Burden of Osteoarthritis in China, 1990 to 2017: Findings from the Global Burden of Disease Study 2017

Long, Huibin; Zeng, Xinying; Liu, Qiang; Wang, Haidong; Vos, Theo; Hou, Yunfei; Lin, Chutong; Qiu, Yudian; Kai, Wang; Xing, Dan; Zhang, Yuqing; Lin, Jianhao; Zhou, Maigeng

doi:10.2139/ssrn.3478119

Cited by 9 publications

(10 citation statements)

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“…Several studies have documented the magnitude of subnational variation in the occurrence of OA and in related healthcare utilisation. The analysis of GBD data on OA for China by Long et al 12 showed persistent regional differences in the age-standardised prevalence of OA, with the highest rates found in the more rural south-western provinces, although the relative rank of OA as a cause for years lived with disability did not differ markedly from one region to another. Populations experiencing a greater burden of OA are typically also suffering a greater burden of other disabling non-communicable diseases.…”

Section: Describing the Distribution Of Osteoarthritis And Care In Po...mentioning

confidence: 99%

Osteoarthritis year in review 2020: epidemiology & therapy

Peat

Thomas

2021

Osteoarthritis and Cartilage

107

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Section: Describing the Distribution Of Osteoarthritis And Care In Po...mentioning

confidence: 99%

Osteoarthritis year in review 2020: epidemiology & therapy

Peat

Thomas

2021

Osteoarthritis and Cartilage

107

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“…Men are less likely to develop OA than women, making sex one of the risk factors associated with OA development [ 8 ]. Narrower femurs, thinner patellae, greater angles of quadriceps and differences in the size of tibial condyles make women’s knee anatomy different from men’s, leading to different kinematics, which influences female sex to be more likely to develop OA, ultimately leading to a higher prevalence of OA in women [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations

Primorac

Molnar

Rod

et al. 2020

Genes

285

176

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Being the most common musculoskeletal progressive condition, osteoarthritis is an interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) among adults 60 years of age or older is approximately 10% in men and 13% in women, making knee OA one of the leading causes of disability in elderly population. Today, we know that osteoarthritis is not a disease characterized by loss of cartilage due to mechanical loading only, but a condition that affects all of the tissues in the joint, causing detectable changes in tissue architecture, its metabolism and function. All of these changes are mediated by a complex and not yet fully researched interplay of proinflammatory and anti-inflammatory cytokines, chemokines, growth factors and adipokines, all of which can be measured in the serum, synovium and histological samples, potentially serving as biomarkers of disease stage and progression. Another key aspect of disease progression is the epigenome that regulates all the genetic expression through DNA methylation, histone modifications, and mRNA interference. A lot of work has been put into developing non-surgical treatment options to slow down the natural course of osteoarthritis to postpone, or maybe even replace extensive surgeries such as total knee arthroplasty. At the moment, biological treatments such as platelet-rich plasma, bone marrow mesenchymal stem cells and autologous microfragmented adipose tissue containing stromal vascular fraction are ordinarily used. Furthermore, the latter two mentioned cell-based treatment options seem to be the only methods so far that increase the quality of cartilage in osteoarthritis patients. Yet, in the future, gene therapy could potentially become an option for orthopedic patients. In the following review, we summarized all of the latest and most important research in basic sciences, pathogenesis, and non-operative treatment.

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“…This latter figure is highly relevant to the growing OA burden on health services and societies worldwide. Wu et al's 12 analysis of GBD data confirms this pattern in China but adds little to the previous analysis by Long et al 13 noted in the previous Year in Review 14 . Whilst comparative analyses of trends in incidence of OA between countries and regions is important, measuring incidence is notoriously difficult and there is still a dearth of estimates from comparable data sources in low-and middle-income countries on which to confidently base inferences.…”

Section: Osteoarthritis and Cartilagementioning

confidence: 80%