2013
DOI: 10.1016/j.neuroscience.2012.10.013
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Burn injury induces gelsolin expression and cleavage in the brain of mice

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Cited by 23 publications
(13 citation statements)
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“…The fragmentation of gelsolin by caspases contributes to the morphological change of apoptotic cells (Kothakota et al, 1997). Neuronal cleavage of gelsolin is reported in Alzheimer's disease, spinal cord injury, ischemia and burn injury (Ji et al, 2009; Matsushita et al, 2000; Springer et al, 1999; Zhang et al, 2013). However these studies have mainly focused on the apoptotic roles of caspase-mediated gelsolin cleavage in the nervous system.…”
Section: Discussionmentioning
confidence: 99%
“…The fragmentation of gelsolin by caspases contributes to the morphological change of apoptotic cells (Kothakota et al, 1997). Neuronal cleavage of gelsolin is reported in Alzheimer's disease, spinal cord injury, ischemia and burn injury (Ji et al, 2009; Matsushita et al, 2000; Springer et al, 1999; Zhang et al, 2013). However these studies have mainly focused on the apoptotic roles of caspase-mediated gelsolin cleavage in the nervous system.…”
Section: Discussionmentioning
confidence: 99%
“…Some of these proteins stand out among the others because their functions have been shown to be essential for neuronal function. For example, gelsolin (with two isoforms, one secreted-86 kDa and other cytoplasmic-81 kDa), is a calcium-regulated severing protein recognized by its neuroprotective activity [78][79][80]. Drebrin (48 kDa) binds to F-actin in dendritic spines changing its properties [81].…”
Section: Actin and Actin-binding Proteins (Abps)mentioning
confidence: 99%
“…Vitamin D deficiency is associated with an increase in the risk of developing MS 20, 21 . In our former study we demonstrated that vitamin D could delay the onset of EAE, but could not prevent disease, and this limitation might be associated with the decrease of GSN by vitamin D 22 .…”
Section: Resultsmentioning
confidence: 99%
“…cGSN can be cleaved by caspase-3 upon activation of apoptosis 20 . In our former study, Western blot and flow cytometry were performed to assess whether the level of cGSN in EAE may have a relationship with apoptotic activity and the results supported a role for cGSN in inhibiting apoptosis 22 .…”
Section: Resultsmentioning
confidence: 99%
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