“…This secretion system has emerged as virulence factor that may take part in the pathogenic bacterial-host interactions or promote commensal or mutualistic relationships between bacteria and eukaryotes or to mediate cooperative or competitive interactions between bacteria (Jani & Cotter, 2010). For instance, in Gram-negative bacteria, it has been used for the purpose of interbacterial competition in Bcc member (Spiewak et al, 2019), and endure the innate immune response in host (Lennings, West & Schwarz, 2019). We also identified several regulatory genes that form the major requirement for a functional T6SS, such as structural proteins (VasH, VasK, VasF, VasA), effector protein (VgrG), and functional domains (chaperone ClpB, ImpA, ImpB, ImpC, ImpD, ImpF, ImpG, ImpH, ImpJ) in the pangolin Pf genome.…”