Burn wound: How it differs from other wounds?

Tiwari, Varun

doi:10.4103/0970-0358.101319

Cited by 272 publications

(236 citation statements)

References 22 publications

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“…Comparing self-inflicted razor and sodium sulfide (chemical burn) wounds, Bishop observed that chemical wounding kills cells below the level at which dead tissue is produced (Bishop 1945). Similarly, thermal injuries extend beyond the initial burn (Tiwari 2012), and if no adequate measure is taken to improve microcirculation around the initial burn, the adjacent zone of stasis (i.e. where microcirculation has stopped but cells are not quite dead) will undergo necrosis a few days post-burn.…”

Section: Sequence Of Events Leading To Wound Closurementioning

confidence: 99%

Cellular mechanisms of skin repair in humans and other mammals

Rittié

2016

J. Cell Commun. Signal.

243

167

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The increased incidence of non-healing skin wounds in developed societies has prompted tremendous research efforts on the complex process known as Bwound healing^. Unfortunately, the weak relevance of modern wound healing research to human health continues to be a matter of concern. This review summarizes the current knowledge of the cellular mechanisms that mediate wound closure in the skin of humans and laboratory animals. The author highlights the anatomical singularities of human skin vs. the skin of other mammals commonly used for wound healing research (i.e. as mice, rats, rabbits, and pigs), and discusses the roles of stem cells, myofibroblasts, and the matrix environment in the repair process. The majority of this review focuses on reepithelialization and wound closure. Other aspects of wound healing (e.g. inflammation, fibrous healing) are referred to when relevant to the main topic. This review aims at providing the reader with a clear understanding of the similarities and differences that have been reported over the past 100 years between the healing of human wounds and that of other mammals.

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Section: Sequence Of Events Leading To Wound Closurementioning

confidence: 99%

Cellular mechanisms of skin repair in humans and other mammals

Rittié

2016

J. Cell Commun. Signal.

243

167

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“…[25]. Sources of pathogens that are able to infect the burn wounds are from the respiratory and gastrointestinal flora, endogenous and the environment [26]. Good nutrition following burns is advisable since it promotes wound healing.…”

Section: Antimicrobialsmentioning

confidence: 99%

The Burns Menace: Antibiotics for the Fight against Burns Bacterial Infection, a Systemic Review

Agbenorku¹,

Amankwa²,

Agbenorku³

et al. 2016

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Burn wound infection delays wound healing, leading to varying degrees of morbidity and mortality. Various antibiotics are administered to burn patients in burn wound management. The emergence of antibiotic resistance is a menace that costs families and the country. This review seeks to expound on infections related to burn wounds, common bacteria of burn wound infections and choice of antibiotics in burns treatment. Words such as burns, wound infection, burns injury and antibiotics were put into the Google search engine. Only articles related to the subject of burns, burn wound infection and antibiotics were used to write the review. Articles obtained included case reports on burns, research articles, review articles, short notes, briefs, literatures and other articles relating to burns. We found that the choice of antibiotics in the management of burns is an issue of major concern due to the evolution of pathogens causing these infections. The challenge of antibiotic resistance still persists in burns wound management. The commonly used topical antimicrobials included silver sulphadiazine, silver nitrate solution, silver impregnated dressings and mafenide acetate. Mafenide acetate has a wide antibacterial activity and also acts against the usual wound pathogens that were identified:Pseudomonas aeruginosa and Staphylococcus aureus. The role of antibiotic resistance is of major concern. Antibiotics must be administered after culture evidence in order to reduce the chance of increasing evolution of resistant strains of bacteria.

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“…This leaves the victims in the danger of activating an undesired immune response if the material used does not have hemocompatible properties. 1 The typical host response triggered by the synthetic material includes the formation of thrombosis, inflammation, and foreign body reaction. This will further delay the healing process which usually take years for complete epithelization and maturation.…”

Section: Hemocompatibility Of Bio-nanofibrous Dressing Materialsmentioning

confidence: 99%

“…Pain and the generalized effects on the body experienced by a burn victim are incomparable with other traumas. [1][2][3][4] Initial pathophysiological events associated with burn wound healing include hemostasis and onset of a prolonged inflammatory phase. This leads to the release of several proteins, and formation of edema and exudate at the wound site.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

Balaji

Jaganathan

Ismail

et al. 2016

IJN

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Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in burn victims. To assist burn wound management, a novel polyurethane (PU)-based bio-nanofibrous dressing loaded with honey (HN) and Carica papaya (PA) fruit extract was fabricated using a one-step electrospinning technique. The developed dressing material had a mean fiber diameter of 190±19.93 nm with pore sizes of 4–50 µm to support effective infiltration of nutrients and gas exchange. The successful blending of HN- and PA-based active biomolecules in PU was inferred through changes in surface chemistry. The blend subsequently increased the wettability (14%) and surface energy (24%) of the novel dressing. Ultimately, the presence of hydrophilic biomolecules and high porosity enhanced the water absorption ability of the PU-HN-PA nanofiber samples to 761.67% from 285.13% in PU. Furthermore, the ability of the bio-nanofibrous dressing to support specific protein adsorption (45%), delay thrombus formation, and reduce hemolysis demonstrated its nontoxic and compatible nature with the host tissues. In summary, the excellent physicochemical and hemocompatible properties of the developed PU-HN-PA dressing exhibit its potential in reducing the clinical complications associated with the treatment of burn injuries.

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Burn wound: How it differs from other wounds?

Cited by 272 publications

References 22 publications

Cellular mechanisms of skin repair in humans and other mammals

Cellular mechanisms of skin repair in humans and other mammals

The Burns Menace: Antibiotics for the Fight against Burns Bacterial Infection, a Systemic Review

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

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