Functionally graded composite (FGC) materials are categorized as advanced materials that display different thermal and mechanical responses compared with well-known composites, such as carbon fiber or glass fiber-reinforced composites. This paper presents the experimental results for the drilling of three materials, namely glass/epoxy, carbon/epoxy, and FGC material. FGC was compared with carbon and glass/epoxy composites in terms of thrust force, delamination factor, diameter of hole, and roundness during drilling. This study illustrated that the drilling performance of FGC is considerably more complicated than that of more common composite materials, such as glass/epoxy and carbon/epoxy. Delamination factor at the exit of hole during drilling of FGC was mainly affected by the material placed at the exit of the hole. The proposed cutting parameters and drill geometries to minimize the occurrence of delamination during drilling of carbon/epoxy and glass/epoxy apparently does not meet the expectation in drilling FGC.