Bursa of Fabricius

Mustonen, Laura; Alinikula, Jukka; Lassila, O.; Nera, Kalle‐Pekka

doi:10.1002/9780470015902.a0000506.pub3

Cited by 4 publications

(5 citation statements)

References 33 publications

(29 reference statements)

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“…These results indicated that there were differences in cell proliferation and apoptosis. Previous research had demonstrated that only approximately 5% of daily B-cell production survives to form a mature postbursal B-cell population, which supports the observation that there were frequent B cell apoptosis and proliferation in the brusa [4]. Therefore, we inferred that cell cycle, apoptosis and proliferation were different between two duck breeds, which can influence the quantities of mature functional B cells.…”

Section: Discussionsupporting

confidence: 84%

“…The GO terms, such as cellular response to stimulus, cellular communication, receptor activity, enriched the most target genes. The bursa of Fabricius, with many B cells, is one of essential immune organs [ 4 ]. The mature B cells can synthesis immunoglobulin and it had affirmed that there are IgM, IgG, and IgA in avian, which had a role in immune response to fight infection, cytotoxicity, cytolysis and neutralize virus infection [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In 1621, the bursa was originally described by Hieronymus Fabricius [ 3 ]. Subsequent researches have shown that BF is involved in the occupation, proliferation, differentiation and maturity of B lymphocytes which are one of the most significant immune cells that can produce immunoglobulin (Ig) when the body is stimulated by antigens [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Enrichment and verification of differentially expressed miRNAs in bursa of Fabricius in two breeds of duck

Luo

Liu

et al. 2016

Asian-Australas J Anim Sci

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ObjectiveThe bursa of Fabricius (BF) is a central humoral immune organ belonging specifically to avians. Recent studies had suggested that miRNAs were active regulators involved in the immune processes. This study was to investigate the possible differences of the BF at miRNA level between two genetically disparate duck breeds.MethodsUsing Illumina next-generation sequencing, the miRNAs libraries of ducks were established.ResultsThe results showed that there were 66 differentially expressed miRNAs and 28 novel miRNAs in bursa. A set of abundant miRNAs (i.e., let-7, miR-146a-5p, miR-21-5p, miR-17~92) which are involved in immunity and disease were detected and the predicted target genes of the novel miRNAs were associated with duck high anti-adversity ability. By gene ontology analysis and enriching KEGG pathway, the targets of differential expressed miRNAs were mainly involved in immunity and disease, supporting that there were differences in the BF immune functions between the two duck breeds. In addition, the metabolic pathway had the maximum enriched target genes and some enriched pathways that were related to cell cycle, protein synthesis, cell proliferation and apoptosis. It indicted that the difference of metabolism may be one of the reasons leading the immune difference between the BF of two duck breeds.ConclusionThis data lists the main differences in the BF at miRNAs level between two genetically disparate duck breeds and lays a foundation to carry out molecular assisted breeding of poultry in the future.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enrichment and verification of differentially expressed miRNAs in bursa of Fabricius in two breeds of duck

Luo

Liu

et al. 2016

Asian-Australas J Anim Sci

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“…Development of the antibodyproducing B-lymphocyte lineage in birds mostly takes place in bursa (Mustonen et al 2010). Our data clearly demonstrate that N. sativa seed is able to induce changes in histomorphometric parameters of bursa of Fabricius where bursal follicles of birds treated with N. Sativa especially at the highest dose were larger and more frequent as compared to control group.…”

Section: Resultssupporting

confidence: 53%

Effect of Dietary Inclusion of Black Cumin (Nigella sativa) Seeds on Histological Parameters of Caecal Tonsils and Bursa of Fabricius in Broiler Chickens

Hamedi

Shomali

Molayemvand

2015

Egyptian Academic Journal of Biological Sciences, D. Histology

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Histology& Histochemistry Journal include various morphological, anatomical, histological, histochemical, toxicological , physiological changes associated with individuals, and populations. In addition, the journal promotes research on biochemical and molecularbiological or environmental, toxicological and occupational aspects of pathology are requested as well as developmental and histological studies on light and electron microscopical level, or case reports.. www.eajbs.eg.net Provided for non-commercial research and education use. Not for reproduction, distribution or commercial use.

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“…Until sexual maturity at 4-6 months, it is the place of B cell differentiation. Subsequently, the bursa regresses completely and the B cells migrate to secondary lymphatic organs and the blood, from then on representing the peripheral B cell pool (Mustonen et al 2001).…”

Section: Introductionmentioning

confidence: 99%

No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes

Erath

Groettrup

2014

Immunogenetics

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The proteasome is the main protein-degrading machine within the cell, producing ligands for MHC class I molecules. It is a cylindrical multicatalytic protease complex, and the catalytic activity is mediated by the three subunits β1, β2, and β5 which possess caspase-, trypsin-, and chymotrypsin-like activities, respectively. By stimulation with interferon (IFN)-γ the replacement of these subunits by β1i, β2i, and β5i is induced leading to formation of immunoproteasomes with altered proteolytic and antigen processing properties. The genes coding for these immunosubunits are restricted to jawed vertebrates but have so far not been found in the genomes of birds, e.g., chicken, turkey, quail, black grouse and zebra finch. However, the chicken genome sequences are not completely assigned; therefore, we investigated the presence of immunoproteasome on protein level. 20S proteasome was purified from the chicken brain, blood, spleen, and bursa of Fabricius, followed by separation via two-dimensional (2D) gel electrophoresis. We analyzed the protein spots derived from the spleen and brain by mass spectrometry and could identify all 14 proteasomal subunits, but there were no differences detectable in the spot patterns. Moreover, we stimulated the chicken spleen cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin aiming at the induction of immunoproteasome, but in spite of the induction of proliferation and IFN-γ, no evidence for immunoproteasome formation in chicken could be obtained. This result was substantiated by the finding that 20S proteasomes isolated from immune and non-immune tissues showed very similar peptidolytic activities. Taken together, our results indicate that chicken lack immunoproteasomes also on protein level.

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Bursa of Fabricius

Cited by 4 publications

References 33 publications

Enrichment and verification of differentially expressed miRNAs in bursa of Fabricius in two breeds of duck

Enrichment and verification of differentially expressed miRNAs in bursa of Fabricius in two breeds of duck

Effect of Dietary Inclusion of Black Cumin (Nigella sativa) Seeds on Histological Parameters of Caecal Tonsils and Bursa of Fabricius in Broiler Chickens

No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes

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