Burkholderia multivorans: A rare yet emerging cause of bacterial meningitis

Abstract

Burkholderia multivorans is a member of the Burkholderia cepacia complex. Although it is usually associated with infections in patients with cystic fibrosis, chronic granulomatous disease, and immunosuppression, central nervous infections are not commonly reported. Moreover, management of these infections is difficult due to multiple mechanisms of bacterial resistance to antimicrobial agents. We report a 55-year-old-man who developed Burkholderia multivorans meningitis after two episodes of central line-associated bloodstream infections. The patient was successfully treated with intravenous trimethoprim/sulfamethoxazole. Burkholderia multivorans is an emerging cause of meningitis with limited antibacterial treatment options. However, trimethoprim/sulfamethoxazole remains an effective agent with excellent penetration into the central nervous system. To our knowledge, this is the first case reported of Burkholderia cepacia complex meningitis identified to the species level as Burkholderia multivorans.

Pathogen Detection in RNA-Seq Data with Pathonoia

“…stabilis belongs, were able to infect human brain tissue and cause brain abscesses Hobson et al . (1995) and meningitis Peralta et al . (2018).…”

“…An FTD case study indicates that some patients may have (had) a B.stabilis infection in the brain. It was shown in literature that members of the Burkholderia cepacia complex, to which B.stabilis belongs, were able to infect human brain tissue and cause brain abscesses Hobson et al (1995) and meningitis Peralta et al (2018). Furthermore, Burkholderia pseudomallei, belonging to the same genus, are up-regulated in two independent, publicly available datasets concerning neurodegenerative diseases as shown in the Small RNA Expression Atlas Rahman et al (2019) platform (Suppl.…”

Burkholderia Cepacia: A Rare Cause of Bacterial Meningitis

“…Burkholderia cepacia is almost always a colonizing organism rather than an infecting organism, but it may be important when isolated from body fluids that are ordinarily sterile. 1 Burkholderia cepacia management is challenging due to its ability to overcome the action of multiple antimicrobials through various resistance mechanisms. Those mechanisms include the production of β-lactamases, carbapenemases, and antibacterial drug efflux pumps as well as the ability to decrease the number of membrane porins, modify bacterial lipopolysaccharide structure, and mutate antimicrobial binding targets.…”

“…Burkholderia cepacia is an opportunistic environmental pathogens that can be found in soil and water, primarily associated with causing infections in patients with cystic fibrosis, chronic granulomatous disease. 1…”

Potent modulation of the CepR quorum sensing receptor and virulence in a Burkholderia cepacia complex member using non-native lactone ligands

“…Members of the Burkholderia cepacia complex (Bcc) have emerged as multi-drug resistant opportunistic pathogens in human infections, including pulmonary infection associated with cystic fibrosis (CF) 1 and central nervous system infections 2 . The Bcc consists of more than 17 closely-related species that are mostly found in the environment and has grown to include not only plant, animal, and human pathogens, but also bioremediation and biocontrol strains.…”