Burning Mouth Syndrome: A Therapeutic Approach Involving Mechanical Salivary Stimulation

Souza, Fabrício Tinôco Alvim de; Amaral, Tânia Mp; Santos, Tálita Pollyanna Moreira dos; Abdo, Evandro Neves; Aguiar, Maria Cássia Ferreira de; Teixeira, Antônio Lúcio; Kümmer, Arthur; Abreu, Mauro Henrique Nogueira Guimarães de; Silva, Tarcı́lia Aparecida

doi:10.1111/j.1526-4610.2011.02037.x

Cited by 28 publications

(22 citation statements)

References 34 publications

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“…Similarly, the levels of IgE did not significantly vary between resting and mechanically stimulated saliva, further highlighting the potential use of either method in a clinical setting when determining levels for monitoring immune response [32]. The effectiveness of mechanical stimulation as opposed to other methods of collecting saliva and detecting clinically-relevant proteins has been confirmed in previous studies [33-35]. Mechanically stimulated saliva is known to be predominantly derived from the parotid gland and consists mainly of water [27].…”

Section: Discussionmentioning

confidence: 79%

The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassays

Mohamed¹,

Campbell²,

Cooper-White

et al. 2012

Clinical & Translational Med

133

106

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Background Owing to its ease of collection, saliva is potentially the sample of choice in diagnosis. Salivary biomolecules have provided a porthole in surveying a person's health and well‐being. Our study aims were (1) to demonstrate the effects of pre‐analytical steps, collection and pre‐processing techniques on salivary protein detection and (2) to establish an indication of salivary reference intervals for 3 biomolecules of clinical interest. Methods Saliva samples were collected from participants (n = 25, ages 20–35 years) using the following methods: no stimulation (resting/unstimulated), mechanical, and acid stimulation. The saliva was prepared for analysis by: unprocessed, post standard centrifugation in a container without any additives, and centrifugation using Centrifugal Filter Unit (Amicon® Ultra‐0.5). AlphaLisa® assays were used to measure the levels of C‐Reactive Protein (CRP), Immunoglobin (IgE) and myoglobin in saliva samples. Results Saliva flow rates were lowest with the resting/drooling collection method. The lowest total protein concentration was with acid stimulation. Unstimulated and mechanically stimulated collections produced no effect on the CRP and IgE levels while myoglobin levels were highest with the unstimulated collection. Acid stimulation had a negative impact on the measured concentrations of IgE and myoglobin (except for CRP levels). Conclusion Mechanical stimulation was the most viable option for collecting saliva without affecting the levels of CRP and myoglobin. The processing methods had an adverse effect on the concentration of total protein as well as on CRP and IgE concentrations.

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Section: Discussionmentioning

confidence: 79%

The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassays

Mohamed¹,

Campbell²,

Cooper-White

et al. 2012

Clinical & Translational Med

133

106

View full text Add to dashboard Cite

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“…Borelli et al reported that nerve growth factor (NGF) peptide and tryptase activity were significantly and persistently higher in saliva of BMS subjects (Borelli et al, 2010). In a recent study, de Souza et al observed a significant reduction in the burning sensation and number of burning sites, as well as an improvement in taste disturbances and xerostomia, after mechanical salivary stimulation (de Souza et al, 2012). In their study, salivary stimulation therapy resulted in a significant decrease in salivary levels of total protein and an increase in tumor necrosis factor (TNF)-a.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of salivary function in patients with burning mouth syndrome

Lee

Hong

et al. 2014

Oral Diseases

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OBJECTIVES: To investigate salivary function in patients with primary burning mouth syndrome (BMS) compared with control and to evaluate salivary hypofunction using salivary gland scintigraphy (SGS). METHODS: A total of 33 patients with primary BMS and 30 control subjects were enrolled in our study. The severity of the pain and the burning sensation on a 10-cm visual analog scale (VAS) and the Oral Health Impact Profile-14 (OHIP-14) were assessed. Unstimulated and stimulated salivary flow rates (SFRs) were measured.99m Tc pertechnetate SGS was used to evaluate salivary gland function. RESULTS: Unstimulated SFR in patients with BMS was significantly lower than that in the control group (0.11 AE 0.15 vs 0.21 AE 0.16 ml min À1, P = 0.014). There was no significant difference in stimulated SFR between the two groups. The VAS scores for oral pain and burning sensation, the total OHIP-14 score, and salivary gland function by salivary scintigraphy were not significantly different between BMS patients with normal flow rate and hyposalivation. CONCLUSIONS: Patients with primary BMS exhibited a significant decrease in unstimulated SFR compared with control group. In addition, we could not find any difference in salivary gland function between BMS patients with or without hyposalivation. Oral Diseases (2015) 21, 308-313

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“…Another study also reported a decrease in serum TNF-α levels in this group [29], but yet others showed no significant differences between patients and controls regarding levels of salivary TNF-α [30,31]. Interestingly, BMS patients subjected to salivary stimulation therapy demonstrated a significant reduction of symptoms in parallel with a decrease in the salivary levels of total protein and an increase in TNF-α [32]. Elevated salivary concentrations of IL-6 in BMS patients have also been reported by some authors [8], but not by others [30,31].…”

Section: Discussionmentioning

confidence: 99%

The Association of Openness Personality Trait with Stress-Related Salivary Biomarkers in Burning Mouth Syndrome

Souza¹,

Kümmer²,

Silva³

et al. 2014

Neuroimmunomodulation

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Background: Burning mouth syndrome (BMS) is a chronic disorder defined as a burning sensation in the oral mucosa without evidence of pathological findings. Its pathophysiology is largely unknown, but psychiatric disorders and personality traits have been implicated. Objective: This study investigated whether there is any association between salivary biomarkers and personality traits in BMS patients. Methods: It was a cross-sectional, controlled study that evaluated 30 individuals with BMS and 32 controls. All subjects were assessed with a structured psychiatric interview (Mini International Neuropsychiatric Interview) and the Big Five inventory. Salivary levels of brain-derived neurotrophic factor (BDNF), neural growth factor, tumor necrosis factor-α, interleukin (IL)-6, IL-10 and cortisol were determined. Results: We found that BMS patients exhibited more traits of neuroticism and lower openness than controls. Openness showed a moderate and negative correlation with cortisol, BDNF and IL-6. Conclusion: Personality traits are associated with salivary biomarkers in BMS.

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Burning Mouth Syndrome: A Therapeutic Approach Involving Mechanical Salivary Stimulation

Abstract: Salivary mechanical stimulation therapy is effective in reducing clinical symptoms of BMS.

Cited by 28 publications

References 34 publications

The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassays

The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassays

Evaluation of salivary function in patients with burning mouth syndrome

The Association of Openness Personality Trait with Stress-Related Salivary Biomarkers in Burning Mouth Syndrome

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