Burn Wound Microbiology and the Antibiotic Susceptibility Patterns of Bacterial Isolates in Three Burn Units of Abbottabad, Pakistan

Hubab, Muhammad; Maab, Hira; Hayat, Azam; Rehman, Mujaddad Ur

doi:10.1093/jbcr/iraa073

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Because microorganism composition may be different by specimen type ( Frikh et al., 2018 ), we further analyzed the pathogen distribution in different clinical sample types. Although Gram-negative bacteria were predominant in wounds from patients in BICU and BCW, S. aureus were the most common bacteria, which is consistent with previous studies ( El Hamzaoui et al., 2020 ; Hubab et al., 2020 ) and data on the China Antimicrobial Surveillance Network (CHINET) ( Hu et al., 2018 ). This could be partly explained by staphylococcus being the main normal flora in skin, but the number of common Gram-positive bacteria types are lower than those of common Gram-negative bacteria types ( Ladhani et al., 2020 ).…”

Section: Discussionsupporting

confidence: 90%

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Gong

Peng

Luo

et al. 2021

Front. Cell. Infect. Microbiol.

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Infection is the leading cause of complications and deaths after burns. However, the difference in infection patterns between the burn intensive care unit (BICU) and burn common wards (BCW) have not been clearly investigated. The present study aimed to compare the infection profile, antimicrobial resistance, and their changing patterns in burn patients in BICU and BCW. Clinical samples were analyzed between January 1, 2011, and December 31, 2019, in the Institute of Burn Research in Southwest China. The patient information, pathogen distribution, sources, and antimicrobial resistance were retrospectively collected. A total of 3457 and 4219 strains were detected in BICU and BCW, respectively. Wound secretions accounted for 86.6% and 44.9% in BCW and BICU, respectively. Compared with samples in BCW, samples in BICU had more fungi (11.8% vs. 8.1%), more Gram-negative bacteria (60.0% vs. 50.8%), and less Gram-positive bacteria (28.2% vs. 41.1%). Acinetobacter baumannii were the most common pathogen in BICU, compared with Staphylococcus aureus in BCW. S. aureus was the most frequent pathogen in wound secretions and tissues from both BICU and BCW. However, A. baumannii were the first in blood, sputum, and catheter samples from BICU. Overall, the multidrug-resistance (MDR) rate was higher in BICU than in BCW. However, the gap between BICU and BCW gradually shortened from 2011 to 2019. The prevalence of MDR A. baumannii and Klebsiella pneumonia significantly increased, especially in BCW. Furthermore, Carbapenem resistance among K. pneumoniae significantly increased in BICU (4.5% in 2011 vs. 40% in 2019) and BCW (0 in 2011 vs. 40% in 2019). However, the percentage of MDR P. aeruginosa sharply dropped from 85.7% to 24.5% in BICU. The incidence of MRSA was significantly higher in BICU than in BCW (94.2% vs. 71.0%) and stayed at a high level in BICU (89.5% to 96.3%). C. tropicalis and C. albicans were the two most frequent fungi. No resistance to Amphotericin B was detected. Our study shows that the infection profile is different between BICU and BCW, and multidrug resistance is more serious in BICU than BCW. Therefore, different infection-control strategies should be emphasized in different burn populations.

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Section: Discussionsupporting

confidence: 90%

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Gong

Peng

Luo

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Males are less concerned about their health because of their large family (6). In the study conducted by Tasnim and Hubab et al (8,9), the incidence of men with burn trauma was found to be higher. Our work is in line with this.…”

Section: Discussionmentioning

confidence: 99%

Wound changes following delayed admission to the Burn center

Yiğit,

Yiğit

2023

Sanamed

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Introduction: This retrospective clinical study aimed to investigate patient profiles and wound degree changes, as well as cultural details, resulting from delayed admissions to burn centers following burn trauma. Methods: Patients were categorized into five groups based on the time of hospital admission after the burn trauma: 0 days, 1st day, 2nd day, 3rd day, and 4 th day and beyond. Results: During the study period, 1092 patients were admitted to the hospital on the day of their burn trauma. A total of 324 (22.8%) patients-131 (40.4%) women and 193 (59.6%) men were admitted to the hospital 1 day or more after the trauma. These patients were admitted to the hospital 3.77 (min=1, max=27 ) days after receiving the burn, on average. Of the 324 patients admitted to the hospital after 1 day, 57.9% were rural residents, and 42.1% were urban residents. The most common cause of wound site infection was Staphylococcus aureus, with 20.18%. No statistically significant difference existed between the number of days of delayed hospital admission and the duration of hospitalization. Conclusion: Delays in hospital admission significantly influence changes in burn wound conditions.

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“…Cultures confirm that 9-54% of patients in the pediatric burn unit are polluted with pathogenic bacteria at the time of admission [4]. Despite advances in topical and intravenous antimicrobial therapies, as well as the technique of immediate transverse eradication, bacteria remain a serious problem in the treatment of burn victims [5]. Moreover, due to overcrowding in burn hospitals, cross-infection occurs between different burn patients [6].…”

Section: Introductionmentioning

confidence: 99%

Detection of Bacteria Causing Burn Infection Isolated from Several Hospitals in Baghdad

Al-Azzawi

Al-Kalifawi

2023

IHJPAS

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The results of the present study showed that twenty-five samples were collected for the age group 35–40 years and four samples for the age group 65–70 years for both genders. The results showed that 48 (48%) of the samples were obtained from the hands, 16 (16%) from the legs, 12 (12%) from the abdominal area, and 10 (10%) from the chest area. The four (4%) samples were obtained from burns in the back and thighs area. The samples taken according to the cause of burns were 40 (40%) due to hot water, hot liquids, or hot steam, followed by 18 (18%) due to the use of hot tools, 15 (15%) due to fires, 12 (12%) due to electric currents, 10 (10%) due to chemicals such as strong acids, alkaline lye, paint thinner, or gasoline, and 5 (5%) due to sun ray burns. Sixty pathogenic bacteria were obtained from the burn samples. The number of bacteria isolated from burn wounds was 34 isolates from men and 26 isolates from women. The predominant were 15 (25%) Staphylococcus aureus, 12 (20%) Acinetobacter baumannii, 10 (16.7%) Pseudomonas aeruginosa, 8 (13.3%) Klebsiella pneumoniae, 7 (11.7%) Escherichia coli, 6 (10%) Proteus mirabilis, and 2 (3.3%) Burkholderia cepacia. The antibiotic sensitivity test using the Vitek2 Compact System showed that the resistance rate was recorded in Staphylococcus aureus against Amikacin by 13 isolates, with a rate of 86.6%, and in Acinetobacter baumannii, towards Ceftazidime and Piperacillin antibiotics by 12 isolates at a rate of 100%, and Pseudomonas aeruginosa towards Colistin and Tobramycin at a rate of 6 isolates at a rate of 60%, and Klebsiella pneumoniae towards Colistin and Tobramycin at a rate of 8 isolates at a rate of 100% and Escherichia coli against Amikacin, Colistin, and Imipenem with 7 isolates and 100%, and Proteus mirabilis against Colistin and Tobramycin with 6 isolates and 100%, and Burkholderia cepacia against 8 antibiotics with a rate of 100%. We conclude from the present study that the most susceptible age group to burns is the active age group and that the pathogenic bacteria from burn wounds are mostly resistant to antibiotics.

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Burn Wound Microbiology and the Antibiotic Susceptibility Patterns of Bacterial Isolates in Three Burn Units of Abbottabad, Pakistan

Cited by 7 publications

References 20 publications

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Wound changes following delayed admission to the Burn center

Detection of Bacteria Causing Burn Infection Isolated from Several Hospitals in Baghdad

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