Bursts and hyperexcitability in non-myelinated axons of the rat hippocampus

Palani, D.; Baginskas, Armuntas; Raastad, Morten

doi:10.1016/j.neuroscience.2010.03.021

Cited by 20 publications

(33 citation statements)

References 39 publications

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“…Conversely, previous studies were able to evaluate conduction properties from the recorded activity of a single axon, with a glass pipettes and high-density MEA [19,24]. Conduction velocity recorded in the present study was 0.318-0.381 m/s, compared to the velocity of 0.36 m/s in the previous study [25].…”

Section: Discussioncontrasting

confidence: 80%

Experimental evaluation of activity-dependent changes in axonal conduction delay using a microtunnel device

Shimba

Sakai

Kotani

et al. 2016

NOLTA

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Axons are computational units in neuronal networks. Little is known about relationships between firing frequency and the extent of changes in axonal conduction velocity. Therefore, we stimulated axons extending through microtunnels with various stimulation frequencies, and recorded axonal conduction delays. Additionally, ZD7288, an h-current blocker, was added during stimulation to elucidate the mechanism underlying the change. Changes observed in the first 75 stimuli with a frequency of 20 Hz were smaller than those observed with lower frequencies, a tendency that was abolished by ZD7288. These results suggest that our method is capable of detecting activity-dependent changes in axonal conduction property.

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Section: Discussioncontrasting

confidence: 80%

Experimental evaluation of activity-dependent changes in axonal conduction delay using a microtunnel device

Shimba

Sakai

Kotani

et al. 2016

NOLTA

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“…Certainly, recurrent terminals express various types of K channel which control transmitter release by limiting terminal depolarization. They may include the delayed rectifier type channels Kv1.1 and Kv1.2, the fast-inactivating A-type channel Kv1.4 (Debanne et al, 1997; Kopysova and Debanne, 1998; Lorincz and Nusser, 2008; Palani et al, 2010) as well as K-channels sensitive to both Ca and voltage (Saviane et al, 2003; Raffaelli et al, 2004) and the muscarine sensitive M-channel Kv7/KCNQ (Vervaeke et al, 2006). …”

Section: Ca3 Pyramidal Cell Terminals: Numbers Form Contents Channmentioning

confidence: 99%

Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network

Duigou

Simonnet

Teleńczuk

et al. 2014

Front. Cell. Neurosci.

102

108

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In the CA3 region of the hippocampus, pyramidal cells excite other pyramidal cells and interneurons. The axons of CA3 pyramidal cells spread throughout most of the region to form an associative network. These connections were first drawn by Cajal and Lorente de No. Their physiological properties were explored to understand epileptiform discharges generated in the region. Synapses between pairs of pyramidal cells involve one or few release sites and are weaker than connections made by mossy fibers on CA3 pyramidal cells. Synapses with interneurons are rather effective, as needed to control unchecked excitation. We examine contributions of recurrent synapses to epileptiform synchrony, to the genesis of sharp waves in the CA3 region and to population oscillations at theta and gamma frequencies. Recurrent connections in CA3, as other associative cortices, have a lower connectivity spread over a larger area than in primary sensory cortices. This sparse, but wide-ranging connectivity serves the functions of an associative network, including acquisition of neuronal representations as activity in groups of CA3 cells and completion involving the recall from partial cues of these ensemble firing patterns.

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“…Kv1.3 channels have been identified in parallel fiber axons of cerebellar granule cells (305,543). The excitability of Schaffer collaterals is strongly enhanced by ␣-dendrotoxin (DTX; a blocker of Kv1.1, Kv1.2, and Kv1.6) or margatoxin (MgTx; a blocker of Kv1.2 and Kv1.3), indicating that Kv1.2 is an important channel subunit for controlling excitability in these fibers (395 ϩ current activated in a mossy fiber bouton outside-out patch by pulses from Ϫ70 to ϩ30 mV in the absence (control) and in the presence of 1 M ␣-dendrotoxin (␣-DTX). Bottom right: comparison of the spike waveform in the soma and mossy fiber terminal (MF terminal) of a hippocampal granule cell.…”

Section: Channels In Unmyelinated Axonsmentioning

confidence: 99%

Axon Physiology

Debanne

Campanac

Bialowas

et al. 2011

Physiological Reviews

557

492

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Axons are generally considered as reliable transmission cables in which stable propagation occurs once an action potential is generated. Axon dysfunction occupies a central position in many inherited and acquired neurological disorders that affect both peripheral and central neurons. Recent findings suggest that the functional and computational repertoire of the axon is much richer than traditionally thought. Beyond classical axonal propagation, intrinsic voltage-gated ionic currents together with the geometrical properties of the axon determine several complex operations that not only control signal processing in brain circuits but also neuronal timing and synaptic efficacy. Recent evidence for the implication of these forms of axonal computation in the short-term dynamics of neuronal communication is discussed. Finally, we review how neuronal activity regulates both axon morphology and axonal function on a long-term time scale during development and adulthood.

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Bursts and hyperexcitability in non-myelinated axons of the rat hippocampus

Cited by 20 publications

References 39 publications

Experimental evaluation of activity-dependent changes in axonal conduction delay using a microtunnel device

Experimental evaluation of activity-dependent changes in axonal conduction delay using a microtunnel device

Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network

Axon Physiology

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