Burden, Trends, and Inequalities of Heart Failure Globally, 1990 to 2019: A Secondary Analysis Based on the Global Burden of Disease 2019 Study

Abstract

Background Heart failure is a public health issue worldwide. However, no comprehensive study on the global burden of heart failure and its contributing causes has been reported. The present study aimed to quantify the burden, trends, and inequalities of heart failure globally. Methods and Results Heart failure data were extracted from the Global Burden of Diseases 2019 study. The number of cases, age‐standardized prevalence, and years lived with disability in different locations from 1990 to 2019 were presented and compared. Joinpoint regression analysis was performed to assess trends in heart failure from 1990 to 2019. In 2019, the global age‐standardized prevalence and years lived with disability rates for heart failure were 711.90 (95% uncertainty interval [UI], 591.15–858.29) and 63.92 (95% UI, 41.49–91.95) per 100 000 population, respectively. In general, the age‐standardized rate decreased globally at an average annual percentage change of 0.3% (95% UI, 0.2–0.3). However, the rate increased at an average annual percentage change of 0.6% (95% UI, 0.4–0.8) from 2017 to 2019. Several nations and territories demonstrated an increased trend from 1990 to 2019, especially in less‐developed countries. Ischemic heart disease and hypertensive heart disease accounted for the highest proportion of heart failure in 2019. Conclusions Heart failure remains a major health problem, with increased trends possible in the future. Efforts for prevention and control of heart failure should focus more on less‐developed regions. It is essential to prevent and treat primary diseases such as ischemic heart disease and hypertensive heart disease for the control of heart failure.

Advances in management of heart failure

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Injectable Peptide Hydrogels Loaded with Murine Embryonic Stem Cells Relieve Ischemia In Vivo after Myocardial Infarction

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“…Myocardial infarction (MI) affects 1−2% of the adult population, and the risk of MI increases with age. 5 Cardiac muscle ischemia due to MI as well as additional injury caused by reperfusion of the myocardium in the clinic (reperfusion injury) is a major cause of heart failure and associated with a high level of mortality. 6 Hence, a major challenge of cardiovascular regenerative medicine is the development of novel therapeutic strategies that facilitate the regeneration of normally functioning cardiac muscle in the diseased heart.…”

Impact of mental disorders on unplanned readmissions for congestive heart failure patients: a population‐level study

“…Congestive heart failure (CHF) is one of the major health issues in high‐income nations. In 2019, it was estimated that there were around 56.19 million cases globally, resulting in 5.05 million years lived with disability across the world 1 . In the United States, the cost of heart failure was estimated to be US$30.7 billion in 2012 and projected to rise to US$69.8 billion by 2030, with hospitalization being the major contributor 2 .…”