Burn injury induces elevated inflammatory traffic: the role of NF-κB

George, Benu; Suchithra, T. V.; Bhatia, Nitish

doi:10.1007/s00011-020-01426-x

Cited by 22 publications

(12 citation statements)

References 124 publications

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“…The transcription factor NF-κB and the multifunctional cytokine TNF-α are potent inflammatory mediators that actively play predominant roles in cellular events such as cell survival, proliferation, differentiation, and death 61 . Researchers have well-established quercetin as a model medication for improving wound healing 53 , 56 , and the current study highlights the beneficial effects of the quercetin-supplemented GbH in the recovery of second-degree burn wounds in rat models.…”

Section: Resultsmentioning

confidence: 99%

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

George

Bhatia

Kumar

et al. 2022

Sci Rep

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Proper burn wound management considers patient’s compliance and provides an environment to accelerate wound closure. Sticky hydrogels are conducive to wound management. They can act as a preventive infection patch with controlled drug delivery and diverse surface adherence. A hypothesis-driven investigation explores a bioinspired polydopamine property in a gelatin-based hydrogel (GbH) where polyvinyl alcohol and starch function as hydrogel backbone. The GbH displayed promising physical properties with O–H group rich surface. The GbH was sticky onto dry surfaces (glass, plastic and aluminium) and wet surfaces (pork and chicken). The GbH demonstrated mathematical kinetics for a transdermal formulation, and the in vitro and in vivo toxicity of the GbH on test models confirmed the models’ healthy growth and biocompatibility. The quercetin-loaded GbH showed 45–50% wound contraction on day 4 for second-degree burn wounds in rat models that were equivalent to the silver sulfadiazine treatment group. The estimates for tensile strength, biochemicals, connective tissue markers and NF-κB were restored on day 21 in the GbH treated healed wounds to imitate the normal level of the skin. The bioinspired GbH promotes efficient wound healing of second-degree burn wounds in rat models, indicating its pre-clinical applicability.

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Section: Resultsmentioning

confidence: 99%

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

George

Bhatia

Kumar

et al. 2022

Sci Rep

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“…20 It can reflect the inflammatory response in the body and is an important indicator of inflammatory infection and poor prognosis. 20 The study by George 21 pointed out that the levels of inflammatory The growth of granulation tissue at the wound surface indicates that the wound is repairing itself, and the granulation tissue can fill the defect tissue, help the wound to shrink, and improve the anti-infection ability of the wound. 24 However, the growth of granulation tissue is closely related to the oxygen environment of the wound tissue.…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin C combined with rbFGF on inflammatory factors and oxygen environment in patients with high‐voltage electrical burns

Zhang¹,

Qin²,

Zhao

et al. 2023

International Wound Journal

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To investigate the effect of vitamin C combined with recombinant basic fibroblast growth factor (rbFGF) on inflammatory factors and oxygen environment in patients with high‐voltage electrical burns. A retrospective analysis of 98 patients with high‐voltage electrical burns admitted to our hospital from January 2021 to April 2022. A total of 98 patients were divided into research group and control group, including 49 cases treated with vitamin C combined with rbFGF and 49 cases treated with only rbFGF. The disappearance time of clinical symptoms, wound healing rate, area of granulation tissue growth, level of inflammatory factors, oxygen environment were compared between two groups after one and three courses of treatment. After treatment, the disappearance time of erythema, pain, swelling, blisters, exudate symptoms, wound healing time, scab formation time, and hospitalisation time in the research group were significantly better than those in control group (P < .05). There was no significant difference in the wound healing rate and area of granulation tissue growth between the two groups after one course of treatment (P > .05), while it is significantly better than those in control group after three courses of treatment (P < .05). The inflammatory factors, succinate dehydrogenase (SDH), lactate dehydrogenase (LDH) scores in research group were significantly better than that in control group after three courses of treatment (P < .05). Vitamin C combined with rbFGF may be worthy to reduce inflammatory factors, regulate oxygen environment, which can be popularised and applied in clinical practice.

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“…The results of Gene Ontology analysis showed that DEGs after burn were related to immune system function, metabolic process, and cellular biological regulation. The results of KEGG pathway enrichment analysis showed that DEGs after burn were mainly located in the Toll-like receptor [ 22 ], p53 [ 23 ], PD-1/PD-L1 [ 24 ], and NF- κ B [ 25 ]. Toll-like receptor signaling pathway can activate bacterial membrane components and promote the activation of MAPK signaling pathway, which in turn triggers the body's inherent immune response and increases the production of proinflammatory factors [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Genes in Severe Burns by Using Weighted Gene Coexpression Network Analysis

Guo

Zhang

Ming

et al. 2022

Computational and Mathematical Methods in Medicine

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The aims of this work were to explore the use of weighted gene coexpression network analysis (WGCNA) for identifying the key genes in severe burns and to provide a reference for finding therapeutic targets for burn wounds. The GSE8056 dataset was selected from the gene expression database of the US National Center for Biotechnology Information for analysis, and a WGCNA network was constructed to screen differentially expressed genes (DEGs). Gene Ontology and pathway enrichment of DGEs were analyzed, and protein interaction network was constructed. A burn mouse model was constructed, and the burn tissue was taken to identify the expression levels of differentially expressed genes. The results showed that the optimal soft threshold for constructing the WGCNA network was 9. 10 coexpressed gene modules were identified, among which the green, brown, and gray modules had the largest number of burn-related genes. The DEGs were mainly related to immune cell activation, inflammatory response, and immune response, and they were enriched in PD-1/PD-L1, Toll-like receptor, p53, and nuclear factor-kappa B (NF-κB) signaling pathways. 5 DEGs were screened and identified, namely, Jun protooncogene (JUN), signal transducer and activator of transcription 1 (STAT1), BCL2 apoptosis regulator (Bcl2), matrix metallopeptidase 9 (MMP9), and Toll-like receptor 2 (TLR2). Compared with skin tissue of normal mouse, the messenger ribose nucleic acid (mRNA) and protein expression levels (PEL) of STAT1 and Bcl2 in burn tissue were greatly decreased, while those of JUN, MMP9, and TLR2 were increased obviously ( p < 0.05 ). In conclusion, STAT1, Bcl2, JUN, MMP9, and TLR2 can be potential biological targets for the treatment of severe burn wounds.

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Burn injury induces elevated inflammatory traffic: the role of NF-κB

Cited by 22 publications

References 124 publications

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

Effects of vitamin C combined with rbFGF on inflammatory factors and oxygen environment in patients with high‐voltage electrical burns

Identification of Key Genes in Severe Burns by Using Weighted Gene Coexpression Network Analysis

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