Burst Spinal Cord Stimulation: Review of Preclinical Studies and Comments on Clinical Outcomes

Chakravarthy, Krishnan; Kent, Alexander R.; Raza, Adil; Fang, Xing; Kinfe, Thomas M.

doi:10.1111/ner.12756

Cited by 42 publications

(47 citation statements)

References 68 publications

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“…In line with previous tonic SCS and DRG‐SCS human studies (uncontrolled), serum levels of pro‐inflammatory mediators such as IL‐1β, TNF‐α, and IL‐6 were significantly increased compared to healthy individuals within the entire study period. For instance, an elevated CSF level of BDNF was demonstrated in FBSS patients with predominant neuropathic leg pain under tonic SCS compared to healthy controls . BDNF, another inflammatory marker of neuropathic pain and depression, was higher in our chronic neuropathic pain cohort, but remained unchanged after L4‐DRG STIM .…”

Section: Discussionmentioning

confidence: 63%

See 1 more Smart Citation

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns

Gravius

Chaudhry

Muhammad

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 63%

“…Extracellular HMGB‐1 exposition activates macrophages/monocytes host response in the early phase of inflammation. To the best of our knowledge, this is the first study demonstrating increased serum levels of HMGB‐1 in CRPS patients treated with L4‐DRG stimulation .…”

Section: Discussionmentioning

confidence: 75%

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns

Gravius

Chaudhry

Muhammad

et al. 2019

Neuromodulation: Technology at the Neural Interface

Self Cite

View full text Add to dashboard Cite

“…However, the cause and mechanism of the experimental results remain unclear. This makes physiological sense, given that most neurons in the central nervous system fire bursts of action potentials, interspersed with periods of rest [34]. We believe that burst stimulation was more effective at modulating behavior, potentially due to its closer relationship to endogenous nervous system firing patterns, though additional studies are needed to clarify this finding more directly.…”

Section: Discussionmentioning

confidence: 99%

Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats

Kong

Shin

Koh

et al. 2019

Stereotact Funct Neurosurg

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Background: The medial forebrain bundle (MFB) is involved in the integration of pleasure and reward. Previous studies have used various stimulation parameters for operant conditioning, though the effectiveness of these parameters has not been systematically studied. Objectives: The purpose of the present study was to investigate the optimal MFB stimulation parameters for controlling the conditioned behavior of rats. Methods: We evaluated four factors, including intensity, frequency, pulse duration, and train duration, to determine the effect of each on lever pressure applied by animals. We further compared burst and tonic stimulation in terms of learning and performance abilities. Results: The number of lever presses increased with each factor. Animals in the burst stimulation group exhibited more lever presses. Furthermore, the average speed in the 田 maze among burst stimulation group subjects was higher. Conclusion: We determined the optimal parameters for movement control of animals in operant conditioning and locomotor tasks by adjusting various electrical stimulation parameters. Our results reveal that a burst stimulation is more effective than a tonic stimulation for increasing the moving speed and number of lever presses. The use of this stimulation technique also allowed us to minimize the training required to control animal behavior.

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“…Classically, it is thought to activate the large rapidly conducting Aβ fibres; leading to the potentiation of inhibitory neurons on pain, as per Wall and Melzack’s theory [32]. The efficacy of alternative stimulation waveforms such as high frequency and burst, however, suggest that a revision of this theory is needed [33]. For conventional SCS, electrodes are placed with the stimulating tips between the C5 and T1 vertebral bodies for upper limb pain, and between T9 and T11 for lower extremity pain.…”

Section: Management Of Chronic Painmentioning

confidence: 99%

The Current State of Deep Brain Stimulation for Chronic Pain and Its Context in Other Forms of Neuromodulation

2018

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Chronic intractable pain is debilitating for those touched, affecting 5% of the population. Deep brain stimulation (DBS) has fallen out of favour as the centrally implantable neurostimulation of choice for chronic pain since the 1970–1980s, with some neurosurgeons favouring motor cortex stimulation as the ‘last chance saloon’. This article reviews the available data and professional opinion of the current state of DBS as a treatment for chronic pain, placing it in the context of other neuromodulation therapies. We suggest DBS, with its newer target, namely anterior cingulate cortex (ACC), should not be blacklisted on the basis of a lack of good quality study data, which often fails to capture the merits of the treatment.

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Burst Spinal Cord Stimulation: Review of Preclinical Studies and Comments on Clinical Outcomes

Cited by 42 publications

References 68 publications

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns

Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats

The Current State of Deep Brain Stimulation for Chronic Pain and Its Context in Other Forms of Neuromodulation

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