Burden of serious fungal infections in Honduras

Higuita, Nelson Iván Agudelo; Bustillo, Diana Varela; Denning, David W.

doi:10.1111/myc.13432

Cited by 3 publications

(1 citation statement)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the purposes of this review, we are particularly interested in how HIV infection might affect diagnostic test accuracy, keeping in mind that the degree of immune suppression (and so diagnostic test performance) may vary amongst people with HIV (PWH). HIV status is particularly important given the high incidence of histoplasmosis in PWH in many countries [ 3 , 34 ].…”

Section: Performance Of Diagnostic Tests For People With Disseminated...mentioning

confidence: 99%

The Current and Future States of Diagnostic Tests for Histoplasmosis with a Focus on People with HIV and Disseminated Histoplasmosis

Villareal

Price

Pasqualotto

et al. 2023

JoF

View full text Add to dashboard Cite

Histoplasmosis is caused by Histoplasma capsulatum and, although endemic in large parts of the world, is often underrecognized in many locations. In addition to underrecognition, inadequate availability of diagnostic tests is a major contributor to poor outcomes in disseminated disease in people with HIV. For those with advanced HIV and disseminated disease, antibody testing is less useful. Culture and histopathology can be useful in this situation, but each has limitations, including variable sensitivity by site and, in the case of culture, the need for a biosafety level three laboratory and a long period of growth. Antigen testing has proven useful for disseminated histoplasmosis due to the excellent sensitivity of urine. Yet, turnaround is slower than ideal due to use in a limited number of centers. The development of lateral flow assays has the potential to make for true rapid point-of-care assays for histoplasmosis, but in order to meet that promise, the tests must be widely available and affordable.

show abstract

Section: Performance Of Diagnostic Tests For People With Disseminated...mentioning

confidence: 99%

The Current and Future States of Diagnostic Tests for Histoplasmosis with a Focus on People with HIV and Disseminated Histoplasmosis

Villareal

Price

Pasqualotto

et al. 2023

JoF

View full text Add to dashboard Cite

show abstract

Strengthening Fungal Infection Diagnosis and Treatment: An In-depth Analysis of Capabilities in Honduras

Ortiz,

Varela,

Fontecha

et al. 2024

Open Forum Infectious Diseases

View full text Add to dashboard Cite

Background Invasive fungal infections (IFI) are a major public health concern in low- and middle-income countries (LMICs) due to limited diagnostic and treatment resources, leading to high morbidity and mortality. Despite their significant global burden, IFI are under-recognized and under-diagnosed in LMICs. This study evaluates the diagnostic and therapeutic capacities for managing IFI in Honduras, a country with unique healthcare challenges. Methods From March to December 2023, a comprehensive survey was conducted across multiple healthcare centers in Honduras. The survey, reviewed for content and clarity by local medical institutions, targeted medical microbiologists and clinicians to assess various aspects of fungal disease diagnosis and treatment. Data collected included the availability and use of diagnostic tools and antifungal therapies, identifying gaps and limitations in current practices. Results The survey revealed that Candida spp. (97.4%) and Aspergillus spp. (35.9%) were the most concerning pathogens. Although microscopy and culture methods were available in most institutions, their application in suspected IFI cases was inconsistent, and antifungal susceptibility testing was rarely performed. Advanced diagnostic techniques, such as antigen detection, were available in only a few institutions, while antibody detection and PCR testing were entirely absent. All hospitals had access to at least one triazole antifungal, typically fluconazole, but there was a notable scarcity of more potent antifungals, including amphotericin B formulations and echinocandins. The limited use of available diagnostic tools and the restricted availability of essential antifungals were identified as major barriers to effective IFI management. Conclusions This study highlights significant gaps in the diagnostic and therapeutic capabilities for managing IFI in Honduras. The underutilization of basic diagnostic tools, the inaccessibility of advanced testing methods, and the limited availability of essential antifungal medications underscore the urgent need for capacity-building initiatives, infrastructure improvements, and policy reforms. Addressing these deficiencies is critical for enhancing the management of IFI in Honduras, with broader implications for similar LMIC settings. These findings can inform targeted interventions and resource allocation to improve outcomes for patients suffering from IFI.

show abstract

Частота Встречаемости Форм Онихомикоза И Нозологий Сопутствующих Заболеваний Кожи У Военнослужащих

Güliyeva

2023

Azerbaijan Medical Journal

View full text Add to dashboard Cite

Ayaq epidermofiti və rubromikozu qeydə alınan dəri mikozu olan pasiyentlərdə onixomikozun formaları, yanaşı dəri patologiyalarının rast gəlinməsi və nozoloji strukturu, göbələk infeksiyasından qaynaqlanan ağırlaşmalar və onların strukturunun müəyyənləşdirilməsi məqsədilə daxili qoşunların ayaq epidermofiti olan 125 nəfər və ayaq rubromikozu olan 125 nəfər (ümumilikdə 250 nəfər) dəri mikozlu olan hərbi qulluqçusu tədqiqata cəlb edilmişdir. Onixomikozun normotrofik və hipertrofik formalarının paylanması müəyyənləşdirildikdə ayaq dermofiti olan dəri mikozlu pasiyentlərdən 76,8±3,78%-də onixomikozun normotrofik forması qeydə alınmışdır. Ümumilikdə ayaq rubromikozu və ayaq epidermofiti olan, dəri mikozundan əziyyət çəkən pasiyentlərdən 16 nəfərdə göbələk infeksiyası mənşəli ikincili piodermit qeydə alınmışdır. İkincili infeksiyası olan pasiyentlərdən 25,0±10,8%-də allergik dermatit müşahidə edilmişdir. С целью определения форм онихомикоза у больных микозами кожи с эпидермофитами стоп и рубромикозами, частоты встречаемости и нозологической структуре сопутствующей кожной патологии, осложнений, вызванных грибковой инфекцией и их структуры обследовано 125 человек с эпидермофитами стоп и 125 человек с рубромикозами стоп. Всего в исследовании приняли участие 250 военнослужащих внутренних войск с микозами кожи. На этапе, когда определяли распределение нормотрофической и гипертрофической форм онихомикоза, нормотрофическая форма онихомикоза регистрировалась у 76,8±3,78% больных микозом кожи с дермофитиями ног. Всего вторичная пиодермия грибковой инфекции зарегистрирована у 16 больных микозом кожи с рубромикозом стопы и эпидермофитией стопы. Аллергический дерматит наблюдался у 25,0±10,8% больных с вторичной инфекцией. In order to determine the forms of onychomycosis in patients with skin mycosis accompanied by foot epidermophytosis and rubromycosis, the occurrence and nosological structure of concomitant skin pathologies, and the complications caused by fungal infections and their structure, a total of 250 military personnel from internal troops with skin mycosis were involved in the study. This included 125 people with foot epidermophytosis and 125 people with foot rubromycosis. During the phase where we determined the distribution of normotrophic and hypertrophic forms of onychomycosis, the normotrophic form was recorded in 76.8±3.78% of patients with skin mycosis and leg dermophytosis. In total, secondary pyoderma from fungal infection was recorded in 16 patients suffering from skin mycosis with foot rubromycosis and foot epidermophytosis. Allergic dermatitis was observed in 25.0±10.8% of patients with secondary infection.

show abstract

Burden of serious fungal infections in Honduras

Cited by 3 publications

References 68 publications

The Current and Future States of Diagnostic Tests for Histoplasmosis with a Focus on People with HIV and Disseminated Histoplasmosis

The Current and Future States of Diagnostic Tests for Histoplasmosis with a Focus on People with HIV and Disseminated Histoplasmosis

Strengthening Fungal Infection Diagnosis and Treatment: An In-depth Analysis of Capabilities in Honduras

Частота Встречаемости Форм Онихомикоза И Нозологий Сопутствующих Заболеваний Кожи У Военнослужащих

Contact Info

Product

Resources

About