Burns and long-term infectious disease morbidity: A population-based study

Duke, Janine M.; Randall, Sean; Wood, Fiona; Boyd, James H.; Fear, Mark W.

doi:10.1016/j.burns.2016.10.020

Cited by 36 publications

(22 citation statements)

References 41 publications

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“…While a growing body of work indicates that serious injury suppresses immune function [ 8 , 10 – 12 ] recent animal-based research found long-term immune dysfunction after non-severe burn injury [ 13 ]. These results were supported by our previous study, which found increased infectious disease morbidity among burn patients after both minor and severe burns, for a prolonged period after discharge, when compared with an age gender matched cohort of uninjured people [ 14 ]. In this study, burn patients were found to have significantly elevated rates of first-time infectious disease admissions after discharge with rates reducing in magnitude from five times higher during the first 30 days post-discharge, 1.7 times higher for the remainder of the first year and 1.4 times higher for the following 9 years.…”

Section: Introductionsupporting

confidence: 84%

“…In this study, burn patients were found to have significantly elevated rates of first-time infectious disease admissions after discharge with rates reducing in magnitude from five times higher during the first 30 days post-discharge, 1.7 times higher for the remainder of the first year and 1.4 times higher for the following 9 years. Respiratory, skin and soft tissue and gastrointestinal infections were the most commonly observed primary reason for a post-injury infectious disease hospital admission in this burn cohort [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

et al. 2018

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BackgroundInjury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital admissions data.MethodsA retrospective longitudinal study using linked health data of all patients admitted with burns in Western Australia (n = 30,997), 1980–2012, and age and gender frequency matched cohorts of people with non-burn trauma (n = 28,647) and no injury admissions (n = 123,399). Analyses included direct standardisation, negative binomial regression and Cox proportional hazards regression.ResultsAnnual age-standardised infectious disease admission rates were highest for the burn cohort, followed by the non-burn trauma and uninjured cohorts. Age-standardised admission rates by decade showed different patterns across major categories of infectious diseases, with the lower respiratory and skin and soft tissue infections the most common for those with burns and other open trauma. Compared with the uninjured, those with burns had twice the admission rate for infectious disease after discharge (incident rate ratio (IRR), 95% confidence interval (CI): 2.04, 1.98–2.11) while non-burn trauma experienced 1.74 times higher rates (95%CI: 1.68–1.81). The burn cohort experienced 10% higher rates of first-time admissions after discharge when compared with the non-burn trauma (hazard ratio (HR), 95%CI: 1.10, 1.05–1.15). Compared with the uninjured cohort, incident admissions were highest during the first 30 days after discharge for burns (HR, 95%CI: 5.18, 4.15–6.48) and non-burn trauma (HR, 95%CI: 5.06, 4.03–6.34). While incident rates remained high over the study period, the magnitude decreased with increasing time from discharge: burn vs uninjured: HR, 95%CI: 30 days to 1 year: 1.69, 1.53–1.87; 1 to 10 years: 1.40, 1.33–1.47; 10 years to end of study period: 1.16, 1.08–1.24; non-burn trauma vs uninjured: HR, 95%CI: 30 days to 1 year: 1.71, 1.55–1.90; 1 to 10 years: 1.30, 1.24–1.37; 10 years to end of study period: 1.09, 1.03–1.17).ConclusionsBurns and non-burn trauma patients had higher admission rates for infectious diseases compared with age and gender matched uninjured people. The pattern of annual admission rates for major categories of infectious diseases varied across injury groups. Overall, the burn cohort experienced the highest rates for digestive, lower respiratory and skin and soft tissue infections. These results suggest long-term vulnerability to infectious disease after injury, possibly related to long-term immune dysfunction.

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Section: Introductionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

et al. 2018

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“…Bu infeksiyonların yayılımının artması sonucunda, kısmi kalınlıklı yara tam kat yaraya dönüşebilir. İnvaziv yara infeksiyonlarında kültür sonucuna göre sistemik antibiyotik kullanımı gereklidir (16).…”

Section: Akutunclassified

Yanıklarda Akut Dönem ve Hemşirelik Bakımı

Sayılan¹,

Ak²,

Kanan³

2018

Sağlık Bilimleri Ve Meslekleri Dergisi

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ÖZ Yanık; özel, yoğun ve uzun süreli tedavi gerektiren cerrahi bir travmadır. Yanıkta akut dönem ise, yanığın olumsuz etkilerine karşı organizmayı hazırlıklı hale getirmek amacıyla, oluşan bir dizi reaksiyonlar bütünü olarak tanımlanmaktadır. Yanık hastasında, cilt bariyeri bozulduğu için ciddi sıvı, elektrolit, protein, mineral kayıpları olmakta; yoğun katabolik durum, infeksiyonlar ve yara iyileşmesi sonucunda artan gereksinimler nedeni ile protein, enerji ve mikrobesin ögesi eksiklikleri gelişebilmektedir. Bu nedenle, yanığın akut dönem tedavi ve bakımında; yara bakımı, infeksiyon kontrolü, ağrı yönetimi, fizik tedavi ve beslenme önemli rol oynamaktadır. Sağlık bakım ekibi içinde yer alan hemşirelerin yanıklı hastanın bakımındaki rol ve sorumlulukları büyüktür. Bu derlemede; yanıklarda akut dönem ve hemşirelik bakımına yer verilmiştir.

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“…In the world, approximately 265,000 deaths occur annually, which represents a severe public health problem [1]. Studies have been reporting that skin injuries are related to microbial colonization, suppressing the immune function predisposing the people to infectious diseases [2]. Hassen, et al [3], reported that the most commonly isolated bacteria in burn children were methicillin-susceptible Staphylococcus aureus (MSSA, 57.7%), Pseudomonas aeruginosa (35.9%), and Enterobacter cloacae (26.9%) wild types [3].…”

Section: Introductionmentioning

confidence: 99%

Medicinal plant extract associated with bacterial cellulose membrane: Antibacterial activity and physicochemical properties

Batain¹,

Crescencio²,

Alves³

et al. 2020

Arch Pharm Pharma Sci

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Burns injuries induce a state of immunodepression that predisposes to a bacterial infectious complication that leads to several comorbid diseases and high mortality rate. Previous studies about anti-infl ammatory, antimicrobial and antioxidant properties of Aloe vera (L.) Burm., Calendula offi cinalis L. and Matricaria recutita L. are acknowledge by antimicrobial effects. Previous studies about anti-infl ammatory, antimicrobial and antioxidant properties of Aloe vera (L.) Burm., Calendula offi cinalis L. and Matricaria recutita L. are knowledge by antimicrobial effects. Bacterial cellulose membrane (nature BCM) is a potential carrier as a drug delivery system in the wound and burn treatment. The present study aimed to evaluate the antibacterial activity of extracts of A. vera, C. offi cinalis, and M. recutita incorporated in BCM against bacterial strains commonly present in wound and burns. The agar-dilution susceptibility testing was used to determine the minimum inhibitory concentration (MIC) for S. aureus, E. coli, and P. aeruginosa. The standardized extracts of A. vera, M. recutita, and C. offi cinalis were, respectively, used at 3.25% of total polysaccharides, 1% of apigenin 7-O-glucoside and 0.084% of total fl avonoids expressed in quercetin. The BCM incorporated with A. vera extract was effi cient to prevent the growth of P. aeruginosa and S. aureus. BCM loaded with C. offi cinalis inhibited the growth of S. aureus. The BCM loaded with A. vera and C. offi cinalis extract showed better antibacterial activities against P. aeruginosa and S. aureus and, consequently, properties to prevent infectious disease in the wound or burn caused by these bacteria.

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Burns and long-term infectious disease morbidity: A population-based study

Cited by 36 publications

References 41 publications

A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

Yanıklarda Akut Dönem ve Hemşirelik Bakımı

Medicinal plant extract associated with bacterial cellulose membrane: Antibacterial activity and physicochemical properties

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