Burkitt’s lymphoma associated with Helicobacter pylori

Abstract

The association between Helicobacter pylori infection and low grade mucosa-associated lymphoid tissue lymphoma is now widely accepted. In this report, we describe the concurrent development of Burkitt's lymphoma in the stomach of a 53-year-old male with perforated duodenal ulcer and positive H. pylori serology. The temporal relationship between these two events raises the possibility of a causal link between H. pylori infection and this lymphoproliferative disease. In describing this rare case of gastric Burkitt's lymphoma, we consider the evidence that supports this possibility.

Primary gastric Burkitt lymphoma in childhood: Associated with Helicobacter pylori?

“…The concurrent existence of gastric BL and H. pylori infection as in one of our patients has been previously described for a 53-year old male patient [27].…”

Disseminated Burkitt lymphoma presenting as massive gastrointestinal bleed

“…1 The 5-year survival rate for BL with secondary involvement in patients who receive prompt therapy ranges from 39% to 83% depending on the type of chemotherapy employed. 3 H. pylori has been linked to causation of gastric lymphoma several times, [4][5][6] and its eradication may result in complete remission of gastric BL. 7,8 BL seems to have a predisposition in immunosuppressed patients, such as those with HIV or after transplantation.…”

Primary Gastric Burkitt's Lymphoma

“…26 Confirmation of this causal relationship in GIBL has not yet been validated. Studies of sporadic cases have been reported with Helicobacter pylori as causal factor of gastric BL, 25 , 27 , 28 and eradication of Helicobacter pylori leading to a complete remission of gastric BL. 29 , 30 The association of BL with HIV infection is well-known also in the GI tract.…”