Fuel-air cloud explosions or detonations are often affected by initial ambient conditions. A two-dimensional (2D) semi-confined model was established to study the effects of the inflowing air temperature and initial temperature of the combustor on the explosion process of isopropyl nitrate (IPN)/air mixture. The results showed that at different initial temperatures (1000-3000 K), the first peak pressure (P 1 ) and second peak pressure (P 2 ) decreased with the increase in initial temperature; the maximum flame temperature (2338-3534 K) increased with the increasing initial temperature; the explosion pressure and temperature had the opposite trends with the initial temperature, indicating that the oxygen content in the combustor had a greater impact on the explosion pressure, while the initial temperature had a more significant effect on the flame temperature. Under different incoming air temperatures (1000-3000 K), the flame temperature (~2700 K) of the two-phase explosion had a small difference at the incoming temperature of � 2500 K, signifying that the airflow temperature (< 3000 K) and the oxygen content in air jointly dominated the flame temperature; the flame temperature was 3100 K at the incoming temperature of 3000 K, which was about 300 K higher than other incoming flow temperatures, indicating that the flame temperature was more sensitive to the incoming air temperature (� 3000 K). At 600 m/s airflow, the explosion parameter curves at the inflow temperatures of 300 K and 600 K were compared, and the critical inflow temperature of the explosion process was also investigated.