall physical activity (rg = −0.081, p = 0.017), and migraine. Nevertheless, no shared genetic components were observed between migraine and “fraction of accelerations > 425 mg” of physical activity (rg = −0.124, p = 0.076). The study results also demonstrated a lack of genetic bidirectional causality between accelerometer-measured physical activity and migraine (“average acceleration”, OR = 1.002, 95% CI 0.975–1.031, p = 0.855, “fraction of accelerations > 425 mg”, OR = 1.127, 95% CI 0.802–1.583, p = 0.488, overall physical activity, OR = 0.961, 95% CI 0.713–1.296, p = 0.799), and vice versa. Additionally, this lack of causal association persists even after adjusting for obesity (OR = 1.005, p = 0.578), education (OR = 1.019, p = 0.143), and depression (OR = 1.005, p = 0.847), either separately or simultaneously.ConclusionThe Mendelian randomization results based on genetic data do not provide support for a causal association between physical activity and migraine.

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Burden of Medication Overuse in Migraine: A Cross-sectional, Population-Based Study in Five European Countries Using the 2020 National Health and Wellness Survey (NHWS)

Cited by 3 publications

References 24 publications

The state of art on the use of patient reported outcomes in migraine

The state of art on the use of patient reported outcomes in migraine

Medication-overuse headache: description of patients and medications used before admission to specialized center

Exploring the genetic causal relationship between physical activity and migraine in European population based on Mendelian randomization analysis

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