Burned-out hippocampus syndrome: myth or reality? A case report

A medically refractory epilepsy case with discordant presurgical findings: The pitfall of burned‐out hippocampus

“…Proposed explanation for this phenomenon is as follows: In atrophic hippocampus, neuronal loss is so severe that it cannot cause ipsilateral neocortical activation, yet ictal activity may spread to contralateral hippocampus and temporal neocortex via dorsal hippocampal commissure 5 . Thus, scalp‐EEG findings occur in contralateral temporal lobe 6,7 . Hence it is currently not easy to solve this EZ lateralization challenge with non‐invasive EEG recordings.…”

“…5 Thus, scalp-EEG findings occur in contralateral temporal lobe. 6,7 Hence it is currently not easy to solve this EZ lateralization challenge with non-invasive EEG recordings. Awareness of this phenomenon is important for a favorable surgical outcome, as up to 80% of burnedout hippocampus cases can be seizure-free.…”