Burn wound healing activity of ethanol extract gel of Green Algae (Ulva lactuca L) in mice

Abstract

Recently, burn injuries have become a major cause of morbidity and mortality in low-middleincome countries. Burn injuries are tissue loss caused by contact with heat sources such as hot water, fire, chemicals, electricity, and radiation. According to the WHO Global Burden Disease, in 2017 an estimated 180.000 people died from burn injuries. Ethanol extract of green algae (EEGA) contains compounds that potentially heal burn injuries. The research was conducted to obtain a gel formulation from EEGA and test its burn wound healing properties in mice (Mus musculus). Forty-five mice were divided into five groups: I (negative control), II (treated with gel base), III (positive control, Bioplacenton gel), IV (5% EEGA gel), and V (10% EEGA gel). Wound diameters and description scores were observed every fourth, seventh, and fourteenth day, and the derived data were analyzed in the SPSS program with the one-way analysis of variance (ANOVA) and least significance difference (LSD) test. The results indicate that EEGA can be formulated into gels with physical properties compliant with the requirements of the dosage form. Further, it was found that Groups IV and V showed significant reductions in wound description scores and diameters (p<0.05). In conclusion, gels containing 5% and 10% EEGA possess burn wound healing properties.

Green Synthesis and Characterization of Titanium Dioxide Nanoparticles by Aspergillus niger DS22 and Its Potential Application in Medical Fields

“…Besides that, the employing of titanium dioxide nanoparticles (TiO 2 NPs) in the field of medicine, because of their excellent biocompatibility with body tissues, great medicinal potential, and inertia, biomedical applications such as prosthetic hips, bone plates, scaffolds, dental implants, coatings, and drug and gene delivery systems have been developed (Ikram et al, 2021). One of the major issues in clinical settings is the healing of infected wounds (Widyaningsih et al, 2023). Once a burning hurt or a surgical incision has occurred, bacteria quickly colonize the exposed wounds (Roy et al, 2020).The majority of the time, the microorganisms that colonize these wounds are either part of the patient's usual flora or have been transferred from polluted external sources such as water, food, or infected hands of medical personnel (Abbas et al, 2020).…”