Burden of paediatric rotavirus gastroenteritis and potential benefits of a universal rotavirus vaccination programme with RotaTeq® in France

Huet, Frédéric; Largeron, Nathalie; Trichard, M; Miadi-Fargier, H; Jasso-Mosqueda, Guillermo

doi:10.1016/j.vaccine.2007.06.015

Cited by 39 publications

(15 citation statements)

References 24 publications

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“…Our calculation of the number of avoidable cases confirmed that universal vaccination would reduce the impact of RV infection on ED admissions, hospitalisations and admissions to the SO unit; similar finding have been reported by other authors [26] [27]. These results are confirmed by recent data on surveillance in the USA, where the introduction of RV vaccination into the paediatric immunization schedule has reduced the burden of RV gastroenteritis [28].…”

Section: Discussionsupporting

confidence: 89%

Burden of rotavirus infections in Liguria, northern Italy: hospitalisations and potential savings by vaccination

Panatto

Amicizia

Giacchino

et al. 2011

Eur J Clin Microbiol Infect Dis

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Purpose We evaluated the rates of gastroenteritis admissions to the emergency department and of rotavirusrelated hospitalisations in children ≤5 years in 2006 at an Italian paediatric hospital; we calculated the number of rotavirus cases avoidable through the universal vaccination of children.Methods Epidemiological data were extracted from the Data Elaboration Centre. To calculate the hospitalisation rate due to rotavirus, the virus was sought in the faeces of children hospitalised for acute gastroenteritis by means of rapid immunochromatographic assay.Results Emergency department admissions due to gastroenteritis numbered 2396 (11.58% of total admissions).Of these, 276 children (11.52%) were examined and then sent home; 1286 (53.67%) were kept in short observation and 776 (32.38%) were hospitalised. In 27.83% of hospitalised cases, the rotavirus test proved positive. The RV hospitalization rate was 55 per 10000 children ≤5 years in Genoa in 2006. In 85.6% of hospitalised patients with community-acquired rotavirus infection, the disease was severe. ConclusionsThe number of avoidable cases confirmed that the vaccination of children ≤1 year of age could reduce the burden of rotavirus infection, especially with regard to hospitalisation (45 per 10000 children ≤5 years) and admissions to short observation (85 per 10000), generating benefits for Italian healthcare system.

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Section: Discussionsupporting

confidence: 89%

Burden of rotavirus infections in Liguria, northern Italy: hospitalisations and potential savings by vaccination

Panatto

Amicizia

Giacchino

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…Model outcomes in this study regarding the percent reduction of rotavirus hospitalizations after universal rotavirus immunization (a 74% reduction) also agreed with the data obtained by the studies adopting decision tree models to cost-effectiveness analyses conducted in developing and industrialized countries (a median of 76% with a range between 51% and 100%) [Fischer et al, 2005;Podewils et al, 2005;Huet et al, 2007;Newall et al, 2007;Widdowson et al, 2007;Goossens et al, 2008;Melliez et al, 2008;Valencia-Mendoza et al, 2008;Zomer et al, 2008;Panatto et al, 2009;Wu et al, 2009].…”

Section: Discussionsupporting

confidence: 84%

“…This incidence looked much higher compared with an incidence of 3.8 and 4.9 per 1,000 child-years observed in two other sentinel hospitals in another region of Japan [Kamiya et al, 2009]. The incidence of rotavirus hospitalizations in Japan (a median of 9.0 in the four reports from Japan) was similar to the median incidence of 7.8 per 1,000 children less than 5 years of age (range: 2.5-20.0) in 11 developed countries [Nakagomi et al, 2005[Nakagomi et al, , 2009Nelson et al, 2005;Podewils et al, 2005;Lu et al, 2006;Chen et al, 2007;Fischer et al, 2007;Huet et al, 2007;Jit and Edmunds, 2007;Newall et al, 2007;Widdowson et al, 2007;Goossens et al, 2008;Luquero et al, 2008;Melliez et al, 2008;Kamiya et al, 2009;Martin et al, 2009;Panatto et al, 2009;Wu et al, 2009].…”

Section: Discussionsupporting

confidence: 56%

Modeling seasonal variation in rotavirus hospitalizations for use in evaluating the effect of rotavirus vaccine

Sato

Nakagomi

Naghipour

et al. 2010

Journal of Medical Virology

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Every year rotavirus epidemic repeats in cooler months of the year in temperate countries, but the size of the epidemic may often vary. Such seasonal variation needs to be considered when the effect of rotavirus vaccine is predicted before vaccine introduction or it is evaluated after vaccine introduction. A computer program based on a stochastic decision tree model was developed to produce stochastic variation, which was used as a proxy for seasonal variation, in the number of rotavirus hospitalizations. When the model was applied to a hypothetical community with a birth cohort of 1,000 children in Japan, it predicted the occurrence of up to 29% of stochastic variation from the average number of rotavirus hospitalizations. Then, the model was applied for use in evaluating the effect of rotavirus vaccine in two different scenarios regarding vaccine use in the community: a scenario where rotavirus vaccine was introduced only into the private sector, and another where it was incorporated into the universal immunization program. In the former scenario, an average of 23% reduction in the number of rotavirus hospitalizations was predicted, but this level of reduction would be obscured due to seasonal variation. In the latter scenario, an average of 74% reduction was predicted, which would be beyond seasonal variation. This model will be useful to inform stakeholders and policymakers how vaccine introduction will change the burden of rotavirus disease under different scenarios of vaccine implementation.

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“…Authors often derived the incidence of ED visits based on a proportion of ED visits assumed to be attributable to RV, or referred to previous cost-effectiveness studies published for the same country or a close country. The variability in yearly incidence of ED visits between countries was moderate, ranging from 0% for France, 14 to 2.65% for Belgium, 18 and the impact on results was small.…”

Section: Assumptions and Inputs Of Economic Evaluationsmentioning

confidence: 88%

“…Annual mortality rate was also found to be highly variable between developed and developing countries, with a low rate for developed countries (e.g., 0.0004% for France, 18 0.000246% for Finland 16 ), and a high rate for developing countries (e.g., 0.034% for Colombia, 49 0.05% for Peru 53 ). The mortality rate has a very high impact in developing countries, but more surprisingly, the impact is also important for developed countries.…”

Section: Assumptions and Inputs Of Economic Evaluationsmentioning

confidence: 98%

A critical literature review of health economic evaluations of rotavirus vaccination

Aballéa

Millier

Quilici

et al. 2013

Human Vaccines & Immunotherapeutics

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Burden of paediatric rotavirus gastroenteritis and potential benefits of a universal rotavirus vaccination programme with RotaTeq® in France

Cited by 39 publications

References 24 publications

Burden of rotavirus infections in Liguria, northern Italy: hospitalisations and potential savings by vaccination

Burden of rotavirus infections in Liguria, northern Italy: hospitalisations and potential savings by vaccination

Modeling seasonal variation in rotavirus hospitalizations for use in evaluating the effect of rotavirus vaccine

A critical literature review of health economic evaluations of rotavirus vaccination

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