Burning Mouth Syndrome

Klein, Brittany A.; Thoppay, Jaisri R.; Rossi, Scott S. De; Ciarrocca, Katharine

doi:10.1016/j.det.2020.05.008

Cited by 38 publications

(52 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 2D image analysis revealed a total of 141 spots that were matched between the two groups. Considering those, nine spots (2,43,58,118,141,170,174,192,209) were observed to present a different relative abundance between the healthy and BMC groups (p < 0.05), when univariate analysis was performed and, therefore, were selected for identification by mass spectrometry (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The literature also contemplates other terms describing this disorder, such as glossodynia or stomatopyrosis, referring mainly to a burning sensation of the oral mucosa and not to the global symptoms that conform the syndrome. The term “burning mouth syndrome”, therefore, is considered to be the most appropriate [ 2 ]. The etiology of BMS is unclear, although a number of factors have been closely related to the appearance of the symptoms, such as anxiety and/or depression, and sleep disturbances [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

Castillo-Felipe

Franco‐Martínez

López‐Jornet³

et al. 2021

Biology

View full text Add to dashboard Cite

Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and/or diagnosis.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

Castillo-Felipe

Franco‐Martínez

López‐Jornet³

et al. 2021

Biology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…With this exploratory experimental study we investigated the modulatory role of olfactory and gustatory stimuli in chronic oral burning pain, a disabling condition that is difficult to manage and treat (Klein et al, 2020). We aimed to determine whether smell and/or taste stimuli We found that the unpleasant chemosensory stimuli altered pain unpleasantness without changing pain intensity perception, underlining the dissociation between the sensory and the affective dimensions of pain in this kind of chronic oral pain.…”

Section: Discussionmentioning

confidence: 99%

Unpleasant olfactory and gustatory stimuli increase pain unpleasantness in patients with chronic oral burning pain: An exploratory study

Sandri

Cecchini

Zanini

et al. 2022

European Journal of Pain

View full text Add to dashboard Cite

Background: Despite mounting evidence for the powerful influence of smell and taste substances in experimental pain, our knowledge of their effects in the clinical context is scarce, especially for patients with chronic oral burning pain.To fill this gap, we investigated the effect of olfactory and gustatory stimuli on pain perception in patients with chronic oral burning pain, a disabling condition that is difficult to manage and treat.Methods: Twenty-two patients with chronic oral burning pain underwent testing with a variety of olfactory and gustatory substances (pleasant, neutral, unpleasant) in multisensory interaction. The order of testing was randomized. Perception of pain intensity and unpleasantness was evaluated on a numerical rating scale at baseline and immediately after each test trial.Results: Pain unpleasantness but not pain intensity was found to be modulated by chemosensory stimuli. Unpleasant olfactory and gustatory stimuli increased the perception of pain unpleasantness compared to pleasant and neutral stimuli.Pain unpleasantness after unpleasant olfactory and gustatory stimuli correlated with psychological questionnaire subscale scores for distress (CORE-OM) and emotional awareness (TAS-20).

show abstract

“…In the current study, we found that chronic disease increased the risk of developing BMS after adjusting for sex, age, highest education level achieved, previous-month household income, smoking, and alcohol use. The reason for this could be that systemic factors, including anemia, diabetes, thyroid disease, hormonal de ciency, upper respiratory tract infection, gastroesophageal re ex disease, Parkinson's disease, and side effects of antihypertensive medications, were associated with BMS [23].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of oral mucosal lesions and their association with socioeconomic status and systemic health in a remote rural area in China: a cross-sectional study of 146 cases

Yao

Zhang

Song

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Epidemiological data of oral mucosal lesions (OMLs) are required to develop practical oral care policies. However, limited data are available for rural areas in China. We aimed to estimate the spectrum and prevalence of OMLs and to identify their associated socioeconomic status (SES) and systemic health in a remote rural area in Yunnan, China. Methods We screened patients for OMLs in an oral medicine clinic in rural Yuannan, China, from August 2020 to February 2021. OMLs were documented. SES, including the highest education level achieved and the previous month’s household income, as well as the patient’s systemic health, including a history of smoking, alcohol use, and chronic disease, were obtained from the Medical History/Health Questionnaire Form and patient medical records. Results A total of 146 patients were found to have OMLs. The most frequent OML was aphthous ulcer (n = 41, 28.1%), followed by burning mouth syndrome (BMS) (n = 16, 11.0%), viral ulcer (n = 14, 9.6%), and oral lichen planus (OLP) (n = 9, 6.2%). In these patients, the most common chronic diseases were sleep apnea (n = 35, 24.0%), hypertension (n = 23, 15.8%), bronchitis (n = 16, 11.0%), reflux (including gastroesophageal reflux disease) (n = 12, 8.2%), and arthritis (n = 11, 7.5%). On adjusted regression, the patients without chronic diseases had a lower risk of BMS than those with chronic diseases (odds ratio [OR], 0.2; 95% confidence interval [CI], 0.03–0.9). Age was an independent protective factor for viral ulcers (OR, 1.0; 95% CI, 0.9–1.0). Patients with low-income levels had a lower risk of OLP than those with high-income levels (OR, 0.2; 95% CI, 0.05–0.9). Conclusions In rural Yunnan in China, the most frequent OML was aphthous ulcer, which was followed by BMS, viral ulcer, and OLP. Chronic diseases were associated with BMS. Age was an independent protective factor for oral viral ulcers. A high-income level was associated with the presence of OLP. Oral care policies should be prioritized among patients with aphthous ulcer. Preventive strategy of BMS should be targeted to people with chronic disease for health equalities.

show abstract

Burning Mouth Syndrome

Cited by 38 publications

References 32 publications

Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

Unpleasant olfactory and gustatory stimuli increase pain unpleasantness in patients with chronic oral burning pain: An exploratory study

Characteristics of oral mucosal lesions and their association with socioeconomic status and systemic health in a remote rural area in China: a cross-sectional study of 146 cases

Contact Info

Product

Resources

About