Burst-Induced Anti-Hebbian Depression Acts through Short-Term Synaptic Dynamics to Cancel Redundant Sensory Signals

Harvey‐Girard, Erik; Lewis, John E.; Maler, Leonard

doi:10.1523/jneurosci.0303-10.2010

Cited by 58 publications

(75 citation statements)

References 102 publications

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“…burst windows were ϽϮ10 ms (Harvey-Girard et al, 2010). We found that the small bursts were sufficient to produce excellent cancellation for high-frequency inputs, but the plasticity window was too narrow to cancel low-frequency inputs.…”

Section: Discussionmentioning

confidence: 73%

“…2C,D). These bursts are important for both stimulus encoding (Gabbiani et al, 1996;Oswald et al, 2004;Marsat et al, 2009) and induction of LTD at the synapse between PF and pyramidal cells (Harvey-Girard et al, 2010). Note that in the latter case, small and large bursts result in different associative time windows for LTD (see below).…”

Section: Resultsmentioning

confidence: 98%

“…During global stimulation, burst-induced depression decreases the synaptic weight of each segment according to a quadratic fit of the plasticity rule recently identified in vitro (Harvey-Girard et al, 2010). The strength of the burst-induced depression rules, 2 and 4 , are kept constant across frequencies in the initial version of our model (see Fig.…”

Section: Methodsmentioning

confidence: 99%

“…We must therefore assume the existence of a mechanism counteracting this depression. Since an activity-dependent potentiation could not be identified in vitro (Harvey-Girard et al, 2010), a simple activity-and frequencyindependent potentiating rule was added where all weights slowly relax back to w max with a time constant of w :…”

Section: Methodsmentioning

confidence: 99%

“…PF-SP cell synapses are subject to correlative LTD, in which depression occurs when both presynaptic and postsynaptic burst firing occur within a certain time window (Harvey-Girard et al, 2010). We used this in vitro plasticity rule, together with the estimated distribution of conduction delays in the feedback pathway, to construct a minimal model of the cancellation mechanism.…”

Section: Introductionmentioning

confidence: 99%

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Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Bol¹,

Marsat²,

Harvey‐Girard³

et al. 2011

Journal of Neuroscience

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For optimal sensory processing, neural circuits must extract novel, unpredictable signals from the redundant sensory input in which they are embedded, but the detailed cellular and network mechanisms that implement such selective cancellation are presently unknown. Using a combination of modeling and experiment, we characterize in detail a cerebellar circuit in weakly electric fish, showing how it can carry out this computation. We use a model incorporating the wide range of experimentally estimated parallel fiber feedback delays and a burst-induced LTD rulederivedfrominvitroexperimentstoexplaintheprecisecancellationofredundantsignalsobservedinvivo.Ourmodeldemonstrateshowthe backpropagation-dependent burst dynamics adjusts the temporal pairing width of the plasticity mechanism to precisely match the frequency of the redundant signal. The model also makes the prediction that this cerebellar feedback pathway must be composed of frequency-tuned channels; this prediction is subsequently verified in vivo, highlighting a novel and general capability of cerebellar circuitry.

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Section: Discussionmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Bol¹,

Marsat²,

Harvey‐Girard³

et al. 2011

Journal of Neuroscience

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Organization of the gymnotiform fish pallium in relation to learning and memory: I. Cytoarchitectonics and cellular morphology

Giassi

Harvey‐Girard

Valsamis

et al. 2012

J of Comparative Neurology

143

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The present article examines the anatomical organization of the dorsal telencephalon of two gymnotiform fish: Gymnotus sp. and Apteronotus leptorhynchus. These electric fish use elaborate electrical displays for agonistic and sexual communication. Our study emphasizes mainly pallial divisions: dorsolateral (DL), dorsodorsal (DD), and dorsocentral (DC), previously implicated in social learning dependent on electric signals. We found that the pallial cytoarchitectonics of gymnotiformes are similar to those reported for the commonly studied goldfish, except that DC is larger and better differentiated in gymnotiformes. We identified a new telencephalic region (Dx), located between DL and DC, and describe the morphological and some biochemical properties of its neurons. Most neurons in DL, DD, and DC are glutamatergic with spiny dendrites. However, the size of these cells as well as the orientation and extent of their dendrites vary systematically across these regions. In addition, both DD and DL contained numerous small GABAergic interneurons as well as well-developed GABAergic plexuses. One important and novel observation is that the dendrites of the spiny neurons within all three regions remain confined to their respective territories. We confirm that DL and DC express very high levels of NMDA receptor subunits as well as CaMKIIα, a key downstream effector of this receptor. In contrast, this enzyme is nearly absent in DD, while NMDA receptors are robustly expressed, suggesting different rules for synaptic plasticity across these regions. Remarkably, GABAergic pallial neurons do not express CaMKIIα, in agreement with previously reported results in the cortex of rats.

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Expression of the cannabinoid CB1 receptor in the gymnotiform fish brain and its implications for the organization of the teleost pallium

Harvey‐Girard

Giassi

Ellis

et al. 2013

J of Comparative Neurology

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Cannabinoid CB1 receptors (CB1R) are widely distributed in the brains of many vertebrates, but whether their functions are conserved is unknown. The weakly electric fish, Apteronotus leptorhynchus (Apt), has been well studied for its brain structure, behavior, sensory processing, and learning and memory. It therefore offers an attractive model for comparative studies of CB1R functions. We sequenced partial AptCB1R mRNAs and performed in situ hybridization to localize its expression. Partial AptCB1R protein sequence was highly conserved to zebrafish (90.7%) and mouse (81.9%) orthologs. AptCB1R mRNA was highly expressed in the telencephalon. Subpallial neurons (dorsal, central, intermediate regions and part of the ventral region, Vd/Vc/Vi, and Vv) expressed high levels of AptCB1R transcript. The central region of dorsocentral telencephalon (DC(core) ) strongly expressed CB1R mRNA; cells in DC(core) project to midbrain regions involved in electrosensory/visual function. The lateral and rostral regions of DC surrounding DC(core) (DC(shell) ) lack AptCB1R mRNA. The rostral division of the dorsomedial telencephalon (DM1) highly expresses AptCB1R mRNA. In dorsolateral division (DL) AptCB1R mRNA was expressed in a gradient that declined in a rostrocaudal manner. In diencephalon, AptCB1R RNA probe weakly stained the central-posterior (CP) and prepacemaker (PPn) nuclei. In mesencephalon, AptCB1R mRNA is expressed in deep layers of the dorsal (electrosensory) torus semicircularis (TSd). In hindbrain, AptCB1R RNA probe weakly labeled inhibitory interneurons in the electrosensory lateral line lobe (ELL). Unlike mammals, only few cerebellar granule cells expressed AptCB1R transcripts and these were located in the center of eminentia granularis pars posterior (EGp), a cerebellar region involved in feedback to ELL.

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Burst-Induced Anti-Hebbian Depression Acts through Short-Term Synaptic Dynamics to Cancel Redundant Sensory Signals

Cited by 58 publications

References 102 publications

Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Organization of the gymnotiform fish pallium in relation to learning and memory: I. Cytoarchitectonics and cellular morphology

Expression of the cannabinoid CB1 receptor in the gymnotiform fish brain and its implications for the organization of the teleost pallium

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