Burning Mouth Syndrome: Will Better Understanding Yield Better Management?

Maltsman-Tseikhin, Alexander; Moricca, Paolo; Niv, David

doi:10.1111/j.1533-2500.2007.00124.x

Cited by 72 publications

(71 citation statements)

References 84 publications

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“…Frequently several factors coincide, increasing the harmful effect on the mucosa, whether perceptible or not by the observer (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Etiopathogenesismentioning

confidence: 99%

“…This theory proposes that certain people, labeled as supertasters due to the high density of fungiform papillae present on the anterior part of the tongue, are more susceptible to developing burning mouth pain. Supertasters are principally women, and are able to perceive the bitter taste of a substance called PROP (6-n-propiltiouracilo) (4)(5)(6)(7)(8).…”

Section: Local Factorsmentioning

confidence: 99%

“…It as a chronic orofacial pain, unaccompanied by mucosal lesions or other evident clinical signs upon examination (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The International Association for the study of Pain defines it as a pain of at least 4-6 months duration located on the tongue or other mucosal membranes in the absence of clinical or laboratory findings.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Burning mouth syndrome: An update

López‐Jornet¹,

Camacho-Alonso²,

et al. 2010

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Burning mouth syndrome (BMS) refers to chronic orofacial pain, unaccompanied by mucosal lesions or other evident clinical signs. It is observed principally in middle-aged patients and postmenopausal women. BMS is characterized by an intense burning or stinging sensation, preferably on the tongue or in other areas of the oral mucosa. It can be accompanied by other sensory disorders such as dry mouth or taste alterations. Probably of multifactorial origin, and often idiopathic, with a still unknown etiopathogenesis in which local, systemic and psychological factors are implicated. Currently there is no consensus on the diagnosis and classification of BMS. This study reviews the literature on this syndrome, with special reference to the etiological factors that may be involved and the clinical aspects they present. The diagnostic criteria that should be followed and the therapeutic management are discussed with reference to the most recent studies.

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“…Frequently several factors coincide, increasing the harmful effect on the mucosa, whether perceptible or not by the observer (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Etiopathogenesismentioning

confidence: 99%

Section: Local Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Burning mouth syndrome: An update

López‐Jornet¹,

Camacho-Alonso²,

et al. 2010

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“…3 The aetiology of BMS is poorly understood and considered multifactorial, being associated with various local, systemic, psychogenic and neurological causes. [4][5] Therapy is empiric and without evidence of effi cacy, leaving the condition with no recognised treatment. 6 The disorder, often of an unknown ethiopathogenesis, still presents substantial clinical, diagnostic and therapeutic problems.…”

mentioning

confidence: 99%

Burning mouth syndrome: is acupuncture a therapeutic possibility?

Scardina¹,

Ruggieri

Provenzano

et al. 2010

Br Dent J

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is fairly common, which explains the increased attention that the condition has received in the recent literature. 3 The aetiology of BMS is poorly understood and considered multifactorial, being associated with various local, systemic, psychogenic and neurological causes. [4][5] Therapy is empiric and without evidence of effi cacy, leaving the condition with no recognised treatment. 6 The disorder, often of an unknown ethiopathogenesis, still presents substantial clinical, diagnostic and therapeutic problems. Due to the absence of a clear clinical objective assessment for this disorder and the lack of a defi nite understanding of its ethiopathogenesis, the clinical interpretation and treatment of BMS remains problematic. Among the possible risk factors of BMS are numerous physiopathological situations where the microcirculatory mechanisms are involved in pain generation. Recent research has revealed an alteration of the oral district microcirculation in patients with BMS.The vasomodulatory effect of acupuncture has been proven through elegant thermographic methods that show how acupuncture is able to operate a microcirculatory modifi cation. In addition, it INTRODUCTIONBurning mouth syndrome (BMS) is a painful syndrome whose frequency in the general population is quite signifi cant. According to recent studies, the syndrome affects 3.7% of the general population and is more common in women (5.5%) -particularly after menopause -than in men (1.6%). 1The disorder is characterised by a burning or itching sensation preferentially located at the tip and sides of the tongue, lips and anterior palate, in the absence of evidence of oral mucosal pathology, and sometimes associated with taste alterations and dry mouth. 2 The syndrome is more common in women than in men, with the peak prevalence corresponding to females in the fourth to sixth decades of life. Several studies indicate that BMS Background Burning mouth syndrome is a chronic pathology of unknown ethiopathogenesis. The aim of this study was to evaluate whether acupuncture can produce a reduction of the burning sensation by infl uencing the oral microcirculation. Methods Thirty patients (10 male and 20 female; mean age ± SD = 65.4 ± 2.17) and 30 healthy subjects (10 male and 20 female; mean age ± SD = 62.06 ± 6.72) were recruited for the study. The patients were treated with acupunctural techniques based on traditional Chinese medicine. Microcirculation was observed in vivo using videocapillaroscopy at three different times: t 0 ) in the absence of acupuncture; t 1 ) 1 minute after the insertion of the needles; and t 2 ) 5 minutes after the insertion of the needles and following their stimulation. Results The capillaroscopic observation revealed a signifi cant increase of the capillary tortuousness and density, a reduction of the arborescence and a reduction of burning sensation in such patients. Conclusion The study shows that acupuncture infl uences oral microcirculation, resulting in a signifi cant variation of the vascular pattern to which is associated a s...

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“…The etiology of this disorder is poorly understood even though new evidence for a possible neuropathic patho- genesis of idiopathic BMS is emerging [4].…”

Section: Discussionmentioning

confidence: 99%

Histological effect of ovariectomy and estrogen replacement on parotid gland of adult albino rat

Mohamed¹,

Elnegris²,

Wahdan³

2015

J Histol Histopathol

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Introduction: Many women undergo hormone replacement therapy in order to relief the menopausal and postmenopausal symptoms. Oral discomfort is common among these symptoms. Aim of work:This work aimed to study the possible histological changes of parotid gland associated with ovariectomy and to assess the possible beneficial role of estrogen replacement. Materials and methods: Thirty healthy adult female albino rats were equally divided into three main groups. Group I: Served as control that was subdivided into two subgroups; the sham operated (Ca) and vehicle-treated (Cb). Group II was the experimental group overiectomized (OVX) one. Group III: was treated with 17_-estradiol (E2) (Teikoku Hormone Mfg. Co., Ltd., 50 mg per day) consecutively for 14 days. At the time of sacrifice, the rats were anaesthetized and specimens from parotid of all rats were stained by H&E and Mallory trichrome stains. The percent of collagen fiber and diameter of ducts were measured. Morphometrical results were statistically analyzed. Immunohistochmical staining for Cu, Zn-SOD was also performed to assess the role of estrogen supplementation. Results: Examination of parotid in OVX group showed different forms of degenerative changes. The acini appeared irregular and lined with some apoptotic cells. Their cytoplasm contained extensive vacuolations. Homogenous acidophilic material, cellular infiteration within thick CT septa, dilated ducts with stratification in their lining and congestion of blood vessels were also seen. Positive immunostaining for Cu, Zn-SOD appeared in acinar cytoplasm. Ultrastructurally, rarified dilated RER, electron dence and lucent granules were also seen. Estrogen replacement improved the histological changes in treated group. Conclusion: Results obtained in this study suggest that estrogen deficiency in postmenopausal women lead to variable degenerative changes in parotid salivary glands of adult female albino rats with relative limitation of these changes in estrogen supplemented group.

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Burning Mouth Syndrome: Will Better Understanding Yield Better Management?

Cited by 72 publications

References 84 publications

Burning mouth syndrome: An update

Burning mouth syndrome: An update

Burning mouth syndrome: is acupuncture a therapeutic possibility?

Histological effect of ovariectomy and estrogen replacement on parotid gland of adult albino rat

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