Burden of multiple sclerosis on direct, indirect costs and quality of life: National US estimates

Campbell, Jonathan D.; Ghushchyan, Vahram; McQueen, R. Brett; Cahoon-Metzger, Sharon; Livingston, Terrie; Vollmer, Timothy; Corboy, John R.; Miravalle, Augusto; Schreiner, Teri; Porter, Victoria; Nair, Kavita V.

doi:10.1016/j.msard.2013.09.004

Cited by 115 publications

(93 citation statements)

References 39 publications

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“…Direct medical costs were estimated at $26,631 per MS patient for the year 2011, but may be much higher now, as considerably more expensive drugs have been developed and deployed widely over the past 5 years. 34 Indirect costs, consisting primarily of lost productivity, amount to an additional $21,854 per patient. 35 Using the midrange prevalence estimate of 500,000 patients, direct and indirect costs together total $24.2 billion annually in the United States.…”

Section: Multiple Sclerosismentioning

confidence: 99%

The burden of neurological disease in theUnitedStates: A summary report and call to action

Gooch

Pracht

Borenstein

2017

Annals of Neurology

331

219

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Section: Multiple Sclerosismentioning

confidence: 99%

The burden of neurological disease in theUnitedStates: A summary report and call to action

Gooch

Pracht

Borenstein

2017

Annals of Neurology

331

219

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“…Persons with MS often experience a diminished quality of life (QoL) due to the progression and symptoms of the illness (Campbell et al, 2014). There are several themes that have arisen in studies evaluating QoL among individuals with MS, including leaving or reducing paid employment (Irvine, Davidson, Hoy, & Lowe-Strong, 2009), changes in social relationships (Charmaz, 1983), and altered perceptions of self (Boeije, Duijnstee, Grypdonck, & Pool, 2002;Kralik, Koch, & Eastwood, 2003).…”

Section: Introductionmentioning

confidence: 99%

Social-emotional aspects of quality of life in multiple sclerosis

Lex

Weisenbach

Syed

et al. 2017

Psychology, Health & Medicine

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Multiple sclerosis (MS) is an inflammatory auto-immune disease of the central nervous system. It leads to many impairments including physical, cognitive, psychological, and social challenges. Our study examined gender and cultural associations with quality of life (QoL), personal characteristics, and benefits from having MS among those with MS. The study was conducted in Austria and the United States. The sample included 128 participants, 64 in each country, of whom 78 were women and 50 were men aged between 20 and 57 years. We used standard statistical tests, including analyses of covariance (ANCOVA) and partial correlations for the analysis of quantitative data. For the qualitative part of the survey we used semi-structured interviews, which we transcribed and coded to identify categories in the answers for qualitative analyses. Austrian participants with MS perceived a higher social-emotional QoL in comparison to American participants. American participants expressed a higher self-esteem in comparison to Austrian participants. Men reported a lower ability to express love than women. Independent of sex/gender and nationality, participants reported benefits through the disease, especially with regard to improved compassion, mindfulness, improved family relations and lifestyle gains. The qualitative interviews revealed additional gender differences for coping with the illness; and in experiences, expectations, and challenges related to MS. These insights can be used to develop targeted psychological and social support interventions aimed toward improving social-emotional QoL for persons with MS.

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“…1 The Department of Veterans Affairs (VA) health-care system treats approximately 16,000 veterans with MS each year. 2 MS is a chronic disease that results in an annual cost burden of $8500 to $54,000 per patient in the United States, much of it from complications secondary to MS. 3,4 Two recent studies have demonstrated an increased risk of infection-related hospitalizations and infectionrelated mortality in patients with MS compared with those without MS in Sweden and the United Kingdom. 5,6 The objective of this study was to examine the risk of hospitalization and death due to infections in patients with and without MS in a cohort of US veterans.…”

mentioning

confidence: 99%

Multiple Sclerosis and Risk of Infection-Related Hospitalization and Death in US Veterans

Nelson¹,

Xie²,

DuVall³

et al. 2015

International Journal of MS Care

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Background: This study estimated the risk of infection-related hospitalizations and death in patients with and without multiple sclerosis (MS). Methods: We identified adults with MS in the US Department of Veterans Affairs (VA) system between 1999 and 2010. Each veteran with MS was matched, on age and sex, with up to four veterans without MS. Multivariable Cox proportional hazards regression models were performed to assess the influence of MS on the development of serious and fatal infections. Results: The cohort included 7743 veterans with MS and 30,972 veterans without MS. Mean (SD) age was 53.8 (13.3) years, and 80.8% were male. The incidence per 1000 person-years of overall serious infections was 19.2 (95% confidence interval [CI], 17.6–20.8) for those with MS and 10.3 (95% CI, 9.8–10.9) for those without MS. Fatal infection incidence rates were 1.2 (95% CI, 0.8–1.7) for patients with MS and 0.5 (95% CI, 0.3–0.6) for patients without MS. Regression models showed that veterans with MS were at greater risk for overall serious (hazard ratio [HR] = 1.52, P < .01) and fatal (HR = 1.85, P = .03) infections and serious respiratory (HR = 1.31, P = .01), urinary tract (HR = 4.44, P < .01), and sepsis-related infections (HR = 2.56, P < .01). Conclusions: This study provides evidence that VA patients with MS are more likely than those without MS to be hospitalized and die of infection.

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Burden of multiple sclerosis on direct, indirect costs and quality of life: National US estimates

Cited by 115 publications

References 39 publications

The burden of neurological disease in theUnitedStates: A summary report and call to action

The burden of neurological disease in theUnitedStates: A summary report and call to action

Social-emotional aspects of quality of life in multiple sclerosis

Multiple Sclerosis and Risk of Infection-Related Hospitalization and Death in US Veterans

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